Results 51 to 60 of about 1,924 (168)

From Demyelination to Intervention: Natural Compounds as Emerging Therapeutic Targets in Multiple Sclerosis Neuroinflammation

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Multiple sclerosis (MS) is a chronic immune‐mediated inflammatory demyelinating disease of the central nervous system (CNS), characterized by multifocal lesions, axonal damage, and progressive neurological dysfunction, imposing a heavy burden on patients and healthcare systems.
Zhiyong Long, Qianyue Yang, Yonghe Wu, Lifei Wan, Liuting Zeng, Lingyun Sun, Poorani Gurumallesh   +6 more
wiley   +1 more source

Active anti-acetylcholinesterase component of secondary metabolites produced by the endophytic fungi of Huperzia serrata

Electronic Journal of Biotechnology, 2015
Background: An endophytic fungus lives within a healthy plant during certain stages of, or throughout, its life cycle. Endophytic fungi do not always cause plant disease, and they include fungi that yield different effects, including mutual benefit, and ...
Zhejian Wang, Zhao Ma, Lili Wang, Chengchen Tang, Zhibi Hu, GuiXin Chou, Wankui Li   +6 more
doaj   +1 more source

Reference gene selection for real‐time quantitative PCR assays in different tissues of Huperzia serrata based on full‐length transcriptome sequencing

Plant Direct, 2021
Huperzia serrata (H. serrata) produces various types of effective lycopodium alkaloids, especially Huperzine A (HupA), which is a promising drug for the treatment of Alzheimer's disease.
Yanping Fu, Fei Niu, Hui Jia, Yanli Wang, Bin Guo, Yahui Wei   +5 more
doaj   +1 more source

Intravitreal injection of Huperzine A promotes retinal ganglion cells survival and axonal regeneration after optic nerve crush

Frontiers in Cellular Neuroscience, 2023
Traumatic optic neuropathy (TON) is a condition that causes massive loss of retinal ganglion cells (RGCs) and their axonal fibers, leading to visual insufficiency. Several intrinsic and external factors can limit the regenerative ability of RGC after TON,
Lai-Yang Zhou, Lai-Yang Zhou, Di Chen, Xin-Ran Guo, Yu-Qian Niu, Yong-Sai Xu, Dong-Fu Feng, Tie-Chen Li   +7 more
doaj   +1 more source

Phytochemical Nanoparticles for the Treatment of Neurological Disorders

Phytochemical Analysis, Volume 36, Issue 7, Page 1918-1935, October 2025.
ABSTRACT Neurological disorders impose a significant burden on the healthcare systems. The latest published data by WHO indicated that stroke was the second leading cause of death globally in 2020, with Alzheimer's disease (AD) and other dementias in the seventh position.
Touraj Ehtezazi, Satyajit D. Sarker
wiley   +1 more source

Acetylation‐Deacetylation‐Driven Natural Product Biosynthesis

ChemistryEurope, Volume 3, Issue 4, July 14, 2025.
This review summarizes the role of acetylation‐deacetylation in natural product biosynthesis, including acetylation followed by deacetylation after several biosynthetic steps, acetylation‐mediated rearrangement, acetylation‐triggered elimination, and the acetylation cycle as a regulatory mechanism. These processes are vital for the formation of complex
Huibin Wang, Ikuro Abe
wiley   +1 more source

Synthetic biology for medical biomaterials

Interdisciplinary Medicine, Volume 3, Issue 4, July 2025.
Synthetic biology platform has been utilized to produce a variety of medical biomaterials (MBMs), such as polylactic acid (PLA), polyhydroxyalkanoates (PHAs), hyaluronic acid (HA), collagen (COL), poly(β‐malic acid) (PMLA), poly‐γ‐glutamic acid (γ‐PGA), alginate (ALG), chitosan (CS), bacterial cellulose (BC), and antimicrobial peptides (AMPs).
Tao Xu, Xiao‐Yun Huang, Jin‐Wei Dao, Da Xiao, Dai‐Xu Wei   +4 more
wiley   +1 more source

Evaluating dietary quality and dietary inflammatory potential in cognitive impairment patients in China

Alzheimer's &Dementia, Volume 21, Issue 6, June 2025.
Abstract INTRODUCTION Diet plays a critical role in the prevention and treatment of cognitive impairment, yet dietary intake in patients with cognitive impairment in China remains insufficiently studied. METHODS A 25‐item semi‐quantitative food frequency questionnaire was used in a national online survey in China.
Dongsheng Bian, Furu Liang, Yong You, Xianfeng Li, Hua Hu, Huali Wang, Huayan Liu, Lu Shen, Oumei Cheng, Qiumin Qu, Shunliang Xu, Weihong Kuang, Qinying Ma, Xiaoping Pan, Xinyu Zhao, Yang Zhang, Yifeng Du, Ying Xu, Yong'an Sun, Zhengluan Liao, Jintao Wang, Jianping Li, Jinwen Xiao, Haixia Li, Xinyi Xie, Zike Yun, Jieli Geng, Wenwei Cao, Nan Zhi, Rujing Ren, Hengge Xie, Gang Wang, representing ADC   +32 more
wiley   +1 more source

Emerging Links Between Ferroptosis and Neurodegeneration: Implications for Disease Mechanisms and Nutraceutical Interventions

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
Ferroptosis, a controlled cell death, is driven by iron and characterized by reactive oxygen species and lipid peroxidation. The impact of lipid peroxides, GSH/GPX4, and iron metabolism–targeting small molecule inhibitors is discussed. Nucleic acids, proteins, and phytochemicals are implicated as inhibitors of ferroptosis.
Anwar Ali, Quratulain Babar, Ayesha Saeed, Domenico Sergi, Nenad Naumovski, Isam A. Mohamed Ahmed, Ghalia Shamlan, Halah Abdulrahman Hafiz, Muhammad Faisal Manzoor, Joanna Trafialek, Felix Kwashie Madilo   +10 more
wiley   +1 more source

In Situ Gels for Nasal Delivery: Formulation, Characterization and Applications

Macromolecular Materials and Engineering, Volume 310, Issue 6, June 2025.
Drug delivery through the nasal route offers many advantages, but is hampered by a number of challenges, such as the short drug retention time caused by mucociliary clearance. In situ forming gels, which undergo a sol‐to‐gel transition with specific triggers at the site of action, present real opportunities in this field.
Li Qian, Michael T. Cook, Cécile A. Dreiss   +2 more
wiley   +1 more source