Results 121 to 130 of about 63,116 (292)
Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj +25 more
wiley +1 more source
Subversive humour in educational contexts in India, Malaysia and Vietnam
, 2016 This paper aims to explore the use of subversive humour in a range of educational contexts in India, Malaysia and Vietnam, including a local secondary school in India, a department in a university in Malaysia, and a public language learning centre in ...
Maheshwari, Disha +3 more
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Advanced Science, EarlyView.A portable, sensorized, and controlled dexterous thumb‐enhanced glove helps stroke survivors swipe phones, twist caps, and perform other tasks. It is based on a powerful continuously, segmented origami dual chamber actuator to achieve active thumb CMC and MCP joint assistance and passively extend the IP joint.
Disheng Xie +10 more
wiley +1 more source
Advanced Science, EarlyView.A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo +18 more
wiley +1 more source
Humour in the novel 1800-1850 : the moral vision and the autonomous imagination [PDF]
This thesis attempts to trace the development of two kinds of humorous sensibility in the fiction of the period 1800-1850, and to analyse the tensions between them.
Fairclough, Peter
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Advanced Science, EarlyView.Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song +5 more
wiley +1 more source
Humour and Learning: A Self-Study of My Practice as an Adult Educator [PDF]
, 2013 This study examined my lived experiences as a frontline practitioner and adult educator in a local nonprofit community organization. Using self-study research methodology, I explored my professional practice as a facilitator of job search skills training
Samuels, Joanna
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Advanced Science, EarlyView.Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu +11 more
wiley +1 more source
Η σχέση του “Καραγκιόζη” με το νεοελληνικό γέλιο [PDF]
, 2015 Κατά καιρούς, έχει αμφισβητηθεί η άποψη ότι ο Καραγκιόζης και οι ήρωες του νεοελληνικού Θεάτρου Σκιών ανήκουν στους λεγόμενους «πατέρες» της νεοελληνικής σάτιρας.
Agrafiotis, Thomas
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