Results 291 to 299 of about 49,474 (299)
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Huntingtin facilitates selective autophagy
Nature Cell Biology, 2015Selective autophagy is essential for maintaining cellular homeostasis under different growth conditions. Huntingtin, mutated versions of which have been implicated in Huntington disease, is now shown to act as a scaffold protein that couples the induction of autophagy and the selective recruitment of cargo into autophagosomes.
Zvulun Elazar +2 more
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Science, 2001
Huntington9s disease (HD) is a neurodegenerative disease caused by an expanded run of glutamine repeats in the huntingtin protein. How this glutamine expansion results in the selective loss of striatal neurons characteristic of HD is not known. In a Perspective, Trottier and Mandel discuss new findings demonstrating that loss of the beneficial ...
Yvon Trottier, Jean-Louis Mandel
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Huntington9s disease (HD) is a neurodegenerative disease caused by an expanded run of glutamine repeats in the huntingtin protein. How this glutamine expansion results in the selective loss of striatal neurons characteristic of HD is not known. In a Perspective, Trottier and Mandel discuss new findings demonstrating that loss of the beneficial ...
Yvon Trottier, Jean-Louis Mandel
openaire +2 more sources
Huntingtin's critical cleavage
Nature Neuroscience, 2006The early pathogenic events leading to neurodegeneration in Huntington disease are not clear. A recent paper shows that mutating a caspase-6 cleavage site in the huntingtin protein is sufficient to prevent pathogenesis.
Huda Y. Zoghbi, John D. Fryer
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Discovery of Small Molecules that Induce the Degradation of Huntingtin.
Angewandte Chemie, 2017Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by the aggregation of mutant huntingtin (mHtt), and removal of toxic mHtt is expected to be an effective therapeutic approach.
Shusuke Tomoshige +4 more
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Hunting for the effects of huntingtin
Science, 2014Neurodegeneration Huntington's disease (HD) is associated with a mutant form of the protein huntingtin (Htt). HD-associated symptoms are alleviated by inhibition of the kinase mTOR, which activates protein synthesis when amino acids are plentiful. In mouse striatal neurons, Pryor et al.
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Huntington Disease and the Huntingtin Protein
2012Huntington disease (HD) is a devastating neurodegenerative disease that derives from CAG repeat expansion in the huntingtin gene. The clinical syndrome consists of progressive personality changes, movement disorder, and dementia and can develop in children and adults.
Zhiqiang Zheng, Marc I. Diamond
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Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease
Science, 2001C. Zuccato +12 more
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