Results 271 to 280 of about 44,176 (282)

A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila

Nature Genetics, 2002
Joan S Steffan, Leslie M Thompson
exaly  

Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress

Nature Communications, 2013
F Ulrich Hartl, Gerardo Z Lederkremer
exaly  

Trehalose, a Novel mTOR-independent Autophagy Enhancer, Accelerates the Clearance of Mutant Huntingtin and α-Synuclein

Journal of Biological Chemistry, 2007
Sovan Sarkar, Zebo Huang, Alan Tunnacliffe   +2 more
exaly  

Discovery of Small Molecules that Induce the Degradation of Huntingtin

Angewandte Chemie - International Edition, 2017
Shusuke Tomoshige, Kenji Ohgane, Minoru Ishikawa   +2 more
exaly  

The Aggregation-Enhancing Huntingtin N-Terminus Is Helical in Amyloid Fibrils

Journal of the American Chemical Society, 2011
Cody L Hoop, Ronald Wetzel, Patrick C A Van Der Wel   +2 more
exaly  

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

Nature Medicine, 2011
Wenjun Song, Jin Chen, Géraldine Liot
exaly  

Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease

Science Translational Medicine, 2018
Amber L Southwell, Douglas R Langbehn, Niels Skotte   +2 more
exaly  

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

Cell Death and Differentiation, 2008
exaly  

Cell-type-specific CAG repeat expansions and toxicity of mutant Huntingtin in human striatum and cerebellum

Nature Genetics
Jean-Yves Masson, Christopher E Pearson, Nathaniel Heintz   +2 more
exaly  

Huntingtin transports BDNF

The Lancet Neurology, 2004
openaire   +1 more source