Results 131 to 140 of about 4,891,805 (263)

ATXN8OS Intermediate Expansion Acts as a Genetic Modifier in Spinocerebellar Ataxia Type 48 (SCA48/STUB1)

Movement Disorders, EarlyView.
Abstract Background Association between monoallelic STUB1 variant and expanded ATXN8OS alleles was recently reported, suggesting a pathogenic interaction that may influence spinocerebellar ataxia type 48 (SCA48) phenotype. Objectives We investigated the frequency and clinical impact of ATXN8OS in a large cohort of STUB1 carriers compared to individuals
Charlotte Mouraux, Jean‐Loup Méreaux, Claire‐Sophie Davoine, Léna Guillot Noel, Emilien Petit, Quentin Thomas, Adem Nasraoui, Anna Heinzmann, Claire Ewenczyk, Alexis Brice, Alexandra Durr, Giulia Coarelli   +11 more
wiley   +1 more source

Time‐Resolved Effects of Cold Atmospheric Plasma on E. coli GW‐AmxH19 Transcriptome and Proteome in an Emulated Wastewater Environment

PROTEOMICS, EarlyView.
ABSTRACT Cold atmospheric plasma (CAP) is effective against a variety of microorganisms. Here, we described effects on an Escherichia coli strain isolated from hospital wastewater caused by treatment with physical plasma. E. coli GW‐AmxH19 was incubated in artificial wastewater and treated for 15 min with CAP.
Jörg Bernhardt, Dominik Schneider, Julia Rielicke, Susanne Sievers, Veronika Hahn, Mechthild Bömeke, Anja Poehlein, Dirk Albrecht, Juergen F. Kolb, Katharina Riedel, Rolf Daniel, Daniela Zühlke   +11 more
wiley   +1 more source

Huntington’s Disease and Psychiatric Comorbidities: A Retrospective Study in Portugal

Acta Médica Portuguesa
Introduction: Huntington’s disease is a progressive neurodegenerative disorder characterized by motor, cognitive, and behavioral symptoms. While psychiatric comorbidity is common and may influence disease outcomes, there is a lack of data on its ...
José Rocha, Carolina Soares, Manuel Gonçalves-Pinho   +2 more
doaj   +1 more source

Enhance food plant diversity conservation and use through greater coordination between genebanks and botanic gardens

PLANTS, PEOPLE, PLANET, EarlyView.
Food plants are vital to human and planetary health, but their diversity is threatened, making food security, nutrition, and environmental goals more difficult to achieve. Food plant diversity conservation, research, and education can be enhanced through collaboration between sectors, including genebanks and botanic gardens, which possess complementary
Colin K. Khoury, Sarah Gora, Hannes Dempewolf, Mauricio Diazgranados, Alex C. McAlvay, Vania Azevedo, Sam Brockington, Ángela Cano, Daniel Carver, Carly Cowell, Peter Crane, Cary Fowler, Peter Giovannini, Luigi Guarino, Robbie Hart, Geoff Hawtin, Sarada Krishnan, Charlotte Lusty, Patricia Malcolm, Nan McCarry, Abby Meyer, Allison Miller, Ray Mims, Tara Moreau, Arshiya Noorani, Susan K. Pell, Juan Lucas Restrepo, Erin C. Riordan, Stefan Schmitz, Paul Smith, Charles Spillane, Alvaro Toledo, Raakel Toppila, Maarten van Zonneveld, Emily Warschefsky, Peter Wenzl   +35 more
wiley   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Environmental Mycotoxins and Brain Health: Protective Role of Bromelain Against Fumonisin B1 in SH‐SY5Y Cells

Environmental Toxicology, EarlyView.
ABSTRACT Fumonisin B1 (FB1), a mycotoxin commonly found in contaminated food and feed, has been increasingly implicated in neurotoxicity, although its mechanisms remain poorly understood. This study investigates the neurotoxic potential of FB1 in human SH‐SY5Y neuroblastoma cells, both undifferentiated and RA‐differentiated, and evaluates the ...
Gianluca Antonio Franco, Francesca Inferrera, Nicla Tranchida, Davide Di Paola, Roberta Fusco, Salvatore Cuzzocrea, Enrico Gugliandolo   +6 more
wiley   +1 more source

Deconstructing Ataxia with Oculomotor Apraxia: Toward a Gene‐Based Classification and a Reappraisal of the Oculomotor Phenotype

Movement Disorders Clinical Practice, EarlyView.
Luiz Eduardo Novis, Flávio Moura Rezende Filho, Anna Maria Gomes, Victor Rebelo Procaci, Orlando Graziani Povoas Barsottini, José Luiz Pedroso   +5 more
wiley   +1 more source

Using Harvest Data to Assess Factors Influencing Regional Population Declines of Muskrats (Ondatra zibethicus) 利用捕获数据评估影响麝鼠 (Ondatra zibethicus) 区域种群数量下降的相关因素

Wildlife Letters, EarlyView.
Reported annual per‐capita harvest of muskrats (PCHM) decreased as wetland complexity (total number of wetland patches) decreased in 13 state and federal wetland areas in the Midwest, USA. Our results support the hypothesis that regional‐scale declines in the abundance of muskrats are likely associated with the losses to wetland habitats throughout the
Tim L. Hiller, Andrea Sylvia, Jesse T. Boulerice, Adam A. Ahlers, Dwayne R. Etter, Eric M. Dunton   +5 more
wiley   +1 more source

Yeast Knockout Strain Collection: Driving Functional Genomics, Biotechnological Applications and Human Disease Research

Yeast, EarlyView.
ABSTRACT The knockout strain collection of Saccharomyces cerevisiae has served as a valuable resource for functional genomics and yeast‐based biotechnology studies. A comprehensive single‐gene knockout strain collection, covering nearly all non‐essential genes, together with complementary mutant collections for essential genes, including temperature ...
Takashi Hirasawa
wiley   +1 more source

ALTERED EXPRESSION AND FUNCTIONALITY OF A2A ADENOSINE RECEPTORS IN HUNTINGTON’S DISEASE AND OTHER POLYGLUTAMINE DISORDERS [PDF]

, 2009
Several studies have suggested the possible involvement of A2A adenosine receptors in the pathogenesis of neuronal disorders, including Huntington’s disease.
Vincenzi, Fabrizio
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