Results 31 to 40 of about 2,786 (199)

Anti-neuroinflammatory effects of alkaloid-enriched extract from Huperzia serrata on lipopolysaccharide-stimulated BV-2 microglial cells

Pharmaceutical Biology, 2023
Context Alkaloid-enriched extract of Huperzia serrata (Thunb.) Trevis (Lycopodiaceae) (HsAE) can potentially be used to manage neuronal disorders.Objective This study determines the anti-neuroinflammatory effects of HsAE on lipopolysaccharide (LPS ...
Thu Kim Dang, Seong-Min Hong, Vui Thi Dao, Phuong Thi Thu Tran, Hiep Tuan Tran, Giang Hoang Do, Thanh Nguyen Hai, Hang Thi Nguyet Pham, Sun Yeou Kim   +8 more
doaj   +1 more source

Data on the drug release profiles and powder characteristics of the ethyl cellulose based microparticles prepared by the ultra-fine particle processing system

Data in Brief, 2020
Ethyl cellulose (EC) based microparticles (MPs) could provide sustained release for Huperzine A. The drug release mechanism of MPs was exploited to achieve an ideal drug release profile. We previously found that the wettability of MPs greatly contributed
Tingting Peng, Yin Shi, Chune Zhu, Disang Feng, Xiangyu Ma, Peipei Yang, Xuequn Bai, Xin Pan, Chuan-yu Wu, Wen Tan, Chuanbin Wu   +10 more
doaj   +1 more source

Isolation and Characterization of Novel Huperzine-Producing Endophytic Fungi from Lycopodiaceae Species

Journal of Fungi, 2023
Huperzine A (HupA) is an important drug for treating Alzheimer’s disease (AD) and is primarily extracted from the Huperzia serrata (Lycopodiaceae). Failures in the chemical synthesis of Hup and in vitro culture have put H. serrata in danger of extinction,
Thanh Thi Minh Le, Ha Thanh Pham, Ha Thi Thu Trinh, Hoa Thi Tran, Ha Hoang Chu   +4 more
doaj   +1 more source

Comparative efficacy of pharmacotherapy and non‐pharmacotherapy for treating Alzheimer's disease: A systematic review and network meta‐analysis for cognitive, behavior and functional outcomes [PDF]

Alzheimers Dement
Abstract Importance Alzheimer's disease (AD), the most prevalent form of dementia, contributes significantly to global disability. Pharmacotherapies (PTs) often have adverse effects, while diverse non‐pharmacotherapies (NPTs) lack comprehensive comparative evaluations against PTs.
Boongird C, Tearneukit W, Wongpipathpong W, Suthutvoravut U, Thongpan M, Pongsettakul N, McKay G, Rattanasiri S, Anothaisintawee T, Thakkinstian A.   +9 more
europepmc   +2 more sources

Huperzine A for mild cognitive impairment [PDF]

Cochrane Database of Systematic Reviews, 2010
Mild cognitive impairment (MCI) has been proposed as a condition of intermediate symptomatology between the cognitive changes of ageing and fully developed symptoms of dementia. Treatment in the stages of MCI may delay the deterioration of cognitive impairment and delay the progression to dementia. Currently, the treatments for Alzheimer's disease have
Jirong, Yue, Bi Rong, Dong, Xiufang, Lin, Ming, Yang, Hong Mei, Wu, Taixiang, Wu   +5 more
openaire   +2 more sources

Detection by UPLC/ESI-TOF-MS of Alkaloids in Three Lycopodiaceae Species from French Polynesia and Their Anticholinesterase Activity

Natural Product Communications, 2009
Three Lycopodiaceae species from French Polynesia, Lycopodium venustulum C. Gaudichaud, Lycopodiella cernua (C. Linnaeus) R. E. Pichi Sermolli and Lycopodium henryanum E. D.
Raimana Ho, Niloufar Marsousi, Philippe Eugster, Jean-Pierre Bianchini, Phila Raharivelomanana   +4 more
doaj   +1 more source

In Silico Design of Dual-Binding Site Anti-Cholinesterase Phytochemical Heterodimers as Treatment Options for Alzheimer’s Disease

Current Issues in Molecular Biology, 2021
The number of patients with neurodegenerative diseases, particularly Alzheimer’s disease (AD), continues to grow yearly. Cholinesterase inhibitors (ChEIs) represent the first-line symptomatic drug treatment for mild-to-moderate AD; however, there is an ...
Hafsa Amat-ur-Rasool, Mehboob Ahmed, Shahida Hasnain, Abrar Ahmed, Wayne Grant Carter   +4 more
doaj   +1 more source

Huperzine A ameliorates neurological deficits after spontaneous subarachnoid hemorrhage through endothelial cell pyroptosis inhibition

Acta Biochimica et Biophysica Sinica
Spontaneous subarachnoid hemorrhage (SAH) is a kind of hemorrhagic stroke which causes neurological deficits in survivors. Huperzine A has a neuroprotective effect, but its role in SAH is unclear.
Hu Qiang, Zhang Rong, Dong Xiaoqiao, Yang Dingbo, Yu Wenhua, Du Quan   +5 more
doaj   +1 more source

Lycodine-Type Alkaloids from Lycopodiastrum casuarinoides and Their Acetylcholinesterase Inhibitory Activity

Molecules, 2014
Four new lycodine-type alkaloids, namely 16-hydroxyhuperzine B (1), N-methyl-11-acetoxyhuperzine B (2), 8,15-dihydrolycoparin A (3) and (7S,12S,13R)-huperzine D-16-O-β-d-glucopyranoside (4), along with ten known analogues 5−14, were isolated from the ...
Dong-Bo Zhang, Jian-Jun Chen, Qiu-Yan Song, Li Zhang, Kun Gao   +4 more
doaj   +1 more source

Huperzine A in SCI [PDF]

Science-Business eXchange, 2013
Harvard Medical School researchers have shown that the plant-derived small molecule huperzine A can reduce neuropathic pain in rats with spinal cord injury. Insero Health has licensed IP covering epilepsy and neuropathic pain and plans to report Phase Ib data this year in treatment-resistant epilepsy.
openaire   +1 more source