Results 101 to 110 of about 37,609 (272)

Survival, mortality, causes and places of death in a european huntington's disease prospective cohort

, 2017
Background Huntington's disease (HD) is a rare and fatal inherited genetic disorder characterized by progressive motor, cognitive, and behavioral impairment. It leads to premature death, but data regarding advanced‐stage disease are scarce. We sought to
Abreu, Daisy, Giovanni, Ristori, Rodrigues, Filipe Brogueira, Ferreira, Joaquim J., Coelho, Miguel, REGISTRY Investigators of the European Huntington's Disease Network, Michela, Ferraldeschi, Goncalves, Nilza, Correia-Guedes, Leonor, Damásio, Joana   +9 more
core   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Major Superficial White Matter Abnormalities in Huntington disease

Frontiers in Neuroscience, 2016
BackgroundThe late myelinating superficial white matter at the juncture of the cortical gray and white matter comprising the intracortical myelin and short-range association fibers has not received attention in Huntington’s disease.
Owen Robert Phillips, Owen Robert Phillips, Shantanu H Joshi, Ferdinando eSquitieri, Ferdinando eSquitieri, Cristina eSanchez-Castaneda, Katherine eNarr, David W Shattuck, Carlo eCaltagirone, Carlo eCaltagirone, Umberto eSabatini, Margherita eDi Paola, Margherita eDi Paola   +12 more
doaj   +1 more source

Caregiver roles in families affected by Huntington's disease: a qualitative interview study [PDF]

, 2014
Aim: The objective of this study was to explore family caregivers' experiences with the impact of Huntington's disease (HD) on the family structure and roles in the family.
Malterud, Kirsti, Frich, Jan C., Røthing, Merete   +2 more
core   +1 more source

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

Journal of Intelligent Medicine, EarlyView.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
wiley   +1 more source

Striato-cortical connectivity patterns predict clinical profiles in Huntington’s disease

NeuroImage: Clinical
Background: Huntington’s disease is an inherited neurodegenerative disorder affecting striato-cortical circuits, with significant heterogeneity in the severity and progression of symptoms and neurodegenerative patterns.
Audrey E. De Paepe, Vasiliki Bikou, Eylül Turan, Alexis Pérez-Bellido, Clara Garcia-Gorro, Nadia Rodriguez-Dechicha, Irene Vaquer, Matilde Calopa, Ruth de Diego-Balaguer, Estela Camara   +9 more
doaj   +1 more source

Huntington's Disease Clinical Trials Corner: January 2019 [PDF]

, 2019
© 2019 – IOS Press and the authors. All rights reservedIn this edition of the Huntington's Disease Clinical Trials Corner we expand on the GENERATION-HD1 and PACE-HD trials, and we list all currently registered and ongoing clinical trials in Huntington's
Wild, Edward J., Quinn, L, Rodrigues, Filipe Brogueira, Quinn, Lori, Wild, E, Brogueira Rodrigues, F   +5 more
core   +1 more source

Genetic and Pathological Testing Attitudes for Parkinson's Disease in At‐Risk Relatives

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is increasingly recognized as a neurodegenerative disorder with a broad clinical spectrum and diverse biomarkers enabling early detection. α‐synuclein seed amplification assays (SAA) and genetic testing now allow identification of PD pathology in asymptomatic individuals.
Tal Weil, Anat Mirelman, Roy N. Alcalay, Nurit Omer, Penina Ponger, Avner Thaler   +5 more
wiley   +1 more source

Movement Disorders in Developmental and Epileptic Encephalopathies

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Monogenic developmental and epileptic encephalopathies (DEE) frequently feature co‐occurring movement disorders. Gene discovery has expanded epilepsy‐dyskinesia syndromes (EDS) from classic associations such as stereotypies in Rett syndrome to PRRT2‐related infantile seizures with paroxysmal dyskinesia and crouched gait in SCN1A ...
Shekeeb Mohammad, Darius Ebrahimi‐Fakhari, Hugo Morales‐Briceno   +2 more
wiley   +1 more source