Results 31 to 40 of about 57,910 (287)
Neuropsychiatric Aspects of Huntington’s Disease
Psikiyatride Güncel Yaklaşımlar, 2022 Huntington’s Disease is a progressive neurodegenerative disorder inherited in an autosomal dominant fashion with distinct phenotypesas chorea and dystonia, incoordination, cognitive disorders, and behavioural problems.
Özlem Devrim Balaban +1 more
doaj +1 more source
The Unfolded Protein Response and its potential role in Huntington's disease [PDF]
, 2012 Huntington's disease (HD) is a progressive, neurodegenerative disease with fatal outcome. Although the disease-causing gene (huntingtin) has been known for some time, the exact cause of neuronal cell death is still unknown.
Kamesh Ayasolla +2 more
core +2 more sources
Longitudinal study of informed consent in innovative therapy research: experience and provisional recommendations from a multicenter trial of intracerebral grafting. [PDF]
PLoS ONE, 2015 There is an urgent need to assess and improve the consent process in clinical trials of innovative therapies for neurodegenerative disorders.We performed a longitudinal study of the consent of Huntington's disease patients during the Multicenter Fetal ...
Laurent Cleret de Langavant +12 more
doaj +1 more source
How young people find out about their family history of Huntington's disease [PDF]
, 2009 Family communication about adult-onset hereditary illness can be problematic, leaving some relatives inadequately informed or ignorant of their risk.
Forrest Keenan, Karen +4 more
core +1 more source
PLoS ONE, 2015 Huntington's disease is a fatal neurodegenerative condition caused by a CAG repeat expansion in the huntingtin gene. The peripheral innate immune system is dysregulated in Huntington's disease and may contribute to its pathogenesis.
James R C Miller +3 more
doaj +1 more source
MRI findings in juvenile Huntington's disease
Radiology Case Reports, 2021 Juvenile Huntington's disease is a rare neurodegenerative disorder that first affects the basal ganglia. Presented here is a case of juvenile Huntington's disease in an 8-year-old male. Clinical features included epilepsy and developmental delay. Imaging
Patrick Arraj, BS +4 more
doaj +1 more source
Silencing Huntington's chorea: Is RNA Interference a Potential Cure? [PDF]
Impulse: The Premier Undergraduate Neuroscience Journal, 2006 In 1872, George Huntington described Huntington's disease as characterized by motor, cognitive and psychiatric impairments. Huntington's disease is a dominant and autosomal mutation on chromosome 4 featuring the insertion of numerous CAG repeats.
Gerlinde A. Metz +3 more
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Revista Finlay, 2023 Foundation: biomarkers of oxidative stress in Huntington's disease could predict the course of the disease and evaluate new treatments, but their nonspecific nature seems to prevent the identification of any useful marker.
Marisol Peña Sánchez +5 more
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Heliyon, 2021 Huntington's disease is a neurodegenerative disease caused by CAG repeat in the first exon of HTT (Huntingtin) gene, leading to abnormal form of Htt protein containing enlarged polyglutamine strands of variable length that stick together to form ...
Harleen Kohli +2 more
doaj +1 more source
Experimental and Molecular Medicine, 2019 Huntington’s disease: Diabetes drug limits disease-related degeneration in mice Metformin, an existing drug for diabetes, shows promise in alleviating symptoms of early Huntington’s disease in mouse models. Huntington’s disease is a genetic disorder that
Ana Sanchis +6 more
doaj +1 more source