Results 71 to 80 of about 84,353 (267)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Preliminary assessment of illegal hunting by communities adjacent to the northern Gonarezhou National Park, Zimbabwe

open access: yes, 2011
Illegal hunting of wildlife is a major issue in today’s society, particularly in tropical ecosystems. In this study, a total of 114 local residents from eight villages located in four wards adjacent to the northern Gonarezhou National Park, south-eastern
Gandiwa, E.
core  

PUBLIC ADMINISTRATION IN THE FIELD OF TRADE IN HUNTING AND FISHING PRODUCTS IN GALICIA, THE 19TH AND EARLY 20TH CENTURIES: THE VETERINARY ASPECT

open access: yesПублічне управління та регіональний розвиток, 2018
The veterinary aspects of public administration in the trade of hunting and fishing products in Galicia of the 19th and the beginning of the 20th centuries are considered.
Ihor Drobot, Oleg Protsiv
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Polygamy in the Marsh Harrier, Circus aeruginosus: Individual Variation in Hunting Performance and Number of Mates [PDF]

open access: yes, 1982
1. Theories postulating that sexual task differentiation may lead to polygamy such that the sex investing the least effort in raising the offspring, engages in simultaneous matings, contrast with polygyny in raptors where the male provides most of the ...
Altenburg, Wibe,   +7 more
core   +1 more source

The Hunt for Cyclin [PDF]

open access: yesCell, 2008
It is 25 years since Tim Hunt discovered cyclin, the oscillating protein that drives activation of cyclin-dependent kinases and entry into mitosis (Evans et al., 1983).
openaire   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Demand for Wildlife Hunting in British Columbia [PDF]

open access: yes
We present estimates of the demand for hunting licenses by residents and non residents in British Columbia for the period 1971–2000. We obtain estimates of both short-run and long-run price elasticities and discuss their revenue implications for future ...
G. Cornelis van Kooten   +2 more
core  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy