Results 151 to 160 of about 57,910 (287)

A new hope for patients with Huntington's disease? [PDF]

EClinicalMedicine
eClinicalMedicine.
europepmc   +1 more source

The DNA/RNA autophagy protein SIDT2 as a novel neuropathological hallmark in Huntington disease

Brain Pathology, EarlyView.
SIDT2‐immunoreactive inclusions are observed in the striatum, cerebral cortex, and hypothalamus in HD cases with different Vonsattel grades, and the frequency of SIDT2‐immunoreactive inclusions is associated with longer CAG repeats in the huntingtin gene.
Sanaz Gabery, Sofia Bergh, Chrisovalantou Huridou, Rachel Y. Cheong, Barbara Baldo, Paul Günther Scheunemann, Marie‐Louisa Schoebel, Linda Holmquist Mengelbier, Elisabet Englund, Catriona McLean, Carsten Saft, Deniz Kirik, Maria Björkqvist, Glenda Halliday, Elisabeth Petrasch‐Parwez, Huu Phuc Nguyen, Jonasz Jeremiasz Weber, Åsa Petersén   +17 more
wiley   +1 more source

Inhibition of the NLRP3 Inflammasome With MCC950 Improves Gut Health in Huntington's Disease Mice. [PDF]

J Neurochem
Sarkar SK, Ekwudo MN, Lu D, Masson B, Kiridena P, van de Garde N, Renoir T, Vince JE, Deepagan VG, Hannan AJ, Gubert C.   +10 more
europepmc   +1 more source

Role of funders in embedding tests in conservation practice

Conservation Biology, EarlyView.
Abstract Effective conservation practice requires decisions based on reliable and relevant evidence, but significant gaps in the evidence base exist. Incorporating well‐designed tests of the effectiveness of interventions for biodiversity in conservation projects is one of the best ways to scale up the rate of evidence generation.
Rebecca K. Smith, Nancy Ockendon, Nida Al‐Fulaij, Alessandro Badalotti, Rachel Beattie, James Byrne, Sophia Cooke, Tiago de Zoeten, Winifred F. Frick, Stephan M. Funk, Douglas Gibbs, Lauren Gupta, Tatiana Hendrix, Becky Holmes, Nicola Johnstone, James Kinghorn, Simon Mickleburgh, Florence Miller, Matthew Muir, Jacob R. Owens, Danni Parks, Victoria Reilly‐Pinion, Hannah Reid, Kevin Seely, Julien Semelin, Taylor Shaw, Ruth D. Swetnam, Lisa Wheeler, William J. Sutherland   +28 more
wiley   +1 more source

Exploring huntington's disease from a neurodevelopmental perspective. [PDF]

Int J Biol Sci
Huang C, Zheng X, Li W, Zhang Z, Li S, Li XJ, Rong M, Yan S.   +7 more
europepmc   +1 more source

Clinical‐Grade Human Induced Pluripotent Stem Cell‐Derived Neural Precursor Cells Restore Motor Function and Preserve Striatal Integrity in a Quinolinic Acid‐Lesioned Rat Model of Huntington's Disease

Cell Proliferation, EarlyView.
Clinical‐grade HLA‐homozygous iPSC‐derived neural precursor cells restore motor function, rebuild striatal circuitry and reduce neuroinflammation in QA‐lesioned rats. These findings demonstrate robust neuronal replacement and microenvironment modulation, supporting their potential as a regenerative therapy for Huntington's disease.
Hyeonjoong Jeon, Il‐Shin Lee, Sanghun Lee, Hyo Chang Park, Beomsoo Kim, Hyun Sook Kim, Jihwan Song   +6 more
wiley   +1 more source

Pain processing and pain assessment in Huntington's disease: Study protocol of the Huntington's disease - PAIN study. [PDF]

PLoS One
Sprenger GP, van Velzen M, Achterberg WP, Roos RAC, de Bot ST.   +4 more
europepmc   +1 more source

Huntington Disease [PDF]

Journal of the Royal Society of Medicine, 2005
openaire   +2 more sources

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Novel Compounds for Treating Huntington's Disease. [PDF]

ACS Med Chem Lett
Sabnis RW, Sabnis AR.
europepmc   +1 more source