Results 161 to 170 of about 57,910 (287)

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

Huntington's disease clinical trials update: October 2025. [PDF]

J Huntingtons Dis
Farag M, Tabrizi SJ, Wild EJ.
europepmc   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Clinical implications of malnutrition in Huntington's disease progression: evidence from a Chinese cohort and Mendelian randomization. [PDF]

Front Nutr
Xia JQ, Cheng YF, Zhang SR, Ma YZ, Fu JJ, Yang TM, Zhang LY, Burgunder JM, Shang HF.   +8 more
europepmc   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Animal models of Huntington's disease. Pros and cons. [PDF]

Brain Behav Immun Health
Stepanova P, Voutilainen MH, Eriksson O, Lindholm D.   +3 more
europepmc   +1 more source

Exploring Theory of Mind abilities in patients with probable idiopathic normal pressure hydrocephalus

Journal of Neuropsychology, EarlyView.
Abstract This study investigated Theory of Mind (ToM) deficits in patients with suspected idiopathic normal pressure hydrocephalus (iNPH), a condition affecting motor, cognitive and autonomic functions. Given the overlap between ToM‐related neural networks and those affected in iNPH, we examined whether ToM impairments are a feature of the disease ...
Akrivi Vatsi, George Stranjalis, Stylianos Gkatzonis, Christos Koutsarnakis, Eleftherios Neromyliotis, Aristotelis Kalyvas, Ion N. Beratis, Evangelos Drosos, Spyridon Komaitis, Evangelia Liouta   +9 more
wiley   +1 more source

Executive Impairment in Huntington's Disease: Insights From a Systematic Review of the Literature. [PDF]

Brain Behav
Migliore S, Marcaccio M, Di Pompeo I, Marano M, Curcio G.   +4 more
europepmc   +1 more source

Animal fluency in people with Parkinson's disease: Item‐based performance before and after deep brain stimulation surgery

Journal of Neuropsychology, EarlyView.
Abstract People with Parkinson disease (PD) after surgery for deep brain stimulation (DBS) of the subthalamic nucleus (STN‐DBS) often decline in animal fluency due to impairments in executive functions and/or language. Item‐based measures of animal fluency may shed light on the specific nature of this decline, and into the strategies used when ...
Adrià Rofes, Nikki Janssen, Janine Rook, Eva de Ronde, R. Saman Vinke, Rianne A. J. Esselink, Annelien A. Duits   +6 more
wiley   +1 more source

Decreased Physical Activity as an Early Digital Biomarker in Huntington's Disease: A One-Year Observational Study. [PDF]

Brain Behav
Simón-Vicente L, Calvo S, Mariscal N, Muñoz-Siscart I, Diaz-Piñeiro D, Rivadeneyra J, Cubo E.   +6 more
europepmc   +1 more source