Results 1 to 10 of about 57,910 (287)

Neural and biomarker correlates of the Parkinson's Disease–Cognitive Rating Scale in Huntington's disease [PDF]

NeuroImage: Reports
Background: Cognitive decline is a core feature of Huntington's disease (HD), often preceding motor symptoms and progressing with disease severity. While several neuropsychological tests track cognitive changes, few studies have examined the biological ...
Saul Martinez-Horta, Arnau Puig-Davi, Frederic Sampedro, Jesús Pérez-Pérez, Carla Franch-Martí, Gonzalo Olmedo-Saura, Elisa Rivas-Asensio, Anna Vazquez-Oliver, Laura Pérez-Carasol, Andrea Horta-Barba, Javier Pagonabarraga, Jaime Kulisevsky   +11 more
doaj   +2 more sources

Huntington disease [PDF]

Nature Reviews Disease Primers, 2015
Huntington disease is devastating to patients and their families - with autosomal dominant inheritance, onset typically in the prime of adult life, progressive course, and a combination of motor, cognitive and behavioural features. The disease is caused by an expanded CAG trinucleotide repeat (of variable length) in HTT, the gene that encodes the ...
Bates, Gillian P., Dorsey, Ray, Gusella, James F., Hayden, Michael R., Kay, Chris, Leavitt, Blair R., Nance, Martha, Ross, Christopher A., Scahill, Rachael I., Wetzel, Ronald, Wild, Edward J., Tabrizi, Sarah J.   +11 more
  +7 more sources

Altered iron and myelin in premanifest Huntington's Disease more than 20 years before clinical onset: Evidence from the cross-sectional HD Young Adult Study

EBioMedicine, 2021
Background: Pathological processes in Huntington's disease (HD) begin many years prior to symptom onset. Recently we demonstrated that in a premanifest cohort approximately 24 years from predicted disease onset, despite intact function, there was ...
Eileanoir B. Johnson, Christopher S. Parker, Rachael I. Scahill, Sarah Gregory, Marina Papoutsi, Paul Zeun, Katherine Osborne-Crowley, Jessica Lowe, Akshay Nair, Carlos Estevez-Fraga, Kate Fayer, Geraint Rees, Hui Zhang, Sarah J. Tabrizi   +13 more
doaj   +1 more source

Progressive alterations in white matter microstructure across the timecourse of Huntington's disease

Brain and Behavior, 2023
Background Whole‐brain longitudinal diffusion studies are crucial to examine changes in structural connectivity in neurodegeneration. Here, we investigated the longitudinal alterations in white matter (WM) microstructure across the timecourse of ...
Carlos Estevez‐Fraga, Michael S. Elmalem, Marina Papoutsi, Alexandra Durr, Elin M. Rees, Nicola Z. Hobbs, Raymund A. C. Roos, Bernhard Landwehrmeyer, Blair R. Leavitt, Douglas R. Langbehn, Rachael I. Scahill, Geraint Rees, Sarah J. Tabrizi, Sarah Gregory   +13 more
doaj   +1 more source

Ex vivo 100 μm isotropic diffusion MRI‐based tractography of connectivity changes in the end‐stage R6/2 mouse model of Huntington's disease

Neuroprotection, 2023
Background Huntington's disease is a progressive neurodegenerative disorder. Brain atrophy, as measured by volumetric magnetic resonance imaging (MRI), is a downstream consequence of neurodegeneration, but microstructural changes within brain tissue are ...
Ashwinee Manivannan, Lesley M. Foley, T. Kevin Hitchens, Ivan Rattray, Gillian P. Bates, Michel Modo   +5 more
doaj   +1 more source

Huntington's Disease [PDF]

Nursing Standard, 2004
Huntington's disease is a complex degenerative disorder that affects the central nervous system. Although it is a rare condition, nurses are ideally placed to assess and manage patients with the disease, while also providing information and support to family members.
  +6 more sources

Campus Update: April 1993 v. 5, no. 3 [PDF]

, 1993
Monthly newsletter of the BU Medical ...
Boston University Medical Center
core   +19 more sources

Exploring genetic factors involved in huntington disease age of onset. E2F2 as a new potential modifier gene [PDF]

, 2015
Age of onset (AO) of Huntington disease (HD) is mainly determined by the length of the CAG repeat expansion (CAGexp) in exon 1 of the HTT gene. Additional genetic variation has been suggested to contribute to AO, although the mechanism by which it could ...
Aguirre, Ana, Alkorta Aranburu, Gorka, De Arcaya, Amaia Álvarez, Fernández García, José Manuel, Fullaondo, Asier, García Barcina, María, Iriondo, Mikel, Lezcano García, Elena, Losada Domingo, Josémaría, Nielsen, Jørgen E., Pérez Ramos, José María, Registry, investigators of the European Huntington's Disease Network, ROMANO, SILVIA, Roos, Raymund A. C., Ruiz Ojeda, Javier, Saft, Carsten, Valcárcel Ocete, Leire, Zubiaga, Ana M.   +17 more
core   +9 more sources

Case report: Cerebellar sparing in juvenile Huntington's disease

Frontiers in Neurology, 2023
Juvenile Huntington's disease is an early-onset variant of Huntington's disease, generally associated with large CAG repeats and distinct clinical symptoms. The role of the cerebellum in Huntington's disease has been reevaluated, based on the presence of
Bruno Lopes Santos-Lobato, Bruno Lopes Santos-Lobato, Jéssica Santos de Souza Rocha, Luciano Chaves Rocha   +3 more
doaj   +1 more source

Memantine administration prevented chorea movement in Huntington’s disease: a case report

Journal of Medical Case Reports, 2023
Background Huntington’s disease is an autosomal dominant inherited disorder characterized by personality changes (such as irritability and restlessness) and psychotic symptoms (such as hallucinations and delusions).
Kazumasa Saigoh, Makito Hirano, Yoshiyuki Mitsui, Itsuki Oda, Atsuko Ikegawa, Makoto Samukawa, Keisuke Yoshikawa, Yuko Yamagishi, Susumu Kusunoki, Yoshitaka Nagai   +9 more
doaj   +1 more source