Results 41 to 50 of about 37,609 (272)

Factor analysis of the hospital anxiety and depression scale among a Huntington's disease population

, 2015
Introduction: Depression and anxiety are common in Huntington's disease, a genetic neurodegenerative disorder. There is a need for measurement tools of mood to be validated within a Huntington's disease population.
ROMANO, SILVIA, Shimozaki, Steve, Maltby, John, Martucci, Rossana, Registry, investigators of theEuropean Huntington's Disease Network, Dale, Maria   +5 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Huntington’s disease: Neuropsychiatric manifestations of Huntington’s disease [PDF]

Australasian Psychiatry, 2018
Objectives: Huntington’s disease (HD) is a profoundly incapacitating, and ultimately fatal, neurodegenerative disease. HD is presently incurable, so the current goal is to allow affected individuals to live as well as possible with the illness, to maximise functional independence and quality of life for the ...
Anita MY Goh, Pierre Wibawa, Samantha M Loi, Mark Walterfang, Dennis Velakoulis, Jeffrey CL Looi   +5 more
openaire   +3 more sources

Visual system integrity and cognition in early Huntington's disease

, 2014
Posterior cortical volume changes and abnormal visuomotor performance are present in patients with Huntington's disease (HD). However, it is unclear whether posterior cortical volume loss contributes to abnormal neural activity, and whether activity ...
Landwehrmeyer, G Bernhard, Ratheiser I., Süssmuth, Sigurd D., Orth, Michael, Depping, Malte S, Nenad Vasic, Wolf, Robert C, Ratheiser, Iris, Iris Ratheiser, Vasic N., Sigurd D. Süssmuth, Depping M. S., Thomann P. A., Thomann, Philipp A., Malte S. Depping, Bernhard Landwehrmeyer, Georg, Süssmuth, Sigurd S, Georg Bernhard Landwehrmeyer, Sprengelmeyer R., Sprengelmeyer, Reiner, Fabio Sambataro, Vasic, Nenad, Sambataro, Fabio, Thomann, Philipp A, Orth M., Depping, Malte S., Philipp A. Thomann, Eva‐Maria Baldas, Reiner Sprengelmeyer, Wolf R. C., Sprengelmeyer, Reiner Heinrich, Robert C. Wolf, Bernhard Landwehrmeyer G., Baldas, Eva Maria, Michael Orth, Baldas E. -M., Sambataro F., Baldas, Eva-Maria, Sussmuth S. D.   +38 more
core   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Neuropsychiatric Aspects of Huntington’s Disease

Psikiyatride Güncel Yaklaşımlar, 2022
Huntington’s Disease is a progressive neurodegenerative disorder inherited in an autosomal dominant fashion with distinct phenotypesas chorea and dystonia, incoordination, cognitive disorders, and behavioural problems.
Özlem Devrim Balaban, E. Cem Atbaşoğlu   +1 more
doaj   +1 more source

Huntington's Disease. Prevalence and Psychological Indicators of Pain

, 2017
Background Huntington's disease (HD) is a genetic neurodegenerative condition that involves impairments in movement, cognition, and mood. Research is lacking in HD with regard to the prevalence of pain and the relationships between psychological factors
Underwood, Mandy, Giovanni, Ristori, REGISTRY Investigators of the European Huntington's Disease Network, Michela, Ferraldeschi, Romano, Silvia., Dale, Maria, Bonas, Sheila   +6 more
core   +1 more source

Stem Cells for Huntington's Disease (SC4HD): An International Consortium to Facilitate Stem Cell-Based Therapy for Huntington's Disease [PDF]

, 2022
Huntington's disease (HD) research is entering an exciting phase, with new approaches such as huntingtin lowering strategies and cell therapies on the horizon.
Gray, William, Li, Meng, Goldman, Steven A., Thompson, Leslie M., Lai, Liangxue, Cattaneo, Elena, Ellederova, Zdenka, Perpiñá Martin, Unai, Pei, Zhong, Song, Jiwhan, Canals i Coll, Josep M., Capetian, Philipp, Rosser, Anne E., Chen, Jefferson, Reidling, John C., SC4HD Consortium, Aron Badin, Romina, Cozzi, Emanuele, Busse-Morris, Monica, Morenkova, Anna, Bachoud-Lévi, Anne-Catherine, Pang, Guangjin, Wheelock, Vicki, Bauer, Gerhard, Perrier, Anselme   +24 more
core   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

A psychometric comparison of two Carer Quality of Life Questionnaires in Huntington's disease [Elektronisk resurs] : implications for neurodegenerative disorders

, 2013
Background: The carer impact of neurodegenerative disorders such as Huntington's disease (HD) is vast. Attempts to measure carer QoL in neurodegenerative disorders include the three-dimensional (Practical aspects of Caregiving, PC; Satisfaction with Life,
Hagell, Peter,, Smith, Stephen,, Kristianstad University.   +2 more
core   +2 more sources