De novo RNA sequencing and transcriptome analysis of Colletotrichum gloeosporioides ES026 reveal genes related to biosynthesis of huperzine A. [PDF]
PLoS ONE, 2015 Huperzine A is important in the treatment of Alzheimer's disease. There are major challenges for the mass production of huperzine A from plants due to the limited number of huperzine-A-producing plants, as well as the low content of huperzine A in these ...
Guowei Zhang +10 more
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Lysine and cadaverine differentially regulate huperzine biosynthesis in axenic gametophyte cultures of Huperzia selago (L.) Bernh. ex Schrank et Mart. [PDF]
BMC Plant BiologyBackground Specialized metabolites represent a major component of plant adaptive and chemical diversity and constitute an important source of pharmacologically relevant compounds.
Wojciech J. Szypuła +2 more
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Extended release huperzine for the treatment of idiopathic epilepsy in dogs – a Case Report [PDF]
Frontiers in Veterinary ScienceHuperzine is a naturally occurring alkaloid derived from the Chinese clubmoss Huperzia serrata. It is a potent acetylcholinesterase inhibitor, among other properties, and has demonstrated protection against induced seizures in a mouse model of Dravet’s ...
Kylie L. Grant, Sam N. Long
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Huperzine A suppresses absence seizures in the genetic absence epilepsy rat from Strasbourg (GAERS) model of genetic generalized epilepsy with absence seizures [PDF]
Epilepsia OpenObjective We evaluated huperzine A treatment in the Genetic Absence Epilepsy Rat from Strasbourg (GAERS) model of genetic generalized epilepsy (GGE) with absence seizures.
Pablo M. Casillas‐Espinosa +6 more
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Antioxidant, Anti-Inflammatory, and Chemical Composition Analysis of In Vitro Huperzia serrata Thallus and Wild Huperzia serrata [PDF]
MoleculesHuperzine A is a preferred treatment option for Alzheimer’s disease. Huperzia serrata (Thunb. ex Murray) Trev. (H. serrata) has garnered significant attention for its ability to produce Huperzine A (HupA). However, natural populations of wild H. serrata (
Yongchun Huang +7 more
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Metabolomic Analysis of Goji Berry Sun-Drying: Dynamic Changes in Small-Molecule Substances [PDF]
FoodsGoji berries (Lycium barbarum L.) are valued for their nutritional and medicinal properties; however, the systematic biochemical impact of drying on their quality remains poorly understood.
Yao Zhang +6 more
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Huperzine A improves neurological function in mice with intracerebral hemorrhage by alleviating neuroinflammation and ferroptosis [PDF]
Scientific ReportsIntracerebral hemorrhage (ICH) is a devastating neurological condition that is characterized by high morbidity and long-term disability, which frequently results in severe neurological deficits.
Shanjun Wang +6 more
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Integration of System Biology Tools to Investigate Huperzine A as an Anti-Alzheimer Agent
Frontiers in Pharmacology, 2021 Aim: The present study aimed to investigate huperzine A as an anti-Alzheimer agent based on the principle that a single compound can regulate multiple proteins and associated pathways, using system biology tools.Methodology: The simplified molecular ...
Pukar Khanal +12 more
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Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
Molecules, 2021 Huperzine A (HupA), an alkaloid found in the club moss Huperzia serrata, has been used for centuries in Chinese folk medicine to treat dementia.
María Jesús Friedli +1 more
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Involvement of Intracellular and Mitochondrial Aβ in the Ameliorative Effects of Huperzine A against Oligomeric Aβ42-Induced Injury in Primary Rat Neurons. [PDF]
PLoS ONE, 2015 Considerable studies indicate huperzine A is a promising natural product to suppress neuronal damages induced by β-amyloid (Aβ), a key pathogenic event in the Alzheimer's disease (AD).
Yun Lei +7 more
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