Results 11 to 20 of about 114,626,959 (164)

The pharmacology and therapeutic potential of (-)-huperzine A

Journal of Experimental Pharmacology, 2012
Maung Kyaw Moe Tun, Seth B HerzonDepartment of Chemistry, Yale University, New Haven, CT, USAAbstract: (–)-Huperzine A (1) is an alkaloid isolated from a Chinese club moss.
Herzon SB, Tun MK
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Total Synthesis of Huperzine Q [PDF]

Organic Letters, 2017
The total synthesis of huperzine Q was accomplished. The synthesis features the construction of the cis-hydrindane skeleton via a Diels–Alder reaction and a ring contraction reaction of an epoxyketone.journal ...
Satoshi Yokoshima, Fukuyama, Tohru, Shun Tanimura, Tohru Fukuyama, Yokoshima, Satoshi, Tanimura, Shun   +5 more
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Synthetic approaches to huperzine A

, 1994
The natural product huperzine A has been found to possess activity as a nootropic agent. Because of its memory facilitating effects, huperzine A represents a promising drug for the treatment of neurodegenerative diseases, such as Alzheimer's disease.
Vines, Danette
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Divergent Total Synthesis of the Lycopodium Alkaloids Huperzine A, Huperzine B, and Huperzine U

, 2016
Huperzine A, huperzine B, and huperzine U are congeners isolated from the Chinese herb Huperzia serrata (=Lycopodium serratum) in minuscule amounts. The most efficient total synthesis of huperzine A, the first asymmetric total syntheses of huperzine B ...
Bing-Feng Sun (1863463), Guo-Qiang Lin (1589989), Guang-Qiang Xu (1863460), Rui Ding (423236), Jian-Guo Fu (1863457)   +4 more
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Valorization of Ficus carica Pruning Residues as Selective Botanical Insecticides: Optimized Furanocoumarin Extraction, Efficacy Against Neotropical Stink Bugs, and Mechanistic Insights via Molecular Docking. [PDF]

Arch Insect Biochem Physiol
Optimized extracts from Ficus carica pruning waste exhibit strong biological activity against major stink bug pests. Complementary in silico analyses suggest this efficacy relies on pest‐specific acetylcholinesterase inhibition, predicting a promising, pollinator‐safe alternative for sustainable agriculture.
Almeida TA, Páez AR, Costa LTM, Smagghe G, Cardoso YM, Faria LM, Oliveira EE, Leite JPV.   +7 more
europepmc   +2 more sources

Natural Chiral Scaffolds in Alzheimer's Disease: Therapeutic Potential, Mechanism, and Clinical Aspects. [PDF]

Biomed Res Int
Alzheimer′s disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive cognitive impairment, amyloid‐β deposition, tau pathology, oxidative stress, neuroinflammation, and dysfunction of synapses. Current therapeutic options are largely symptomatic and lack disease‐modifying efficacy.
Singh A, Sahu SK, Sah AK.
europepmc   +2 more sources

Huperzine A for vascular dementia [PDF]

Cochrane Database of Systematic Reviews, 2008
Huperzine A, a form of herbal medicine, has been considered as an alternative treatment for vascular dementia (VaD) in China.To assess the efficacy and safety of Huperzine A in patients with vascular dementia.The Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (CDCIG) was searched on 7 July 2008 using the terms: huperzi ...
Zilong, Hao, Ming, Liu, Zhiqin, Liu, Donghao, Lv   +3 more
openaire   +2 more sources

Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine−Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's Disease [PDF]

, 1999
Eleven new 12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline derivatives [tacrine (THA)−huperzine A hybrids, rac-21−31] have been synthesized as racemic mixtures and tested as acetylcholinesterase (AChE) inhibitors.
Badia, Albert, Vivas, Nuria María, Orozco, Modesto, Morral-Cardoner, Jordi, Barril, Xavier, Görbig, Diana Marina, Baños, Josep Eladi, Camps, Pelayo, Muñoz-Torrero, Diego, El Achab, Rachid, Luque, Francisco Javier, Xavier Barril, Francisco Javier Luque, Nuria María Vivas, Pelayo Camps, Jordi Morral, Modesto Orozco, Diana Marina Görbig, Albert Badia, Rachid El Achab, Josep Eladi Baños, Diego Muñoz-Torrero   +21 more
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New Tacrine−Huperzine A Hybrids (Huprines): Highly Potent Tight-Binding Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease [PDF]

, 2000
Several new 12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline derivatives (tacrine−huperzine A hybrids, huprines) have been synthesized and tested as acetylcholinesterase (AChE) inhibitors.
Badia, Albert, Vivas, Nuria María, Orozco, Modesto, Morral-Cardoner, Jordi, Barril, Xavier, Baños, Josep Eladi, Camps, Pelayo, Muñoz-Torrero, Diego, El Achab, Rachid, Luque, Francisco Javier   +9 more
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Huperzine A for mild cognitive impairment [PDF]

Cochrane Database of Systematic Reviews, 2010
Mild cognitive impairment (MCI) has been proposed as a condition of intermediate symptomatology between the cognitive changes of ageing and fully developed symptoms of dementia. Treatment in the stages of MCI may delay the deterioration of cognitive impairment and delay the progression to dementia. Currently, the treatments for Alzheimer's disease have
Jirong, Yue, Bi Rong, Dong, Xiufang, Lin, Ming, Yang, Hong Mei, Wu, Taixiang, Wu   +5 more
openaire   +2 more sources