Results 141 to 150 of about 4,891,805 (263)

The Timely Rise of a Teenage Reformer: Youth Revolt, Feminism and the Struggle for a ‘New Sexual Morality’ at the Dawn of the Spanish Second Republic

Gender &History, EarlyView.
ABSTRACT The contributions of propagandist and writer Hildegart (1914–1933) to Spanish cultural life are overshadowed by accounts of her unusual upbringing and violent death. This article examines the conditions that enabled the teenager to become a prominent voice for feminism and sexual reform on the eve of Spain's Second Republic (1931–1939).
Micaela Pattison
wiley   +1 more source

The role of glia in protein misfolding diseases

, 2010
The astrocytes, oligodendrocytes and microglia make up a significant proportion of the cells of the CNS. In recent years, there has been a burgeoning interest in the role of glial cells, in neurodegenerative disease.
Samson, Ben
core   +1 more source

Corrigendum to “Increased central microglial activation associated with peripheral cytokine levels in premanifest Huntington's disease gene carriers” [Neurobiol. Dis. 83 (2015) 115–121]

Neurobiology of Disease, 2017
Marios Politis, Nayana Lahiri, Flavia Niccolini, Paul Su, Kit Wu, Paolo Giannetti, Rachael I. Scahill, Federico E. Turkheimer, Sarah J. Tabrizi, Paola Piccini   +9 more
doaj   +1 more source

Rethinking diabetic retinopathy: Homeostatic mechanisms for retinal clearance

Diabetic Medicine, EarlyView.
In the healthy retina, balanced production and clearance of metabolic waste and fluid maintain retinal homeostasis and normal visual function. Diabetes disrupts this balance, increasing the accumulation of metabolic waste products, including advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs), while impairing waste and ...
Karis Little, Judith Lechner, Giulia De Rossi, Tara Cullen, Jennifer Perais, Eleni Beli, Noemi Lois, Alan W. Stitt   +7 more
wiley   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

In vivo evidence for NMDA receptor mediated excitotoxicity in a murine genetic model of Huntington Disease [PDF]

, 2008
N-methyl-D-aspartate receptor (NMDAR) mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disease (HD). However, this hypothesis has not been tested rigorously in vivo. NMDAR NR2B-subunits are the predominant NR2
Joe Tsien, Roger Albin, Mary Heng, Phillip Wang, Peter Detloff   +4 more
core  

Responding With Evidence and Access for Childhood Headaches (REACH) study: A comparative effectiveness trial of cognitive behavioral therapy monotherapy versus combined cognitive behavioral therapy–pharmacotherapy with amitriptyline for the prevention of childhood migraine—The study protocol

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Migraine is one of the most common chronic health problems in children and adolescents, resulting in high levels of functional disability. Symptoms frequently persist into and impact the course of adulthood for affected individuals. Current practice recommendations include a combined therapy approach of preventive medication and cognitive ...
Estée C. H. Feldman, Michelle M. Ernst, Maya A. Marzouk, Robert C. Gibler, Brooke L. Reidy, Leigh A. Chamberlin, Megan Kirschman, James Peugh, Marielle Kabbouche, Susan L. LeCates, Joanne Kacperski, Jessica A. Saunders, Andrew D. Hershey, Marcy E. Yonker, Christina L. Szperka, Amy A. Gelfand, Scott W. Powers, on behalf of the REACH Study Investigators, Joanne Kacperski, Jennifer McVige, Frank Berenson, Chaouki Khoury, Judy Adelizzi‐Delany, Marcy Yonker, Elizabeth Ackley, J. Ivan Lopez, Ann Pakalnis, Sara Pavitt, Scott Turner, Elizabeth Doll, Michael Sowell, Rachel Evans, Lauren Evanczyk, Reena Rastogi, Amy Gelfand, Hannah Shapiro, Christina Szperka, Ankita Gosh, Rashmi Rao   +38 more
wiley   +1 more source

Huntington Disease [PDF]

Journal of the Royal Society of Medicine, 2005
openaire   +2 more sources

Association of BCAAs/BCKAs with pancreatic steatosis in patients with type 2 diabetes mellitus: A cross‐sectional study

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims To examine the association between branched‐chain α‐keto acids (BCKAs) and pancreatic steatosis in patients with type 2 diabetes (T2DM). Methods This cross‐sectional study was conducted from January 2023 to March 2025. Upper abdominal computerized tomography was performed, pancreatic volume (PV), PV index (PVI), CT attenuation of pancreas
Jie Gao, Pijun Cheng, Fusong Jiang, Wenmin Li, Yingying Shi, Wenjun Wang, Liang Wang, Tao Lei, Yunxiang Zang, Jun Lu   +9 more
wiley   +1 more source

20th Anniversary of human‐induced pluripotent stem cells and the role of microscopy

Journal of Microscopy, EarlyView.
Abstract It has been 20 years since the pioneering work of Shinya Yamanaka and Kazutoshi Takahashi at Kyoto University led to the first successful generation of induced pluripotent stem cells (iPSCs) from mouse embryonic and adult fibroblast cells. iPSCs have the capacity to differentiate into any type of cell in the human body, and as such, they have ...
Philomena Hallford, Colette J. Mustard, Nicole Brace, Antonia L. Pritchard   +3 more
wiley   +1 more source