Evaluation of acetylcholinesterase and butyrylcholinesterase inhibitory activity of Huperzine-A; in silico and in vitro studies [PDF]
, 2019 The present study is focused on exploring the Acetylcholinesterase and Butyrylcholinesterase inhibitory activity of Huperzine-A in silico and in vitro. In this study, Huperzine-A-A was docked with Acetylcholinesterase and Butyrylcholinesterase.
Kohli, Seema +3 more
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Huperzine A ameliorated oligomeric Aβ42 induced damage in primary rat neurons.
, 2015 A. The results of MTT assay (N = 6). B. The results of SRB assay (N = 3). Data were presented as percentage of control group, and shown as mean ± SEM. ***p < 0.001 vs control group; #p < 0.05, ###p < 0.001 vs oligomeric Aβ42-treated group.
Hai Yan Zhang (589189) +7 more
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Qualification and quantification of huperzine a from Huperia serrata in Da Lat, Lam Dong province
, 2016 Huperzine A, an alkaloid, was originally isolated from Huperzia serrata. This compound potentially enhances the memory in animal, hence, it has been approved as a drug for the clinical treatment of Alzheimer’s disease, a major disease affecting the ...
Nguyễn Tiến Đạt +4 more
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Structural analogs of huperzine A improve survival in guinea pigs exposed to soman
, 2013 Chemical warfare nerve agents such as soman exert their toxic effects through an irreversible inhibition of acetylcholinesterase (AChE) and subsequently glutamatergic function, leading to uncontrolled seizures.
Hendra Gunosewoyo (1648369) +6 more
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Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors
, 1999 Hybrid acetylcholinesterase inhibitors composed of a key fragment of huperzine A and an intact tacrine unit were prepared. The syntheses are quite direct, proceeding in a maximum of 4 linear steps from commercially available starting materials.
Han, Yifan +4 more
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Doença de Alzheimer e Huperzine Huperzine A for Alzheimer's disease Synopsis
, 2020 There is currently insufficient evidence of the effects of Huperzine A for Alzheimer's disease (AD). Huperzine A is derived from Chinese club moss Huperzia serrata, and is described as having several properties which may be beneficial for AD.
J Li, Dong Br, Liu Gj, Wu Hm, Zhou Rl
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Synthesis of 7-desmethyl analogs of (+)- and (-)-huperzine A
, 2015 The natural alkaloid (-)-huperzine A is an inhibitor of AChE and has been demonstrated to exert neuroprotection and to possess beneficial effects on other CNS related disorders. In this manuscript, we report the synthesis of the analogs of huperzine A in
PIERONI, Marco, Tipparaju, Suresh K.
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Australasian Huperzia as potential sources of Huperzine alkaloids
, 2010 © 2010 Wei-Han LimThe Lycopodiaceae is an ancient and cosmopolitan family of fern allies that include an estimated 35 Huperzia species occurring throughout the South-East Asian and Australian region.
Lim, Wei-Han
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Self-Emulsifying Formulation of <i>Huperzia carinata</i> Extract to Improve Huperzine A Solubility for Therapeutic Efficacy Enhancement in Parkinsonian Mice. [PDF]
ACS OmegaSermkaew N +8 more
europepmc +1 more source
The Clinical Analysis of Combined Effects of Huperzine A and Memantine for Alzheimer’s Disease
The purpose of this study was to evaluate the clinical effects of a combination of Huperzine A and memantine for the treatment of Alzheimer’s disease (AD).
Maolong Gao, Shouzi Zhang, Qinyun Li
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