Results 61 to 70 of about 1,924 (168)
The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases
MedComm, Volume 6, Issue 6, June 2025.Τhe BBB restricts CNS drug delivery. NBDD bypasses the BBB via olfactory/trigeminal routes, enabling CNS delivery of therapeutic (small molecules, biologics, nucleic acids) for neurodegenerative/psychiatric disorders and brain tumors using advanced NBDD delivery systems (e.g nanocarriers) to enhance targeting and bioavailability.
Yi Qiu +7 more
wiley +1 more source
Huperzine A: a natural acetylcholinesterase inhibitor with multifunctional neuroprotective effects
Beni-Suef University Journal of Basic and Applied SciencesBackground Huperzine A, a naturally derived compound, has garnered interest for its capacity to inhibit cholinesterase with multifaceted neuroprotective effects and is obtained from Huperzia serrata (Chinese club moss plant).
Suvaiv +7 more
doaj +1 more source
Donepezil increases resistance to induced seizures in a mouse model of Dravet syndrome
Annals of Clinical and Translational Neurology, 2019 De novo loss‐of‐function mutations in SCN1A are the main cause of Dravet syndrome, a catastrophic encephalopathy characterized by recurrent early‐life febrile seizures, a number of other afebrile seizure types that are often refractory to treatment, and ...
Jennifer C. Wong +2 more
doaj +1 more source
Natural Product Communications, 2009 The alkaloid cryptolepine (1) and eight synthetic analogues (2-8) were assessed for in vitro activities against Trypanosoma brucei . Four of the analogues were found to be highly potent with IC 50 values of less than 3 nM and three of these were assessed
Awotunde J. Oluwafemi +7 more
doaj +1 more source
Drug Delivery, 2020 Increasingly attention has been paid to the transdermal drug delivery systems with microneedles owing to their excellent compliance, high efficiency, and controllable drug release, therefore, become promising alternative with tremendous advantages for ...
Qinying Yan +9 more
doaj +1 more source
Frontiers in PharmacologyBackgroundVascular dementia (VaD) is one of the most prevalent, burdensome, and costly forms of dementia. Pharmacological treatment is often the first-line choice for clinicians; however, there is a paucity of comparative information regarding the ...
Chun Dang +6 more
doaj +1 more source
Huperzine A: is it an effective disease-modifying drug for Alzheimer’s disease?
Frontiers in Aging Neuroscience, 2014 Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which there is no cure. Huperzine A (HupA) is a natural inhibitor of acetylcholinesterase (AChE) derived from the Chinese folk medicine Huperzia serrata (Qian Ceng Ta).
Zhong Ming eQian, Ya eKe
doaj +1 more source
Frontiers in Plant ScienceIntroductionCrop rotation of tobacco with other crops could effectively break the negative impact of continuous tobacco cropping, but the mechanisms of intercropping system effects on tobacco, especially on the rhizosphere, are not clear.MethodsIn this ...
Ming Liu +9 more
doaj +1 more source
Development of 2-Methoxyhuprine as Novel Lead for Alzheimer’s Disease Therapy
Molecules, 2017 Tacrine (THA), the first clinically effective acetylcholinesterase (AChE) inhibitor and the first approved drug for the treatment of Alzheimer’s disease (AD), was withdrawn from the market due to its side effects, particularly its hepatotoxicity ...
Eva Mezeiova +16 more
doaj +1 more source