Results 51 to 60 of about 2,786 (199)

Potential of Naturally Derived Alkaloids as Multi-Targeted Therapeutic Agents for Neurodegenerative Diseases

open access: yesMolecules, 2021
Alkaloids are a class of secondary metabolites that can be derived from plants, fungi and marine sponges. They are widely known as a continuous source of medicine for the management of chronic disease including cancer, diabetes and neurodegenerative ...
Yew Rong Kong   +5 more
doaj   +1 more source

Rapid HPLC-ESI-MS/MS Analysis of Neurotransmitters in the Brain Tissue of Alzheimer’s Disease Rats before and after Oral Administration of Xanthoceras sorbifolia Bunge

open access: yesMolecules, 2018
In order to explore the potential therapeutic effect of Xanthoceras sorbifolia Bunge. against Alzheimer’s disease, an HPLC-MS/MS method has been developed and validated for simultaneous determination in rat brain of eight neurotransmitters ...
Zheng Sun, Qing Li, Kaishun Bi
doaj   +1 more source

Microtubules in Spinal Cord Injury: From Cytoskeletal Dysregulation to Therapeutic Regeneration

open access: yesJournal of Neurochemistry, Volume 170, Issue 8, August 2026.
Graphical illustration of the microtubule interactome following spinal cord injury as potential targets for therapy. ABSTRACT Spinal cord injury (SCI) triggers an immediate and sustained disruption of the composition and organization of the neuronal cytoskeleton.
Itzhak Fischer, Peter W. Baas
wiley   +1 more source

In vivo Volumetric, DTI and 1H MRS Rat Brain Protocol for Monitoring Early Neurodegeneration and Efficacy of the Used Therapy

open access: yesMeasurement Science Review, 2023
The aim of our study was to develop a multimodal experimental protocol for in vivo imaging and metabolic parameters (MRI, DTI and 1H MRS) in an animal model of neurodegeneration. We have successfully developed the protocol for simultaneous DTI/MRI/1H MRS
Tvrdík Tomáš   +6 more
doaj   +1 more source

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

open access: yesFood Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du   +7 more
wiley   +1 more source

Asymmetric Total Synthesis and Structure Elucidation of Huperzine H

open access: yes, 2022
A first asymmetric total synthesis of huperzine H has been achieved in a 12% overall yield from commercially available (+)-pulegone. The key steps of this synthesis include a highly diastereoselective Mukaiyama–Michael addition reaction of a pyrrole ...
Kaewsri Wilailak   +11 more
core   +1 more source

Huperzine A reverses scopolamine- and muscimol-induced memory deficits in chick

open access: yes, 2000
AIM: To study the effects of huperzine A on disruption of spatial memory induced by scopolamine (a muscarinic antagonist) and muscimol (a GABA(A) agonist) in passive avoidance task.
Tang, XC, Gao, Y, Guan, LC, Kuang, PZ
core   +2 more sources

The Cholinesterase Inhibitory Properties of Stephaniae Tetrandrae Radix

open access: yesMolecules, 2020
Stephaniae tetrandrae radix (STR) is a commonly used traditional Chinese medicine in alleviating edema by inducing diuresis. In the clinic, STR extracts or its components are widely used in the treatment of edema, dysuria, and rheumatism for the ...
Xiang-Peng Kong   +7 more
doaj   +1 more source

The Role of Nootropic Supplements in Sports: Enhancing Cognitive and Physical Performance Simultaneously

open access: yesFood Science &Nutrition, Volume 14, Issue 5, May 2026.
The review examines the nootropic effects of substances used in sports through their impact on neurotransmission, neuroendocrine control, energy production, synaptic plasticity, and neurovascular connections. The four key neurotransmitters dopamine, acetylcholine, serotonin, and GABA function to control motivation, attention, fatigue perception, and ...
Zheng Yi
wiley   +1 more source

Exploring Linalool‐Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition

open access: yesPhytotherapy Research, Volume 40, Issue 5, Page 2604-2631, May 2026.
Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli   +4 more
wiley   +1 more source

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