Results 71 to 80 of about 37,609 (272)

Suicidal ideation and suicidal behavior according to the C-SSRS in a European cohort of Huntington's disease gene expansion carriers

, 2018
Background Huntington's disease (HD) gene expansion carriers are at an increased risk of suicide, but so far, no studies have investigated the full spectrum of suicidality, including suicidal ideation, suicidal behavior and self-injurious behavior ...
van Duijn, Erik, Giltay, Erik J., Vrijmoeth, Eslie M., Silvia, Romano., Giovanni, Ristori, Bernhard Landwehrmeyer, G, Michela, Ferraldeschi, REGISTRY investigators of the European Huntington's Disease Network   +7 more
core   +1 more source

Palmitoylation of PSD‐95 Orchestrates Learning‐Dependent Metaplasticity in the Amygdala and Fear Memory

Advanced Science, EarlyView.
This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Zu‐Cheng Shen, Yu‐Xuan Weng, Zhi‐Xuan Xia, Yue‐Ling Zhao, Qian‐Qian Ding, Si‐Ying Wang, Ting Cao, Xuan‐Ying Chen, Wu‐Cheng Tao, Shen Lin, Zhou Chen, Yi‐Xiao Luo   +11 more
wiley   +1 more source

The human olfactory bulb in Huntington's disease: sex-specific differences in volume and gliosis

Neurobiology of Disease
Huntington's disease is a multisystemic neurodegenerative disorder for which increasing evidence suggests early involvement of brain regions beyond the primarily affected motor areas of the brain, such as the olfactory bulb, which is affected by multiple
Ana Paula Flores-Thomas, Elena Retamosa-Sanchez, Andrea Alonso-Gomez, Alicia Flores-Cuadrado, Daniel Saiz-Sanchez, Veronica Astillero-Lopez, Alberto Rabano, Alino Martinez-Marcos, Isabel Ubeda-Banon   +8 more
doaj   +1 more source

Reliability and validity of the Huntington's Disease Everyday Functioning (Hi-DEF): A patient-reported measure of cognitive capacity on daily functioning in Huntington's disease. [PDF]

J Huntingtons Dis
Background The Huntington's Disease (HD) Everyday Functioning (Hi-DEF) is a novel patient-reported outcome (PRO) scale developed to assess the impact of cognitive impairment on daily functioning in early HD patients.Objective To examine the psychometric ...
Petrillo J, Sawant R, Rogers R, Cleanthous S, Cano S, Kumar R, Klapper J, Sierra LA, Bang J, Anderson KE, Hall DA, Perlman S, Moore H, Bega D, Johannesen J, Elliott E.   +15 more
europepmc   +2 more sources

The Prevalence of Huntington's Disease [PDF]

Neuroepidemiology, 2016
<b><i>Background:</i></b> Reviews of the epidemiology of Huntington's disease (HD) suggest that its worldwide prevalence varies widely. This review was undertaken to confirm these observations, to assess the extent to which differences in case-ascertainment and/or diagnosis might be responsible, and to investigate whether the ...
Rawlins, Michael D, Wexler, Nancy S, Wexler, Alice R, Tabrizi, Sarah J, Douglas, Ian, Evans, Stephen JW, Smeeth, Liam   +6 more
openaire   +2 more sources

Perinatal insults and neurodevelopmental disorders may impact Huntington's disease age of diagnosis [PDF]

, 2018
Introduction: The age of diagnosis of Huntington's disease (HD) varies among individuals with the same HTT CAG-repeat expansion size. We investigated whether early-life events, like perinatal insults or neurodevelopmental disorders, influence the ...
Rodrigues FB, Anderson DG, Ferraldeschi M, Wild EJ, Gavilanes AWD., Ristori G, Barkhuizen M, Kramer BW, REGISTRY Investigators of the European Huntington's Disease Network, Winkens B, Romano S   +10 more
core   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Exosome‐mediated gut–brain axis signaling in neurodegenerative diseases: Mechanisms, experimental evidence, and therapeutic perspectives—A narrative review

Animal Models and Experimental Medicine, EarlyView.
The gut–brain axis is a bidirectional communication network between the intestines and brain, mediated by gut microbiota and exosomes, that regulates neuroinflammation, protein aggregation, and neuronal health processes central to neurodegenerative diseases.
Waheeb Sami Aggad, Rakesh Ghosh, Hailah M. Almohaimeed, Zuhair M. Mohammedsaleh, Fayez M. Saleh, Amany I. Almars, S. Renuka Jyothi, Rajashree Panigrahi, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

Animal models in molecular biology research: Challenges, ethical imperatives, and the path to human‐relevant translation

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract shows how molecular biology research has shifted from using traditional animal models toward using methods that are more relevant to humans. It points out the main problems, differences between species, difficulty in reproducing results, moral issues, and lack of infrastructure that make translational accuracy harder to achieve ...
Md. Shajid Hossain Rafi, Md. Taslim Sarker, Ferdous‐Ul‐Haque Joy, Shahriar Mohd Shams, Tahmina Foyez, Md. Abdul Mazid, Syed Masudur Rahman Dewan   +6 more
wiley   +1 more source

Biomarkers for Huntington's disease: an update

, 2012
Huntington's disease (HD) is a devastating autosomal-dominant neurodegenerative condition caused by a CAG repeat expansion in the gene encoding huntingtin which is characterised by progressive motor impairment, cognitive decline and neuropsychiatric ...
Wild, EJ, Tabrizi, SJ, Scahill, RI
core