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Huperzine A: a natural acetylcholinesterase inhibitor with multifunctional neuroprotective effects

Beni-Suef University Journal of Basic and Applied Sciences
Background Huperzine A, a naturally derived compound, has garnered interest for its capacity to inhibit cholinesterase with multifaceted neuroprotective effects and is obtained from Huperzia serrata (Chinese club moss plant).
Suvaiv, Kuldeep Singh, Syed Misbahul Hasan, Arun Kumar, Abdullah Khan, Mo. Shahanawaz, Syed Mehdi, Hasan Zaidi, Kausal Verma   +8 more
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Huperzine A injection ameliorates motor and cognitive abnormalities via regulating multiple pathways in a murine model of Parkinson's disease.

European Journal of Pharmacology, 2023
As a common progressive neurodegenerative disorder, the satisfied therapies for Parkinson's disease (PD) are still unavailable. As a natural acetylcholinesterase inhibitor, the neuroprotective characteristic of Huperzine A (HupA) was supported by ...
Xinran Guo, Yuhan Wu, Qingqing Wang, Jianbing Zhang, Xueping Sheng, Lanrong Zheng, Yule Wang   +6 more
semanticscholar   +1 more source

Divergent Total Synthesis of the Lycopodium Alkaloids Huperzine A, Huperzine B, and Huperzine U

The Journal of Organic Chemistry, 2013
Huperzine A, huperzine B, and huperzine U are congeners isolated from the Chinese herb Huperzia serrata (= Lycopodium serratum ) in minuscule amounts. The most efficient total synthesis of huperzine A, the first asymmetric total syntheses of huperzine B, and the first total synthesis of huperzine U have been achieved efficiently in overall yields of 17%
Rui, Ding, Jian-Guo, Fu, Guang-Qiang, Xu, Bing-Feng, Sun, Guo-Qiang, Lin   +4 more
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Inhibition of microtubule affinity regulating kinase 4 by an acetylcholinesterase inhibitor, Huperzine A: Computational and experimental approaches.

International Journal of Biological Macromolecules, 2023
Microtubule affinity regulating kinase 4 (MARK4), 752 amino acids long, belonging to the AMPK superfamily, plays a vital role in regulating microtubules due to its potential to phosphorylate microtubule-associated proteins (MAP's). Thus MARK4 plays a key
Mohammed Alrouji, Debarati DasGupta, Ghulam Md. Ashraf, A. L. Bilgrami, F. Alhumaydhi, Waleed Al Abdulmonem, M. Shahwan, Abdulrhman Alsayari, A. Atiya, Anas Shamsi   +9 more
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Network pharmacology and biochemical experiments reveal the antiapoptotic mechanism of huperzine A for treating diabetic retinopathy

British Journal of Ophthalmology, 2023
Background/aims Diabetic retinopathy is the most common eye disease that causes blindness in the working population. Neurodegeneration is the early sign of diabetic retinopathy, but no drug has been approved for delaying or reversing retinal ...
Ying Zhang, Wunan Huang, Qing Tian, Guannan Bai, Wei Wu, H. Yin, Lidan Hu, Xiangjun Chen   +7 more
semanticscholar   +1 more source

Huperzine A for Alzheimer's disease

Internal Medicine News, 2006
Alzheimer's disease (AD) has become a major public health problem around the world due to its increasing prevalence, long duration, caregiver burden, and high financial cost of care. The degeneration of acetylcholine-containing neurons in the basal forebrain has been implicated in the symptoms of AD.
J, Li, H M, Wu, R L, Zhou, G J, Liu, B R, Dong   +4 more
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Study of Huperzine A derivatives with extended protection against soman intoxication.

Toxicology and Applied Pharmacology, 2023
Pre-administration of huperzine A (Hup A) was validated to prevent poisoning from exposure to nerve agents (NAs) by reversibly inhibiting acetylcholinesterase (AChE). However, like the currently commonly used reversible inhibitors, Hup A has a short half-
Yalan Cui, Xuejun Chen, Jingjing Shi, Qian Jin, Ruihua Zhang, T. Shi, Chen Wang, Liqin Li   +7 more
semanticscholar   +1 more source

Delineating biosynthesis of Huperzine A, A plant-derived medicine for the treatment of Alzheimer's disease.

Biotechnology Advances, 2022
Huperzine A (HupA) is a plant-derived lycopodium alkaloid used for the treatment of Alzheimer's disease due to its inhibition against acetylcholinesterase.
Xiao Li, Wei Li, P. Tian, T. Tan
semanticscholar   +1 more source

Total Synthesis of (−)-Huperzine A

Organic Letters, 2009
The total synthesis of huperzine Q was accomplished. The synthesis features the construction of the cis-hydrindane skeleton via a Diels-Alder reaction and a ring contraction reaction of an epoxyketone.
Toshimune Nomura, Satoshi Yokoshima, Tohru Fukuyama   +2 more
openaire   +4 more sources

Ginkgolides and Huperzine A for complementary treatment of Alzheimer's disease

IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2022
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by gradual deterioration of cognitive function, memory, and inability to perform daily, social, or occupational activities.
Cecilia Villegas, Rebeca Pérez, L. Petiz, T. Glaser, H. Ulrich, Cristian Paz   +5 more
semanticscholar   +1 more source