Rapid Structural Analysis of Natural Products Using MicroED. [PDF]
SmallThe cryoEM method, MicroED used for rapid analysis and structure determination of natural products that remained unattainable by other structural biology methods ABSTRACT Structural analysis of natural products remains challenging due to their inherent complexity and limited availability.
Lin J, Paz O, Unge J, Gonen T.
europepmc +2 more sources
Loss of Pathogenicity and Evidence of Horizontal Gene Transfer in Colletotrichum gloeosporioides From a Medicinal Plant. [PDF]
Mol Plant PatholA Colletotrichum gloeosporioides strain from Huperzia serrata lacks key pathogenicity genes CgDN3 and cap20 and has fewer pelB, pnl and pg genes. pksIII, for synthesis of huperzine A, was probably acquired by the host plant from the fungus. ABSTRACT Colletotrichum gloeosporioides is a major agricultural pathogen of crops that has also been identified ...
Yue X +17 more
europepmc +2 more sources
Exploring the molecular mechanisms of huperzine a in the treatment of rosacea through network pharmacology, machine learning, and molecular dynamics simulations [PDF]
Frontiers in PharmacologyIntroductionRosacea is a common chronic inflammatory skin disorder and dysregulation of neuroimmune functions and neurovascular loops play critical roles in the development of rosacea.
Xin Luo +3 more
doaj +2 more sources
Systematic Investigations of the Huperzine A—Producing Endophytic Fungi of Huperzia serrata in China and Fermentation Optimization Using OSMAC Strategy [PDF]
MoleculesHuperzine A (HupA) can alleviate Alzheimer’s disease due to its reversible inhibition of acetylcholinesterase (AChE). The chemical synthesis and plant extraction of HupA is plagued by route complexity and resource scarcity, respectively.
Wei Li +3 more
doaj +2 more sources
Biosynthesis of plant neuroactive alkaloids treating Alzheimer’s disease [PDF]
Frontiers in PharmacologyQuanyu Yin, Zhengkang Zhu, Mengquan Yang
doaj +2 more sources
Huperzine A protects against traumatic brain injury through anti-oxidative effects via the Nrf2-ARE pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Traumatic brain injury (TBI) is a prominent health problem worldwide and it may lead to cognitive dysfunction, disability, and even death. To date, there is no effective treatment for TBI.
Zhengrong Mei +4 more
doaj +1 more source
De novo RNA sequencing and transcriptome analysis of Colletotrichum gloeosporioides ES026 reveal genes related to biosynthesis of huperzine A. [PDF]
PLoS ONE, 2015 Huperzine A is important in the treatment of Alzheimer's disease. There are major challenges for the mass production of huperzine A from plants due to the limited number of huperzine-A-producing plants, as well as the low content of huperzine A in these ...
Guowei Zhang +10 more
doaj +1 more source
Pharmaceutical Biology, 2023 Context Alkaloid-enriched extract of Huperzia serrata (Thunb.) Trevis (Lycopodiaceae) (HsAE) can potentially be used to manage neuronal disorders.Objective This study determines the anti-neuroinflammatory effects of HsAE on lipopolysaccharide (LPS ...
Thu Kim Dang +8 more
doaj +1 more source
Integration of System Biology Tools to Investigate Huperzine A as an Anti-Alzheimer Agent
Frontiers in Pharmacology, 2021 Aim: The present study aimed to investigate huperzine A as an anti-Alzheimer agent based on the principle that a single compound can regulate multiple proteins and associated pathways, using system biology tools.Methodology: The simplified molecular ...
Pukar Khanal +12 more
doaj +1 more source
Involvement of Intracellular and Mitochondrial Aβ in the Ameliorative Effects of Huperzine A against Oligomeric Aβ42-Induced Injury in Primary Rat Neurons. [PDF]
PLoS ONE, 2015 Considerable studies indicate huperzine A is a promising natural product to suppress neuronal damages induced by β-amyloid (Aβ), a key pathogenic event in the Alzheimer's disease (AD).
Yun Lei +7 more
doaj +1 more source