Results 1 to 10 of about 1,873 (124)

Natural Chiral Scaffolds in Alzheimer's Disease: Therapeutic Potential, Mechanism, and Clinical Aspects. [PDF]

Biomed Res Int
Alzheimer′s disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive cognitive impairment, amyloid‐β deposition, tau pathology, oxidative stress, neuroinflammation, and dysfunction of synapses. Current therapeutic options are largely symptomatic and lack disease‐modifying efficacy.
Singh A, Sahu SK, Sah AK.
europepmc   +2 more sources

Comparative efficacy of pharmacotherapy and non‐pharmacotherapy for treating Alzheimer's disease: A systematic review and network meta‐analysis for cognitive, behavior and functional outcomes [PDF]

Alzheimers Dement
Abstract Importance Alzheimer's disease (AD), the most prevalent form of dementia, contributes significantly to global disability. Pharmacotherapies (PTs) often have adverse effects, while diverse non‐pharmacotherapies (NPTs) lack comprehensive comparative evaluations against PTs.
Boongird C, Tearneukit W, Wongpipathpong W, Suthutvoravut U, Thongpan M, Pongsettakul N, McKay G, Rattanasiri S, Anothaisintawee T, Thakkinstian A.   +9 more
europepmc   +2 more sources

Extended release huperzine for the treatment of idiopathic epilepsy in dogs – a Case Report [PDF]

Frontiers in Veterinary Science
Huperzine is a naturally occurring alkaloid derived from the Chinese clubmoss Huperzia serrata. It is a potent acetylcholinesterase inhibitor, among other properties, and has demonstrated protection against induced seizures in a mouse model of Dravet’s ...
Kylie L. Grant, Sam N. Long
doaj   +2 more sources

Huperzine A suppresses absence seizures in the genetic absence epilepsy rat from Strasbourg (GAERS) model of genetic generalized epilepsy with absence seizures [PDF]

Epilepsia Open
Objective We evaluated huperzine A treatment in the Genetic Absence Epilepsy Rat from Strasbourg (GAERS) model of genetic generalized epilepsy (GGE) with absence seizures.
Pablo M. Casillas‐Espinosa, Jennie Garcia‐Olivares, Rui Li, Crystal Li, Chungping Yu, Andrea E. Formella, Terence J. O'Brien   +6 more
doaj   +2 more sources

Huperzine A improves neurological function in mice with intracerebral hemorrhage by alleviating neuroinflammation and ferroptosis [PDF]

Scientific Reports
Intracerebral hemorrhage (ICH) is a devastating neurological condition that is characterized by high morbidity and long-term disability, which frequently results in severe neurological deficits.
Shanjun Wang, Shuangyan Li, Xinguo Sun, Yunzhao Chen, Ruiyun Yan, Yuheng Liu, Zengguang Wang   +6 more
doaj   +2 more sources

Huperzine A ameliorates neurological deficits after spontaneous subarachnoid hemorrhage through endothelial cell pyroptosis inhibition [PDF]

Acta Biochimica et Biophysica Sinica
Spontaneous subarachnoid hemorrhage (SAH) is a kind of hemorrhagic stroke which causes neurological deficits in survivors. Huperzine A has a neuroprotective effect, but its role in SAH is unclear.
Hu Qiang, Zhang Rong, Dong Xiaoqiao, Yang Dingbo, Yu Wenhua, Du Quan   +5 more
doaj   +2 more sources

Return to Spontaneous Circulation in a Patient With Cholinergic Syndrome at the Emergency Department of Buea Regional Hospital, Cameroon. [PDF]

Clin Case Rep
ABSTRACT With the increasing misuse of herbal treatment and pesticides, cases of cholinergic syndrome following herbal treatment or organophosphate poisoning have become increasingly common in our milieu. However, when advanced, mortality is high. We report the successful management of a case involving a 54‐year‐old African female with a known history ...
Nteungue BBK, Nyuydzefon B, Kouomogne BAN, Siysi VV.   +3 more
europepmc   +2 more sources

Antioxidant, Anti-Inflammatory, and Chemical Composition Analysis of In Vitro Huperzia serrata Thallus and Wild Huperzia serrata [PDF]

Molecules
Huperzine A is a preferred treatment option for Alzheimer’s disease. Huperzia serrata (Thunb. ex Murray) Trev. (H. serrata) has garnered significant attention for its ability to produce Huperzine A (HupA). However, natural populations of wild H. serrata (
Yongchun Huang, Xinyuan Li, Liangfang Dai, Malong Cheng, Linlin Zhao, Yu Shen, Jiankun Xie, Xiangdong Luo   +7 more
doaj   +2 more sources

Co-cultivation Serratia marcescens with Trichoderma harzianum for improving production of Huperzine A [PDF]

Applied Microbiology and Biotechnology
Plant-derived (−)-Huperzine A (HupA), the bioactive enantiomer of the acetylcholinesterase inhibitor used for Alzheimer’s disease (AD) therapy, is limited by the scarcity of Huperzia serrata (HS), while chemically synthesized (+)-HupA is clinically ...
Han Wen-Xia, Han Zhong-Wen, Mi Yu, Zhang Han, Li Wei-Ze, Guan Li, Zhang Ning, Wang Lin, Jia Min, Mei Shan-Shan   +9 more
doaj   +2 more sources

Phyllosphere mycobiome in two Lycopodiaceae plant species: unraveling potential HupA-producing fungi and fungal interactions [PDF]

Frontiers in Plant Science
Huperzine A (HupA), a lycopodium alkaloid with therapeutic potential for neurodegenerative diseases such as Alzheimer’s disease, is found exclusively in some species of the Huperzioideae subfamily of Lycopodiaceae.
Liqun Lin, Cheng Li, Chiung-Chih Chang, Ran Du, Jiaojiao Ji, Li-Yaung Kuo, Ko-Hsuan Chen   +6 more
doaj   +2 more sources