Results 151 to 160 of about 2,786 (199)
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Synthesis of (±)-desamino huperzine A
Tetrahedron Letters, 2000The first synthesis of desamino huperzine A 2 is described. Key steps are a double Michael addition into benzoquinone monoketal 4, a regiocontrolled double bond isomerisation and a novel pyridone synthesis involving a Michael addition of a ß-keto ester into acrylonitrile. (C) 2000 Elsevier Science Ltd.
Högenauer, Klemens +2 more
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A total synthesis of (±)-huperzine A
Tetrahedron Letters, 1989Abstract The first total synthesis of (±)-huperzine A, a new lycopodium alkaloid is described.
Ligang Qian, Ruyun Ji
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Huperzia javanica as a Novel Source of Huperzine Alkaloids and Huperzine-producing Fungi
Indian Journal of MicrobiologyHuperzine A (HupA) and huperzine B (HupB) are potent acetylcholinesterase inhibitor used widely for clinical treatment of Alzheimer's disease, which are mainly extracrted from natural populations of Huperzia species. This study aimed to the evaluate potential of producing Hup of native Huperzia javanica species collected in Vietnam as well as identify ...
Thanh Thi Minh, Le +6 more
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A Formal Synthesis of (+)-Huperzine A
Tetrahedron, 2000Abstract A new formal stereoselective synthesis of (+)-Huperzine A (1) was achieved using as a key step a palladium mediated annulation between 2-methylene-1,3-propanediol diacetate and (1R,2S)-2-phenylcyclohexanol derived β-ketoester 2c.
Arnaud Haudrechy +3 more
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Chemico-Biological Interactions, 2013
The neuropathologic mechanisms after exposure to lethal doses of nerve agent are complex and involve multiple biochemical pathways. Effective treatment requires drugs that can simultaneously protect by reversible binding to the acetylcholinesterase (AChE) and blocking cascades of seizure related brain damage, inflammation, neuronal degeneration as well
Ying, Wang +4 more
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The neuropathologic mechanisms after exposure to lethal doses of nerve agent are complex and involve multiple biochemical pathways. Effective treatment requires drugs that can simultaneously protect by reversible binding to the acetylcholinesterase (AChE) and blocking cascades of seizure related brain damage, inflammation, neuronal degeneration as well
Ying, Wang +4 more
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Role of Huperzine a in the Treatment of Alzheimer's Disease
Annals of Pharmacotherapy, 2009Objective: To review the role of huperzine A in the treatment of Alzheimer's disease (AD). Data Sources: A literature search was conducted through MEDLINE (1950–September week 2, 2008), EMBASE (all years), Google Scholar, International
Alicia R, Desilets +2 more
exaly +3 more sources
Biotechnological approaches for the production of neuroactive huperzine A
Journal of BiotechnologyHuperzine A (HupA), a natural Lycopodium alkaloid primarily derived from Huperzia serrata, has gained attention for its potent neuroprotective properties, particularly its ability to inhibit acetylcholinesterase and modulate key neurological pathways.
Mubeen Fatima +3 more
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