Brain muscarinic cholinergic receptors in Huntington's disease [PDF]
, 1992 Muscarinic cholinergic receptors and choline acetyltransferase (ChAT) activity were studied in postmortem brain tissue from patients with Huntington's disease and matched control subjects.
Agid, Y. +4 more
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Cold Spring Harbor Perspectives in Biology, 2011 Huntington's disease (HD) is the most common inherited neurodegenerative disease and is characterized by uncontrolled excessive motor movements and cognitive and emotional deficits. The mutation responsible for HD leads to an abnormally long polyglutamine (polyQ) expansion in the huntingtin (Htt) protein, which confers one or more toxic functions to ...
openaire +4 more sources
A Triple Insider's Take on Arts Therapy, Arts-based Community Development, and Huntington's Disease
Voices, 2015 In this article, I reflect on my experiences as someone with Huntington's Disease who works professionally as a development ethnomusicologist, and who creates musical, video, and graphic arts for healing in communities I know.
Brian Schrag
doaj +1 more source
Metacognitive insight into cognitive performance in Huntington’s disease gene carriers
BMJ Neurology Open, 2022 Objectives Insight is an important predictor of quality of life in Huntington’s disease and other neurodegenerative conditions. However, estimating insight with traditional methods such as questionnaires is challenging and subjected to limitations.
Roger A Barker +3 more
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Bioinformatic analysis of a microRNA regulatory network in Huntington's disease [PDF]
Journal of Integrative Neuroscience, 2020 Huntington's disease is an autosomal dominant hereditary neurodegenerative disease characterized by progressive dystonia, chorea and cognitive or psychiatric disturbances.
Zhi-Min Wang, Xiao-Yu Dong, Shu-Yan Cong
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Letter to the editor: autoimmune pathogenic mechanisms in Huntington’s disease [PDF]
, 2018 Letter to the Editor: Autoimmune pathogenic mechanisms in Huntington's ...
DE VINCENTIIS, Marco +5 more
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Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's disease-associated phenotypes. [PDF]
, 2018 See Huang and Gitler (doi:10.1093/brain/awy112) for a scientific commentary on this article.Lowering the levels of disease-causing proteins is an attractive treatment strategy for neurodegenerative disorders, among which Huntington's disease is an ...
An, P +17 more
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Proteostasis in striatal cells and selective neurodegeneration in Huntington’s disease
Frontiers in Cellular Neuroscience, 2014 Selective neuronal loss is a hallmark of neurodegenerative diseases, including Huntington’s disease (HD). Although mutant huntingtin, the protein responsible for Huntington’s disease, is expressed ubiquitously, a subpopulation of neurons in the striatum ...
Julia eMargulis +4 more
doaj +1 more source
Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study [PDF]
, 2007 BACKGROUND : Animal data and postmortem studies suggest a role of oxidative stress in the Huntington's disease (HD), but in vivo human studies have been scarce.
Babić, Tomislav +5 more
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Nature Communications, 2023 The corticostriatal dysfunction underlying Huntington’s disease remains incompletely understood. Here, the authors find increased intratelencephalic connectivity resulting from deficient cholinergic transmission in a mouse model of Huntington’s disease.
Tristano Pancani +9 more
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