Extended release huperzine for the treatment of idiopathic epilepsy in dogs – a Case Report [PDF]
Frontiers in Veterinary ScienceHuperzine is a naturally occurring alkaloid derived from the Chinese clubmoss Huperzia serrata. It is a potent acetylcholinesterase inhibitor, among other properties, and has demonstrated protection against induced seizures in a mouse model of Dravet’s ...
Kylie L. Grant, Sam N. Long
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The pharmacology and therapeutic potential of (-)-huperzine A
Journal of Experimental Pharmacology, 2012 Maung Kyaw Moe Tun, Seth B HerzonDepartment of Chemistry, Yale University, New Haven, CT, USAAbstract: (–)-Huperzine A (1) is an alkaloid isolated from a Chinese club moss.
Tun MK, Herzon SB
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Huperzine A suppresses absence seizures in the genetic absence epilepsy rat from Strasbourg (GAERS) model of genetic generalized epilepsy with absence seizures [PDF]
Epilepsia OpenObjective We evaluated huperzine A treatment in the Genetic Absence Epilepsy Rat from Strasbourg (GAERS) model of genetic generalized epilepsy (GGE) with absence seizures.
Pablo M. Casillas‐Espinosa +6 more
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Huperzine A ameliorates neurological deficits after spontaneous subarachnoid hemorrhage through endothelial cell pyroptosis inhibition [PDF]
Acta Biochimica et Biophysica SinicaSpontaneous subarachnoid hemorrhage (SAH) is a kind of hemorrhagic stroke which causes neurological deficits in survivors. Huperzine A has a neuroprotective effect, but its role in SAH is unclear.
Hu Qiang +5 more
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Examining the interactome of huperzine A by magnetic biopanning. [PDF]
PLoS ONE, 2012 Huperzine A is a bioactive compound derived from traditional Chinese medicine plant Qian Ceng Ta (Huperzia serrata), and was found to have multiple neuroprotective effects.
Wei Guo +8 more
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Antioxidant, Anti-Inflammatory, and Chemical Composition Analysis of In Vitro Huperzia serrata Thallus and Wild Huperzia serrata [PDF]
MoleculesHuperzine A is a preferred treatment option for Alzheimer’s disease. Huperzia serrata (Thunb. ex Murray) Trev. (H. serrata) has garnered significant attention for its ability to produce Huperzine A (HupA). However, natural populations of wild H. serrata (
Yongchun Huang +7 more
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Isolation and purification of Huperzine A
浙江大学学报. 农业与生命科学版, 2002 Technique of isolation and purification of Huperzine A from Huperzia serrata (Thunb) Trev. was studied in this paper. To get rid of some pigments and other impurities, some of chemical techniques for separation such as extraction with organic acid ...
SHEN Sheng-rong +3 more
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Metabolomic Analysis of Goji Berry Sun-Drying: Dynamic Changes in Small-Molecule Substances [PDF]
FoodsGoji berries (Lycium barbarum L.) are valued for their nutritional and medicinal properties; however, the systematic biochemical impact of drying on their quality remains poorly understood.
Yao Zhang +6 more
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Huperzine A improves neurological function in mice with intracerebral hemorrhage by alleviating neuroinflammation and ferroptosis [PDF]
Scientific ReportsIntracerebral hemorrhage (ICH) is a devastating neurological condition that is characterized by high morbidity and long-term disability, which frequently results in severe neurological deficits.
Shanjun Wang +6 more
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Co-cultivation Serratia marcescens with Trichoderma harzianum for improving production of Huperzine A [PDF]
Applied Microbiology and BiotechnologyPlant-derived (−)-Huperzine A (HupA), the bioactive enantiomer of the acetylcholinesterase inhibitor used for Alzheimer’s disease (AD) therapy, is limited by the scarcity of Huperzia serrata (HS), while chemically synthesized (+)-HupA is clinically ...
Han Wen-Xia +9 more
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