Results 221 to 230 of about 5,553,804 (280)

The biology and expression of huntingtin interacting protein 14

, 2011
Huntingtin Interacting Protein 14 (HIP14) is a palmitoyl acyl transferase (PAT) that was first identified due to altered interaction with mutant huntingtin, the protein responsible for Huntington Disease. HIP14 palmitoylates a specific set of neuronal substrates critical at the synapse, and downregulation of HIP14 by siRNA in vitro results in increased
openaire   +2 more sources

A method for the analysis of the oligomerization profile of the Huntington's disease-associated, aggregation-prone mutant huntingtin protein by isopycnic ultracentrifugation. [PDF]

Front Mol Biosci
Bonavita R, Di Martino R, Cortone G, Prodomo A, Di Gennaro M, Scerra G, Panico V, Nuzzo S, Salvatore M, Williams SV, Vitale F, Caporaso MG, D'Agostino M, Pisani FM, Fleming A, Renna M.   +15 more
europepmc   +1 more source

Nucleation Inhibition of Huntingtin Protein (htt) by Polyproline PPII Helices: A Potential Interaction with the N-Terminal α-Helical Region of Htt. [PDF]

Biochemistry, 2020
Arndt JR, Chaibva M, Beasley M, Kiani Karanji A, Ghassabi Kondalaji S, Khakinejad M, Sarver O, Legleiter J, Valentine SJ.   +8 more
europepmc   +1 more source

Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex

Human Molecular Genetics, 2016
Tamara Maiuri, Andrew J. Mocle, C. L. Hung, Jianrun Xia, W. V. van Roon-Mom, R. Truant   +5 more
semanticscholar   +1 more source

Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS-STING-dependent apoptosis. [PDF]

Proc Natl Acad Sci U S A
Sun X, Liu L, Wu C, Li X, Guo J, Zhang J, Guan J, Wang N, Gu L, Yang XW, Li GM.   +10 more
europepmc   +1 more source

Interaction with Polyglutamine-expanded Huntingtin Alters Cellular Distribution and RNA Processing of Huntingtin Yeast Two-hybrid Protein A (HYPA) [PDF]

, 2011
Yajun Jiang, Meixia Che, Jin-Qiao Yuan, Yuan-Yuan Xie, Xian-Zhong Yan, Hong-Yu Hu   +5 more
openalex   +1 more source

Aggregation landscapes of Huntingtin exon 1 protein fragments and the critical repeat length for the onset of Huntington’s disease

Proceedings of the National Academy of Sciences of the United States of America, 2017
Mingchen Chen, P. Wolynes
semanticscholar   +1 more source

High Levels of Mutant Huntingtin Protein in Tear Fluid From Huntington's Disease Gene Expansion Carriers. [PDF]

J Mov Disord
Gijs M, Jorna N, Datson N, Beekman C, Dansokho C, Weiss A, Linden DEJ, Oosterloo M.   +7 more
europepmc   +1 more source

SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation

Cell Reports, 2013
J. O’Rourke, Jaclyn R. Gareau, Joseph Ochaba, Wan-Geun Song, T. Rasko, D. Reverter, John S. Lee, A. M. Monteys, J. Pallos, Lisa Mee, Malini Vashishtha, B. Apostol, T. P. Nicholson, K. Illes, Ya-zhen Zhu, M. Dasso, G. Bates, M. Difiglia, B. Davidson, E. Wanker, J. Marsh, C. Lima, J. Steffan, L. Thompson   +23 more
semanticscholar   +1 more source

Dithiol-based Compounds Maintain Expression of Antioxidant Protein Peroxiredoxin 1 That Counteracts Toxicity of Mutant Huntingtin [PDF]

, 2012
Andrea Pitts, Kyle M Dailey, Jordan T. Newington, Andrew Chien, Robert Arseneault, Tyler Cann, Leslie M. Thompson, Robert C. Cumming   +7 more
openalex   +1 more source