Results 41 to 50 of about 2,786 (199)

Huperzine A

Drugs in R & D, 2004
Huperzine A, an alkaloid isolated from Huperzia serrata, is a putative nootropic agent developed by the Chinese Academy of Sciences. Huperzine A is currently in phase III trials in China for the treatment of patients with Alzheimer's disease. The mechanism of action of huperzine A is suggested to be facilitated through the slow reversible inhibition of
openaire   +2 more sources

Anti-Cholinesterase Activity of Lycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis

Molecules, 2014
A series of Lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8α-hydrophlemariurine B (5), and huperzinine (6), has been isolated from Vietnamese Huperzia squarrosa.
Nguyen Ngoc Chuong, Nguyen Thi Thu Huong, Tran Manh Hung, Tran Cong Luan   +3 more
doaj   +1 more source

Bis-huperzine B:  Highly Potent and Selective Acetylcholinesterase Inhibitors

, 2016
By targeting dual active sites of AChE, a series of bis-huperzine B analogues with various lengths of the tether were designed, synthesized, and tested for their inhibition and selectivity.
Hualiang Jiang (19452), Zhifei Wang (1622731), Song Feng (1639162), Xuchang He (2693506), Suxin Zheng (2338309), Xican Tang (2693509), Yu Xia (8822), Donglu Bai (2693512)   +7 more
core   +2 more sources

Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy

Phytotherapy Research, EarlyView.
This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi, LuLu Zhang, Lan Yan, Qi Geng, Li Li, Xiaojuan He, Ning Zhao, Yong Tan, Xiaomeng Zhang, Cheng Lu   +9 more
wiley   +1 more source

A drug screening toolkit based on the –1 ribosomal frameshifting of SARS-CoV-2

Heliyon, 2020
The –1 ribosomal frameshifting is vital for the translation of the open reading frame (ORF)1b in SARS-CoV-2. The products of ORF1b participate in viral replication. Therefore, changing the frameshift frequency reduces the survival of the virus.
Yanqiong Chen, Huan Tao, Silan Shen, Zhiyong Miao, Lili Li, Yongqian Jia, Hu Zhang, Xiufeng Bai, Xinyuan Fu   +8 more
doaj   +1 more source

Research Trends and Mechanistic Insights Into Natural Medicines for Alzheimer's Disease: A Bibliometric Analysis and Narrative Review

Phytotherapy Research, EarlyView.
Research landscape and mechanistic insights into natural medicines for Alzheimer's disease. ABSTRACT Natural medicines have been widely investigated for Alzheimer's disease (AD), but the development of this field and the relationship between bibliometric themes and experimental evidence remain insufficiently characterized.
Maoning Wang, Xiaolian Zhang, Huaxian Yang, Jianhe Zhao, Wentao Wei, Qian Zhao, Wenjia Wang, Yunhui Hu, Jiansong Fang   +8 more
wiley   +1 more source

Development of methods for synthesis of the huperzine alkaloids

, 2000
The primary goal of this project is to explore the synthesis of huperzine alkaloids via the photoinitiated intramolecular ylide alkene cylcloaddition. Huperzine A and B are both potent inhibitors of acetylcholinesterase, the enzyme responsible for the ...
Contonio, Brooke Diane
core   +3 more sources

Salvianolic Acid B Inhibits Ferroptosis in Acute Lung Injury: Network Analysis and Experimental Validation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT This current study aimed to decipher the anti‐inflammatory, anti‐ferroptosis and pronounced lung‐protective activities of Salvianolic acid B (Sal B) by integrating network pharmacology and experimental confirmation across multiple aspects. The optimal target protein and the relevant molecular mechanisms for Sal B in the context of ALI were ...
Hejun Gao, Renhui Xiong, Na Yue, Jiaxin Wang, Shouyuan Tian   +4 more
wiley   +1 more source

Evaluation of Huperzine A Concentration-dependent Antimicrobial and Antibiofilm Activity against Streptococcus mutans and Candida glabrata: An In-vitro Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Antimicrobial Resistance (AMR) is a growing global public health crisis, with biofilm-forming microorganisms demonstrating significantly enhanced resistance to conventional antimicrobial agents. Biofilm-associated infections are notoriously
M Tejas, S Ramya, Nidarsan Viswanathan , Kavitha Ramasamy   +3 more
doaj   +1 more source

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, Volume 13, Issue 47, 24 August 2026.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source