Results 11 to 20 of about 37,609 (272)

Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2010
BACKGROUND: Huntington's disease (HD) is a rare triplet repeat (CAG) disorder. Advanced, multi-centre, multi-national research frameworks are needed to study simultaneously multiple complementary aspects of HD. This includes the natural history of HD, its management and the collection of clinical information and biosamples for research. METHODS:
Orth M, Handley OJ, Schwenke C, Dunnett S, Wild EJ, Tabrizi SJ, Landwehrmeyer GB, Bachoud Lévi AC, Bentivoglio AR, Biunno I, Bonelli R, Burgunder JM, Dunnett SB, Ferreira JJ, Giuliano J, Handley OJ, Heiberg A, Illmann T, van Kammen D, Landwehrmeye GB, Levey J, Nielsen JE, Päivärinta M, Roos RA, Sebastián AR, Tabrizi SJ, Vandenberghe W, Verellen Dumoulin C, Zaremba J, Uhrova T, Wahlström J, Schwenke C, Orth M, Illmann T, Wallner M, Barth K, Guedes LC, Finisterra AM, Garde MB, Bos R, Burg S, Ecker D, Handley OJ, Held C, Koppers K, Laurà M, Descals AM, McLean T, Mestre T, Minster S, Monza D, Townhill J, Orth M, Padieu H, Paterski L, Peppa N, Koivisto SP, Rialland A, Røren N, Sasinková P, Cubillo PT, Tritsch C, van Walsem MR, Witjes Ané MN, Yudina E, Zielonka D, Zielonka E, Zinzi P, Bonelli RM, Herranhof B, Holl A, Kapfhammer HP, Koppitz M, Magnet M, Otti D, Painold A, Reisinger K, Scheibl M, Hecht K, Lilek S, Müller N, Schöggl H, Ullah J, Brugger F, Hepperger C, Hotter A, Mahlknecht P, Nocker M, Seppi K, Wenning G, Buratti L, Hametner EM, Holas C, Hussl A, Mair K, Poewe W, Wolf E, Zangerl A, Braunwarth EM, Lilek S, Sinadinosa D, Walleczek AM, Bonelli RM, Ladurner G, Staffen W, Ribaï P, Verellen Dumoulin C, Flamez A, Morez V, de Raedt S, Boogaerts A, Vandenberghe W, van Reijen D, Klempíř J, Kucharík M, Roth J, Šenkárová Z, Hasholt L, Hjermind LE, Jakobsen O, Nørremølle A, Sørensen SA, Stokholm J, Nielsen J, Hiivola H, Martikainen K, Tuuha K, Peippo M, Sipponen M, Ignatius J, Kärppä M, Åman J, Santala M, Allain P, Guérid MA, Gohier B, Olivier A, Prundean A, Scherer Gagou C, Verny C, Babiloni B, Debruxelles S, Goizet C, Lafoucrière D, De Bruycker C, Carette AS, Decorte E, Delval A, Delliaux M, Dujardin K, Peter M, Plomhouse L, Simonin C, Thibault Tanchou S, Bellonet M, Duru C, Krystkowiak P, Roussel M, Wannepain S, Azulay JP, Chabot C, Delphini M, Eusebio A, Grosjean H, Mundler L, Nowak M, Rudolf G, Steinmetz G, Tranchant C, Wagner C, Zimmermann MA, Calvas F, Cheriet S, Démonet JF, Galitzky M, Kosinski CM, Milkereit E, Probst D, Sass C, Schiefer J, Schlangen C, Werner CJ, Gelderblom H, Priller J, Prüss H, Spruth EJ, Andrich J, Hoffmann R, Kraus PH, Muth S, Prehn C, Saft C, Salmen S, Stamm C, Steiner T, Strassburger K, Lange H, Friedrich A, Hunger U, Löhle M, Ganos C, Schrader C, Reilmann R, Landwehrmeyer B, Capellari S, Rizzo G, Sorbi S, Abbruzzese G, Di Maria E, Mandich P, Albanese A, Di Bella D, Gellera C, Mariotti C, Rinaldi C, Russo CV, Cannella M, Catalli C, ROMANO, SILVIA, Frich J, Slawek J, Wójcik M, Janik P, Rakowicz M, Witkowski G, Januário C, Cavaco S, Gago M, Barrero F, Calopa M, Gorospe A, Mir P, Paucar M, Svenningsson P, Tedroff J, Kaelin A, Schüpbach M, Miedzybrodzka Z, Busse M, Rosser A, Lahiri N, Tabrizi S, Wild E   +242 more
core   +12 more sources

How to Capitalize on the Retest Effect in Future Trials on Huntington's Disease. [PDF]

PLoS ONE, 2015
The retest effect-improvement of performance on second exposure to a task-may impede the detection of cognitive decline in clinical trials for neurodegenerative diseases.
Catherine Schramm, Sandrine Katsahian, Katia Youssov, Jean-François Démonet, Pierre Krystkowiak, Frédéric Supiot, Christophe Verny, Laurent Cleret de Langavant, Anne-Catherine Bachoud-Lévi, European Huntington's Disease Initiative Study Group and the Multicentre Intracerebral Grafting in Huntington's Disease Group   +9 more
doaj   +2 more sources

Reduced cancer Incidence in Huntington's disease. analysis in the registry study [PDF]

, 2018
People with Huntington's disease (HD) have been observed to have lower rates of ...
McNulty, Paul, Jones, Lesley, Romano, Silvia, Ferraldeschi, Michela, Dumoulin, Christine, Ramesh, Raviram, Gillardin, Anne-Françoise, Constant, Eric, Holmans, Peter, Hughes, Alis, Léonard, Marie-Claude, REGISTRY Investigators of the European Huntington's Disease Network, Ristori, Giovanni, van de Wyngaerde, Françoise, Pilcher, Richard, Farewell, Daniel, Necuiniate, Renata   +16 more
core   +2 more sources

Bioinformatic analysis of a microRNA regulatory network in Huntington's disease [PDF]

Journal of Integrative Neuroscience, 2020
Huntington's disease is an autosomal dominant hereditary neurodegenerative disease characterized by progressive dystonia, chorea and cognitive or psychiatric disturbances.
Zhi-Min Wang, Xiao-Yu Dong, Shu-Yan Cong
doaj   +1 more source

Metacognitive insight into cognitive performance in Huntington’s disease gene carriers

BMJ Neurology Open, 2022
Objectives Insight is an important predictor of quality of life in Huntington’s disease and other neurodegenerative conditions. However, estimating insight with traditional methods such as questionnaires is challenging and subjected to limitations.
Roger A Barker, Sarah L Mason, Samuel RC Hewitt, Alice J White   +3 more
doaj   +1 more source

A Triple Insider's Take on Arts Therapy, Arts-based Community Development, and Huntington's Disease

Voices, 2015
In this article, I reflect on my experiences as someone with Huntington's Disease who works professionally as a development ethnomusicologist, and who creates musical, video, and graphic arts for healing in communities I know.
Brian Schrag
doaj   +1 more source

Longitudinal diffusion tensor imaging shows progressive changes in white matter in Huntington’s disease [PDF]

, 2015
This work has been supported by the European Union — PADDINGTON project and all authors, with the exception of RS, SG and HZ receive funding from this project.
Scahill, Rachael I, Zhang, Hui, Roos, Raymund AC, Cole, James H, Sprengelmeyer, R, Hobbs, NZ, Cole, JH, Frost, Chris, Gregory, Sarah, Farmer, Ruth E., Hobbs, Nicola Z., Roos, Raymond A. C., Scahill, Rachel I., Cole, James H., Durr, Alexandra, Landwehrmeyer, B, Sprengelmeyer, Reiner, Rees, Elin M., Roos, RA, Scahill, Rachael I., Rees, EM, Landwehrmeyer, Bernhard, Tabrizi, Sarah J, Frost, C, Scahill, RI, Hobbs, Nicola Z, Gregory, S, Farmer, RE, Roos, Raymund A.C., Cole, James H.; id_orcid, Sprengelmeyer, Reiner Heinrich, Durr, A, Tabrizi, SJ, Tabrizi, Sarah J., Farmer, Ruth E, Rees, Elin M, Duerr, Alexandra, Zhang, H   +37 more
core   +1 more source

Proteostasis in striatal cells and selective neurodegeneration in Huntington’s disease

Frontiers in Cellular Neuroscience, 2014
Selective neuronal loss is a hallmark of neurodegenerative diseases, including Huntington’s disease (HD). Although mutant huntingtin, the protein responsible for Huntington’s disease, is expressed ubiquitously, a subpopulation of neurons in the striatum ...
Julia eMargulis, Julia eMargulis, Steven eFinkbeiner, Steven eFinkbeiner, Steven eFinkbeiner   +4 more
doaj   +1 more source

Mutant huntingtin fragmentation in immune cells tracks Huntington's disease progression. [PDF]

, 2012
Huntington's disease (HD) is a fatal, inherited neurodegenerative disorder caused by an expanded CAG repeat in the gene encoding huntingtin (HTT). Therapeutic approaches to lower mutant HTT (mHTT) levels are expected to proceed to human trials, but ...
Salman Haider, Weiss, A, Rachael I. Scahill, Sarah J. Tabrizi, Ulrike Träger, Bates, G, Stephan Grueninger, Wild, Edward J., Weiss, Andreas, Scahill, R, Ralph Andre, Farmer, Ruth, Macdonald, Douglas, Haider, Salman, Macdonald, D, Scahil, Rachael I., Grueninger, Stephan, Chris Frost, Frost, C, Farmer, R, Wild, E, Bilbe, G, Tabrizi, SJ, Ruth Farmer, Tabrizi, Sarah J., Landles, C, Nayana Lahiri, Gillian P. Bates, Edward J. Wild, Scahill, Rachael I, Douglas Macdonald, Rainer Kuhn, Andre, R, Frost, Chris, Kuhn, R, Grueninger, S, Bates, GP, Wild, Edward J, Wild, EJ, Kuhn, Rainer, Graeme Bilbe, Träger, U, Andreas Weiss, Christian Landles, Lahiri, N, Tabrizi, Sarah J, Scahill, RI, Andre, Ralph, Landles, Christian, Traeger, Ulrike, Lahiri, Nayana, Träger, Ulrike, Bilbe, Graeme, Haider, S, Bates, Gillian P, Bates, Gillian P.   +55 more
core   +1 more source

Cholinergic deficits selectively boost cortical intratelencephalic control of striatum in male Huntington’s disease model mice

Nature Communications, 2023
The corticostriatal dysfunction underlying Huntington’s disease remains incompletely understood. Here, the authors find increased intratelencephalic connectivity resulting from deficient cholinergic transmission in a mouse model of Huntington’s disease.
Tristano Pancani, Michelle Day, Tatiana Tkatch, David L. Wokosin, Patricia González-Rodríguez, Jyothisri Kondapalli, Zhong Xie, Yu Chen, Vahri Beaumont, D. James Surmeier   +9 more
doaj   +1 more source