Results 41 to 50 of about 12,358,109 (167)

Huperzine A reverses scopolamine- and muscimol-induced memory deficits in chick

, 2000
AIM: To study the effects of huperzine A on disruption of spatial memory induced by scopolamine (a muscarinic antagonist) and muscimol (a GABA(A) agonist) in passive avoidance task.
Tang, XC, Gao, Y, Guan, LC, Kuang, PZ
core   +2 more sources

Neuronutraceuticals for Alzheimer's Disease Treatment: A Systematic Review of Randomised Controlled Trials Over the Last 20 Years

Phytochemicals in Food and Medicine, Volume 1, Issue 1, March 2026.
This PROSPERO‐registered review analysed 37 RCTs on neuronutraceuticals for Alzheimer's disease. Despite diverse targets—amyloid/tau, inflammation, oxidative stress, metabolism, synaptic plasticity, cholinergic and hormonal—the evidence was of low quality. RoB2 flagged attrition (86.5%) and reporting bias (81%). Current data do not support clinical use;
Mehmet Akif Topcuoglu, Esen Saka
wiley   +1 more source

Rapid Structural Analysis of Natural Products Using MicroED

Small, Volume 22, Issue 15, 12 March 2026.
The cryoEM method, MicroED used for rapid analysis and structure determination of natural products that remained unattainable by other structural biology methods ABSTRACT Structural analysis of natural products remains challenging due to their inherent complexity and limited availability.
Jieye Lin, Orel Paz, Johan Unge, Tamir Gonen   +3 more
wiley   +1 more source

Exposure the Hazardous Potential of Quinalphos: An In‐Depth Analysis for Environmental and Biological Effects on Human Health

IET Systems Biology, Volume 20, Issue 1, January/December 2026.
This study elucidates pesticide docking onto proteins encoded by differentially expressed genes, revealing interaction networks involving chemicals, genes, proteins, drugs and diseases. It highlights structural insights, regulatory pathways and potential therapeutic or environmental implications, providing a comprehensive understanding of the ...
Jyoti Kant Choudhari, Biju Prava Sahariah, Anand Kumar Jayapal, Jyotsna Choubey, Abhishek Tripathi   +4 more
wiley   +1 more source

Synthetic approaches to huperzine A

, 1994
The natural product huperzine A has been found to possess activity as a nootropic agent. Because of its memory facilitating effects, huperzine A represents a promising drug for the treatment of neurodegenerative diseases, such as Alzheimer's disease.
Vines, Danette
core   +1 more source

Total Synthesis of Huperzine Q [PDF]

, 2017
The total synthesis of huperzine Q was accomplished. The synthesis features the construction of the cis-hydrindane skeleton via a Diels–Alder reaction and a ring contraction reaction of an epoxyketone.journal ...
Satoshi Yokoshima, Fukuyama, Tohru, Shun Tanimura, Tohru Fukuyama, Yokoshima, Satoshi, Tanimura, Shun   +5 more
core   +1 more source

Hesperidin, Hesperetin, and Naringenin in Retinal Pathophysiology: Molecular Crosstalk Between Metabolic Dysfunction, Neuroinflammation, and Therapeutic Signaling in Diabetic Retinopathy

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Diabetic retinopathy (DR) is a leading cause of blindness worldwide, characterized by retinal vascular dysfunction, oxidative stress, inflammation, and neuronal degeneration. Flavonoids such as hesperidin (HSD), hesperetin (HST), and naringenin, commonly found in citrus fruits, have shown promise in mitigating DR through multiple molecular mechanisms ...
Guangling Feng, Zhicheng Huang, Farzam Kiarasi   +2 more
wiley   +1 more source

From Demyelination to Intervention: Natural Compounds as Emerging Therapeutic Targets in Multiple Sclerosis Neuroinflammation

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Multiple sclerosis (MS) is a chronic immune‐mediated inflammatory demyelinating disease of the central nervous system (CNS), characterized by multifocal lesions, axonal damage, and progressive neurological dysfunction, imposing a heavy burden on patients and healthcare systems.
Zhiyong Long, Qianyue Yang, Yonghe Wu, Lifei Wan, Liuting Zeng, Lingyun Sun, Poorani Gurumallesh   +6 more
wiley   +1 more source

Comparative efficacy of pharmacotherapy and non‐pharmacotherapy for treating Alzheimer's disease: A systematic review and network meta‐analysis for cognitive, behavior and functional outcomes

Alzheimer's &Dementia, Volume 21, Issue S4, December 2025.
Abstract Importance Alzheimer's disease (AD), the most prevalent form of dementia, contributes significantly to global disability. Pharmacotherapies (PTs) often have adverse effects, while diverse non‐pharmacotherapies (NPTs) lack comprehensive comparative evaluations against PTs.
Chitima Boongird, Worapong Tearneukit, Wannisa Wongpipathpong, Unyaporn Suthutvoravut, Masatha Thongpan, Natthakorn Pongsettakul, Gareth J McKay, Sasivimol Rattanasiri, Thunyarat Anothaisintawee, Ammarin Thakkinstian   +9 more
wiley   +1 more source

Asymmetric Total Synthesis and Structure Elucidation of Huperzine H

, 2022
A first asymmetric total synthesis of huperzine H has been achieved in a 12% overall yield from commercially available (+)-pulegone. The key steps of this synthesis include a highly diastereoselective Mukaiyama–Michael addition reaction of a pyrrole ...
Kaewsri Wilailak, Shinya Shiomi (2087134), Mariko Kitajima (1743181), Mariko Kitajima, Shinya Shiomi, Wataru Soutome, Hiromitsu Takayama, Hiromitsu Takayama (1743178), Hayato Ishikawa, Kaewsri Wilailak (11959453), Wataru Soutome (11959456), Hayato Ishikawa (2134999)   +11 more
core   +1 more source