Results 1 to 10 of about 1,730 (122)

Huperzine A and Huperzine B Production by Prothallus Cultures of Huperzia selago (L.) Bernh. ex Schrank et Mart [PDF]

Molecules, 2020
This is the first report of an efficient and effective procedure to optimize the biosynthesis of huperzine A (HupA) and huperzine B (HupB) in vitro from Huperzia selago gametophytes. Axenic tissue cultures were established using spores collected from the
Wojciech J. Szypuła, Beata Wileńska, Aleksandra Misicka, Agnieszka Pietrosiuk   +3 more
doaj   +6 more sources

Synthetic approaches towards huperzine A and B [PDF]

ARKIVOC, 2013
Huperzine A and B are potent acetylcholinesterase inhibitors and promising against Alzheimer's disease. Completed and formal total syntheses of these medically relevant alkaloids are presented and discussed.
Shariar Md. Abu Sohel, Till Opatz
doaj   +2 more sources

Lysine and cadaverine differentially regulate huperzine biosynthesis in axenic gametophyte cultures of Huperzia selago (L.) Bernh. ex Schrank et Mart. [PDF]

BMC Plant Biology
Background Specialized metabolites represent a major component of plant adaptive and chemical diversity and constitute an important source of pharmacologically relevant compounds.
Wojciech J. Szypuła, Michał Markowski, Beata Wileńska   +2 more
doaj   +2 more sources

Neuroprotective Effects of Huperzine B and Huperzia carinata Extract Against MPP+-Induced Oxidative Stress in SH-SY5Y Cells [PDF]

Advances in Pharmacological and Pharmaceutical Sciences
Parkinson’s disease (PD) is a neurodegenerative disorder associated with dopaminergic neuronal loss, mitochondrial dysfunction, and redox imbalance.
Kittikun Viwatpinyo, Poommaree Namchaiw, Pipob Suwanchaikasem, Sujira Mukda, Sudichhya Tamrakar, Amit Jaisi, Sakan Warinhomhoun   +6 more
doaj   +2 more sources

Huperzine A Production and Acetylcholinesterase Inhibition by Phlegmariurus taxifolius Cell Suspension Culture: A Comparative Study in Flasks and an Airlift Bioreactor [PDF]

Pharmaceuticals
Background: The callus cultures from the fronds of the lycophyte Phlegmariurus taxifolius produce the huperzine A (HupA) alkaloid, which is used in Alzheimer’s disease treatment.
Rocío del Carmen Pérez Aguilar, Talia Rodríguez Salgado, Olga Lidia Cruz-Miranda, Alexis Uriel Soto Díaz, Ariadna Zenil Rodríguez, Lamine Bensaddek, Christian Carreño-Campos, María Luisa Villarreal, Anabel Ortiz-Caltempa, Alexandre Toshirrico Cardoso-Taketa   +9 more
doaj   +2 more sources

Exploring the molecular mechanisms of huperzine a in the treatment of rosacea through network pharmacology, machine learning, and molecular dynamics simulations [PDF]

Frontiers in Pharmacology
IntroductionRosacea is a common chronic inflammatory skin disorder and dysregulation of neuroimmune functions and neurovascular loops play critical roles in the development of rosacea.
Xin Luo, Suhan Yang, Lian Zhong, Peng Zhang   +3 more
doaj   +2 more sources

Novel 16-substituted bifunctional derivatives of huperzine B: multifunctional cholinesterase inhibitors. [PDF]

Acta Pharmacol Sin, 2009
To design novel bifunctional derivatives of huperzine B (HupB) based on the concept of dual binding site of acetylcholinesterase (AChE) and evaluate their pharmacological activities for seeking new drug candidates against Alzheimer's disease (AD).Novel 16-substituted bifunctional derivatives of HupB were synthesized through chemical reactions.
Shi YF, Zhang HY, Wang W, Fu Y, Xia Y, Tang XC, Bai DL, He XC.   +7 more
europepmc   +4 more sources

Harmine and 7,8-dihydroxyflavone synergistically suitable for amyotrophic lateral sclerosis management: An in silico study [PDF]

Research Results in Pharmacology, 2022
Introduction: Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease characterized by progressive degeneration of both upper and lower motor neurons, resulting in paralysis and eventually leads to death from respiratory failure typically ...
Toluwase Fatoki, Stanley Chukwuejim, Omodele Ibraheem, Christiana Oke, Blessing Ejimadu, Isaiah Olaoye, Oluwabukola Oyegbenro, Taiwo Salami, Romilola Basorun, Oluwafisayomi Oluwadare, Yetunde Salawudeen   +10 more
doaj   +3 more sources

Neuroprotective Effect of Huperzine A on -Galactose-Induced Hearing Dysfunction

Ear, Nose & Throat Journal, 2021
Background: Administration of d -galactose ( d -gal) has been used to create animal models of neurodegenerative diseases, and huperzine A has been used to treat the neurodegenerative diseases such as Alzheimer disease. Methods: An animal model of hearing
Cong Li MM, Song Shi MD
doaj   +1 more source

Isolation and Characterization of Novel Huperzine-Producing Endophytic Fungi from Lycopodiaceae Species

Journal of Fungi, 2023
Huperzine A (HupA) is an important drug for treating Alzheimer’s disease (AD) and is primarily extracted from the Huperzia serrata (Lycopodiaceae). Failures in the chemical synthesis of Hup and in vitro culture have put H. serrata in danger of extinction,
Thanh Thi Minh Le, Ha Thanh Pham, Ha Thi Thu Trinh, Hoa Thi Tran, Ha Hoang Chu   +4 more
doaj   +1 more source