Results 31 to 40 of about 84,353 (267)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Internet Archaeology, 2002 The City of York Council has been pursuing a strict policy of in situ preservation of archaeological deposits since April 1990. Planning consent is normally granted in the historic core of York for a new development so long as less than 5% of the ...
M. Davis +3 more
doaj +1 more source
Science, 2014 In a world that is increasingly connected, that grows smaller every day, and where so many human actions are exposed to prying eyes, it seems almost incomprehensible that the world's largest twinjet aircraft, with 239 passengers and crew, could vanish for more than 2 months.
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Microorganisms, 2020 Recently, we unveiled taxonomical and functional differences in Egyptian mongoose (Herpestes ichneumon) gut microbiota across sex and age classes by microbial profiling.
André C. Pereira +3 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
ESTIMATION OF IMMUNE-HEMATOLOGICAL PARAMETERS OF FUR-BEARING ANIMALS IN TOXOCARIASIS
Российский паразитологический журнал, 2016 Objective of research: To study the prevalence of toxocariasis in the Kirov region, the coproovoscopic investigations of domestic carnivorous and caged fur-bearing animals have been conducted.Materials and methods: Before and after dehelmintization ...
L. A. Napisanova +5 more
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Conservation Science and Practice, 2020 Indigenous people manage or have tenure rights on over a quarter of the world's land surface. While there is growing interest in “evidence‐based” natural resource management, there are few documented experiences with “evidence‐based” practice in ...
Christine Cuyler +7 more
doaj +1 more source