Results 141 to 150 of about 57,910 (287)
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi +12 more
wiley +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Fumonisin B1 (FB1), a mycotoxin commonly found in contaminated food and feed, has been increasingly implicated in neurotoxicity, although its mechanisms remain poorly understood. This study investigates the neurotoxic potential of FB1 in human SH‐SY5Y neuroblastoma cells, both undifferentiated and RA‐differentiated, and evaluates the ...
Gianluca Antonio Franco +6 more
wiley +1 more source
Advances in cholesterol and lipoproteins detection for healthcare: A review
VIEW, EarlyView.Cholesterol is one of the main biomarkers related to the development of cardiovascular diseases. Its detection still relies on traditional methods of analysis, such as gas and liquid chromatographies. Detection of free cholesterol in saliva with redox or enzymatic sensors or detection of lipoproteins in blood with aptamer sensors are currently the most
Jacopo Giaretta +7 more
wiley +1 more source
‘I, Me, Myself’: Selfhood and Melancholy in the Journals of Gertrude Savile (1697–1758)
Journal for Eighteenth-Century Studies, EarlyView.Abstract This article examines the journals of Gertrude Savile from 1727 in light of recent scholarship on early modern and eighteenth‐century melancholy. The concept had myriad associations with medicine, physiology, the imagination, and feeling, but questions remain about how melancholy during this period was considered by those outside the narrow ...
Daniel Beaumont
wiley +1 more source
Indigenous‐Led Adaptation to Complex Climate Risks in New Ireland, Papua New Guinea
Asia Pacific Viewpoint, EarlyView.ABSTRACT Pacific Island peoples have long histories of adapting to environmental changes, but recent climate change is now driving complex risks that unfold within rapidly shifting societal and environmental contexts. This study investigates how remote Indigenous communities in New Ireland, Papua New Guinea, experience and want to respond to complex ...
Eric Lede +3 more
wiley +1 more source
Laypeople's Views on the Narrative Identity and Societal Treatment of Genetically Modified People
Bioethics, EarlyView.ABSTRACT Genome editing in human embryos could raise new ethical issues by changing future people's narrative and numerical identity. Most philosophers agree that some genetic modifications would have larger effects on identity than others, but they disagree on what criteria might explain these differences and have not supported their claims ...
Derek So, Yann Joly, Robert Sladek
wiley +1 more source
Huntington's Disease and Huntington's Disease-like 2 (HDL2) in Martinique. [PDF]
Mov Disord Clin PractAntolin-Sanfeliz I +8 more
europepmc +1 more source
Information Discrimination and Its Implications on Distributing Healthcare Costs Fairly
Bioethics, EarlyView.ABSTRACT When healthcare resources are scarce, they ought to be distributed fairly across society. For some theories of distribution, an assessment of individual health risk is required for a fair distribution of both healthcare resources and burdens. Despite this requirement, prevailing theories underappreciate the cost of information on health risk ...
Harisan U. Nasir
wiley +1 more source
Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice
Brain Pathology, EarlyView.We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga +11 more
wiley +1 more source