Results 111 to 120 of about 162,965 (256)
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials
British Journal of Pharmacology, EarlyView.Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen +2 more
wiley +1 more source
Homo sapiens, industrialisation and the environmental mismatch hypothesis
Biological Reviews, EarlyView.ABSTRACT For the vast majority of the evolutionary history of Homo sapiens, a range of natural environments defined the parameters within which selection shaped human biology. Although human‐induced alterations to the terrestrial biosphere have been evident for over 10,000 years, the pace and scale of change has accelerated dramatically since the onset
Daniel P. Longman, Colin N. Shaw
wiley +1 more source
Top Managerial Network Relations for Knowledge Transfer: Exploring Gender Differences
Creativity and Innovation Management, EarlyView.ABSTRACT In the ongoing debate surrounding the gender gap in top managerial positions, various possible causes have been explored, with different networking patterns being one of them. However, we still lack detailed insights on how knowledge transfer via networks varies based on gender.
Sonja Sperber, Christian Linder
wiley +1 more source
Diagnosis and Management of Mucopolysaccharidosis Type II (Hunter Syndrome) in Poland. [PDF]
Biomedicines, 2023 Żuber Z +4 more
europepmc +1 more source
Patients With Pituitary Neuroendocrine Tumours Requiring Neurosurgery –Who Is Referring Them?
Clinical Endocrinology, EarlyView.ABSTRACT Objective Patients living with pituitary neuroendocrine tumours (PitNETs) present with a spectrum of clinical manifestations and often follow a circuitous route to diagnosis, resulting in diagnostic delays. The objective of this study is to identify and report the various sources of referrals for patients who underwent pituitary resection for ...
Doua S. Ahmed +11 more
wiley +1 more source
Conservation Biology, EarlyView.Abstract Wildlife reintroductions are socioecological processes entailing the intentional movement of organisms by people. In animal reintroductions, there is growing recognition of the importance of human dimensions and efforts to integrate these into reintroduction projects. To conceptually reframe reintroductions as processes of renewed coexistence (
Roger Edward Auster +3 more
wiley +1 more source
Double Valve Replacement in a Patient With Hunter Syndrome. [PDF]
Cureus, 2022 Keshavamurthy S +6 more
europepmc +1 more source
Ecological Entomology, EarlyView.We experimentally manipulated top‐down (predator exclusion) and bottom‐up (fertilisation) forces in a temperate forest understory to test effects on arthropod densities, body sizes and herbivory. Predator exclusion had no detectable effect on arthropod density, herbivory damage or body size, whereas fertilisation increased herbivory damage and ...
Jan Kollross +3 more
wiley +1 more source
Airway Findings in Patients with Hunter Syndrome Treated with Intravenous Idursulfase. [PDF]
J Clin Med, 2023 De Vuyst R +5 more
europepmc +1 more source