Results 51 to 60 of about 4,891,805 (263)

Copine‐4 Paraneoplastic Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We characterize copine‐4 (CPNE4)‐IgG and report clinical associations. Among 844 samples with unclassified neural IgGs identified by mouse‐brain indirect immunofluorescence assay over 2 years, 5 samples (serum, 3; CSF, 2) from 3 patients produced a distinctive cerebrum‐restricted synaptic pattern.
Mimi S. Fang, Amy Ml Quek, Clement Yong, Amir Adeli, Gabrielle N. Conway, Connie E. Lesnick, Diana Anissian, Divyanshu Dubey, John R. Mills, Sean J. Pittock, Anastasia Zekeridou, Michael Gilligan, Andrew McKeon   +12 more
wiley   +1 more source

A psychometric comparison of two Carer Quality of Life Questionnaires in Huntington's disease [Elektronisk resurs] : implications for neurodegenerative disorders

, 2013
Background: The carer impact of neurodegenerative disorders such as Huntington's disease (HD) is vast. Attempts to measure carer QoL in neurodegenerative disorders include the three-dimensional (Practical aspects of Caregiving, PC; Satisfaction with Life,
Hagell, Peter,, Smith, Stephen,, Kristianstad University.   +2 more
core   +2 more sources

Huntington's Disease. Prevalence and Psychological Indicators of Pain

, 2017
Background Huntington's disease (HD) is a genetic neurodegenerative condition that involves impairments in movement, cognition, and mood. Research is lacking in HD with regard to the prevalence of pain and the relationships between psychological factors
Underwood, Mandy, Giovanni, Ristori, REGISTRY Investigators of the European Huntington's Disease Network, Michela, Ferraldeschi, Romano, Silvia., Dale, Maria, Bonas, Sheila   +6 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Biomarkers for Huntington's disease: an update [PDF]

, 2012
Huntington's disease (HD) is a devastating autosomal-dominant neurodegenerative condition caused by a CAG repeat expansion in the gene encoding huntingtin which is characterised by progressive motor impairment, cognitive decline and neuropsychiatric ...
Wild, EJ, Tabrizi, SJ, Scahill, RI
core  

Factor analysis of behavioural symptoms in Huntington's disease

, 2011
A principal-components factor analysis was performed on behavioural data obtained from the European Huntington's Disease Network REGISTRY study. 1690 valid assessments using the United Huntington's Disease Rating Scale Behavioural Rating Scale were ...
ROMANO, SILVIA, Simpson, Sheila A., De Souza, Jenny, Van Walsem, Marleen, Landwehrmeyer, Bernhard, Van Duijn, Erik, European Huntington's Disease Network, Rickards, Hugh, SQUITIERI, Ferdinando   +8 more
core   +1 more source

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

Clinical impairment in premanifest and early Huntington's disease is associated with regionally specific atrophy.

, 2011
TRACK-HD is a multicentre longitudinal observational study investigating the use of clinical assessments and 3-Tesla magnetic resonance imaging as potential biomarkers for future therapeutic trials in Huntington's disease (HD).
Stout, J.C., Roos, Raymund AC, TRACK-HD investigators, Sarah J. Tabrizi, Langbehn, DR, David Craufurd, Langbehn, Douglas R, Callaghan, Jenny, Blair R. Leavitt, Alexandra Durr, Reilmann, R, Frajman, Ellen, Say, Miranda J, Henley, Susie M D, Johnson, H., Scahill, R.I., Roos, R.A.C., Rebecca Jones, Stephen L. Hicks, Craufurd, David, Keenan, Siobhan, Whitlock, Kathryn, Susie M.D. Henley, Fox, Nick, Queller, Sarah, Sturrock, Aaron, Say, M.J., Hobbs, N.Z., Milchman, Cassie, t'Hart, Ellen, Craufurd, D, Tabrizi, S.J., Bechtel, N., null null, Owen, Gail, Tabrizi, SJ, Leavitt, B.R., Miranda J. Say, Coleman, Allison, Henley, Susie MD, Jones, R., Jauffret, Céline, Hobbs, NZ, Landwehmeyer, Bernhard, Hyare, H., Jones, Rebecca, Wang, Chiachi, Natalie Bechtel, Dar Santos, Rachelle, Bechtel, N, Rosas, H Diana, Douglas R. Langbehn, Raymund A.C. Roos, Lehericy, S., Durr, A., Hoffman, Arndt, Bechtel, Natalie, Hicks, S.L., Christopher Kennard, Julie C. Stout, Stout, JC, Kennard, C, Henley, SM, Pepple, Tracey, Campbell, Colin, Langbehn, D.R., Jones, R, Rachael I. Scahill, Arran, Natalie, Reilmann, R., Harpreet Hyare, Lee, Stephanie, Henley, S.M.D., Durr, Alexandra, Ralf Reilmann, Campbell, Melissa, Mills, Jim, Axelson, Eric, Monaco, William, Hobbs, Nicola Z, Nicola Z. Hobbs, Bardinet, Eric, Say, MJ, Hicks, SL, Durr, A, Johnson, H, van Bogaard, Simon J A, Scahill, Rachael I, Lehéricy, S, Stout, Julie C, Leavitt, Blair R, Hyare, H, Valabre, Romain, Read, Joy, Ordidge, Roger, Hyare, Harpreet, Craufurd, D., Lehéricy, Stéphane, Decolongon, Joji, Stéphane Lehéricy, Roos, RA, Roos, Raymund A C, van der Grond, Jeroen, Kennard, C., Tabrizi, Sarah J, O'Regan, Alison, Scahill, RI, Marelli, Cecilia, Dumas, Eve, Lahiri, Nayana, Kennard, Christopher, Leavitt, BR, Hans Johnson, Reilmann, Ralf, Justo, Damian, Nigaud, Kevin, Johnson, Hans, Hicks, Stephen L   +117 more
core   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Malestar psicológico en portadores y no portadores de la mutación causante de enfermedad de Huntington y su relación con la carga de la enfermedad

Neurología
Resumen: Introducción: La enfermedad de Huntington (EH) es un trastorno neurodegenerativo y hereditario. A partir del diagnóstico predictivo se han descrito características clínicas incipientes en la fase prodrómica, y varios estudios han reportado ...
Y. Rodríguez-Agudelo, M. Chávez-Oliveros, A. Ochoa-Morales, L. Martínez-Ruano, A. Camacho-Molina, F. Paz-Rodríguez   +5 more
doaj   +1 more source