Results 91 to 100 of about 4,891,805 (263)

The Neuropsychology of Huntington's Disease [PDF]

Archives of Clinical Neuropsychology, 2017
Huntington's disease is an inherited, degenerative brain disease, characterized by involuntary movements, cognitive disorder and neuropsychiatric change. Men and women are affected equally. Symptoms emerge at around 40 years, although there is wide variation. A rare juvenile form has onset in childhood or adolescence.
openaire   +2 more sources

Irritability in huntington's disease: factor analysis of Snaith's irritability scale

, 2017
Background Elevated levels of irritability are reported to occur in a number of neurological conditions, including Huntington's disease (HD), a genetic neurodegenerative disorder.
Underwood, Mandy, Silvia, Romano., the REGISTRY investigators of the European Huntington's Disease Network, Giovanni, Ristori, Maltby, John, Simpson, Jane, Michela, Ferraldeschi, Dale, Maria   +7 more
core   +1 more source

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
wiley   +1 more source

Major Superficial White Matter Abnormalities in Huntington disease

Frontiers in Neuroscience, 2016
BackgroundThe late myelinating superficial white matter at the juncture of the cortical gray and white matter comprising the intracortical myelin and short-range association fibers has not received attention in Huntington’s disease.
Owen Robert Phillips, Owen Robert Phillips, Shantanu H Joshi, Ferdinando eSquitieri, Ferdinando eSquitieri, Cristina eSanchez-Castaneda, Katherine eNarr, David W Shattuck, Carlo eCaltagirone, Carlo eCaltagirone, Umberto eSabatini, Margherita eDi Paola, Margherita eDi Paola   +12 more
doaj   +1 more source

Stability effects on results of diffusion tensor imaging analysis by reduction of the number of gradient directions due to motion artifacts: an application to presymptomatic Huntington's disease. [PDF]

, 2011
In diffusion tensor imaging (DTI), an improvement in the signal-to-noise ratio (SNR) of the fractional anisotropy (FA) maps can be obtained when the number of recorded gradient directions (GD) is increased.
Müller, HP, Kassubek, J, Landwehrmeyer, GB, Kloppel, S, Tabrizi, SJ, Süssmuth, SD, Ludolph, A   +6 more
core  

Depressive Symptoms, sleep Disturbance, and Cardiometabolic Multimorbidity Among Adults With Arthritis: A Cross‐Sectional Analysis of NHANES 2013–2020

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT While the association between depressive symptoms and cardiometabolic disease is well established, the relationships among depressive symptoms, sleep disturbance, and cardiometabolic multimorbidity (CMM) in adults with arthritis remain insufficiently understood.
Lu‐Niao Ma, Jing‐Cheng Jiang, Jun‐Jie Lan, Yang‐Yang Chen, Hui‐Min Zhang, Yao Zeng, Xu‐Hui Huang, Xiao‐Na Tang   +7 more
wiley   +1 more source

Discrepancies in reporting the CAG repeat lengths for Huntington's disease.

, 2012
Huntington's disease results from a CAG repeat expansion within the Huntingtin gene; this is measured routinely in diagnostic laboratories. The European Huntington's Disease Network REGISTRY project centrally measures CAG repeat lengths on fresh samples;
Quarrel O. W., Kline M., Ramos Arroyo M., Landwehrmeyer G. B., CAPELLARI, SABINA, Dumoulin C., European Huntington's Disease Network, Biunno I., CORTELLI, PIETRO, Bauer P., O'Donovan K., Handley O., GALLASSI, ROBERTO   +12 more
core   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Survival, mortality, causes and places of death in a european huntington's disease prospective cohort

, 2017
Background Huntington's disease (HD) is a rare and fatal inherited genetic disorder characterized by progressive motor, cognitive, and behavioral impairment. It leads to premature death, but data regarding advanced‐stage disease are scarce. We sought to
Abreu, Daisy, Giovanni, Ristori, Rodrigues, Filipe Brogueira, Ferreira, Joaquim J., Coelho, Miguel, REGISTRY Investigators of the European Huntington's Disease Network, Michela, Ferraldeschi, Goncalves, Nilza, Correia-Guedes, Leonor, Damásio, Joana   +9 more
core   +1 more source

The Impact of Upcoming Treatments in Huntington's Disease: Resource Capacity Limitations and Access to Care Implications.

, 2021
BACKGROUND The most advanced disease-modifying therapies (DMTs) in development for Huntington's disease (HD) require intrathecal (IT) administration, which may create or exacerbate bottlenecks in resource capacity.
Guttman, Mark, Reilmann, Ralf, Burgunder, Jean-Marc, Nordström, Anna-Lena, Pelletier, Marsha, Pedrazzoli, Marco, Ponomareva, Marina, Townson, Louisa, Levine, Aaron, Mukelabai, Kopano   +9 more
core   +1 more source