Results 111 to 120 of about 4,891,805 (263)

Exploration of the genetic neuroinflammatory environment in the human midcingulate cortex in Huntington’s disease

Communications Medicine
Background Despite progress, the pathophysiology involving neuroinflammation in Huntington’s disease remains uncertain, and the genetic environment of the midcingulate cortex in the disease has not been investigated.
Mackenzie W. Ferguson, Shelley Scheepers, Thulani Palpagama, Malvindar Singh-Bains, Aodán Laighneach, Derek W. Morris, Clinton Turner, Lynette Tippett, Henry J. Waldvogel, Richard L. M. Faull, Andrea Kwakowsky   +10 more
doaj   +1 more source

Predicting the Risk of Huntington's Disease with Multiple Longitudinal Biomarkers.

, 2019
BACKGROUND:Huntington's disease (HD) has gradually become a public health threat, and there is a growing interest in developing prognostic models to predict the time for HD diagnosis.
Li, Fan, PREDICT-HD and ENROLL-HD Investigators of the Huntington Study Group, Li, Kan, Li, Cai, Luo, Sheng   +4 more
core   +1 more source

The DIKW of Transcriptomics in Ecotoxicology: Extracting Information, Knowledge, and Wisdom From Big Data

Environmental Toxicology and Chemistry, EarlyView.
Jessica A. Head, Jessica D. Ewald, Niladri Basu   +2 more
wiley   +1 more source

Acute and Chronic Local Field Potential Recordings in Dystonia—A Systematic Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Dystonia is a hyperkinetic movement disorder increasingly conceptualized as a disorder of distributed network dysfunction involving the basal ganglia, cortex and cerebellum. Local field potentials (LFPs) recorded from deep brain stimulation (DBS) electrodes provide a unique opportunity to characterize the electrophysiological signatures ...
Jack Horan, Eoghan Donlon, Aoibheann Gill, Rosalyn Moran, Conor Fearon, Richard A. Walsh, Catherine Moran   +6 more
wiley   +1 more source

Striato-cortical connectivity patterns predict clinical profiles in Huntington’s disease

NeuroImage: Clinical
Background: Huntington’s disease is an inherited neurodegenerative disorder affecting striato-cortical circuits, with significant heterogeneity in the severity and progression of symptoms and neurodegenerative patterns.
Audrey E. De Paepe, Vasiliki Bikou, Eylül Turan, Alexis Pérez-Bellido, Clara Garcia-Gorro, Nadia Rodriguez-Dechicha, Irene Vaquer, Matilde Calopa, Ruth de Diego-Balaguer, Estela Camara   +9 more
doaj   +1 more source

Bioinformatics analysis of the molecular mechanism underlying Huntington's disease

Journal of Integrative Neuroscience, 2019
We explore the underlying molecular mechanisms and to identify key molecules in Huntington's disease by utilizing bioinformatics methods. The gene expression profile of GSE3621 was extracted from the gene expression omnibus.
Zhimin Wang, Xiaoyu Dong, Shuyan Cong
doaj   +1 more source

Pyramidal Cell Loss in Motor Cortices in Huntington's Disease

Neurobiology of Disease, 2002
Patterns of huntingtin protein aggregation and cortical neuronal loss suggest early involvement of corticostriatal pathways in Huntington's disease. However, theories of pathogenesis of chorea rely on the motor cortices being intact.
Virginia Macdonald, Glenda Halliday
doaj   +1 more source

Interregional compensatory mechanisms of motor functioning in progressing preclinical neurodegeneration. [PDF]

, 2013
Understanding brain reserve in preclinical stages of neurodegenerative disorders allows determination of which brain regions contribute to normal functioning despite accelerated neuronal loss.
Scheller, Elisa, Peter, J, Peter, Jessica, Scheller, E., Peter, J., Abdulkadir, Ahmed, Frackowiak, Richard S. J., Frackowiak, R.S., Klöppel, Stefan, Tabrizi, S.J., Frackowiak, Richard S.J., Abdulkadir, A, Tabrizi, SJ, Frackowiak, RS, Scheller, E, Klöppel, S., Tabrizi, Sarah J., Abdulkadir, A., Klöppel, S   +18 more
core   +1 more source

Breathe, Eat, Talk: Three Essential Ingredients to Quality‐of‐Life Outcomes in Movement Disorders

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Breathing, eating, and talking (BET) impairments are common yet frequently underrecognized features of movement disorders. Deficits in respiration, swallowing, voice, and speech may emerge early in the course of a disease, adversely affecting safety, participation, and quality of life.
John Dean, Lena C. O’Flynn, Michelle Ciucci, Cynthia Fox, Jessica E. Huber, Supraja Anand, Maira Rozenfeld Olchik, Jibrin S. Usman, Adam P. Vogel, Bettina Aguiar, Diana Khasanova, Dharshini Manoharan, Lorraine Ramig, Angela Roberts, Federico Rodriguez‐Porcel, Kristina Simonyan, Julie M. Barkmeier‐Kraemer   +16 more
wiley   +1 more source

Automatic selection model to identify neurodegenerative diseases

Digital Health
Objective This study evaluates machine learning algorithms’ effectiveness in classifying Parkinson’s disease and Huntington’s disease based on biomarker data obtained non-invasively from patients and healthy controls.
Eddy Sánchez-DelaCruz, Cecilia-Irene Loeza-Mejía, César Primero-Huerta, Mirta Fuentes-Ramos   +3 more
doaj   +1 more source