Results 81 to 90 of about 2,786 (199)
Qualification and quantification of huperzine a from Huperia serrata in Da Lat, Lam Dong province
, 2016 Huperzine A, an alkaloid, was originally isolated from Huperzia serrata. This compound potentially enhances the memory in animal, hence, it has been approved as a drug for the clinical treatment of Alzheimer’s disease, a major disease affecting the ...
Nguyễn Tiến Đạt +4 more
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Frontiers in Plant ScienceIntroductionHuperzine A (HupA) and huperzine B (HupB) are high-value Lycopodiaceae alkaloids with potent, reversible acetylcholinesterase (AChE) inhibitory activity and NMDA receptor antagonism.
Wojciech J. Szypuła +2 more
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Donepezil increases resistance to induced seizures in a mouse model of Dravet syndrome
Annals of Clinical and Translational Neurology, 2019 De novo loss‐of‐function mutations in SCN1A are the main cause of Dravet syndrome, a catastrophic encephalopathy characterized by recurrent early‐life febrile seizures, a number of other afebrile seizure types that are often refractory to treatment, and ...
Jennifer C. Wong +2 more
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Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors
, 1999 Hybrid acetylcholinesterase inhibitors composed of a key fragment of huperzine A and an intact tacrine unit were prepared. The syntheses are quite direct, proceeding in a maximum of 4 linear steps from commercially available starting materials.
Han, Yifan +4 more
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Frontiers in PharmacologyBackgroundVascular dementia (VaD) is one of the most prevalent, burdensome, and costly forms of dementia. Pharmacological treatment is often the first-line choice for clinicians; however, there is a paucity of comparative information regarding the ...
Chun Dang +6 more
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Natural Product Communications, 2009 The alkaloid cryptolepine (1) and eight synthetic analogues (2-8) were assessed for in vitro activities against Trypanosoma brucei . Four of the analogues were found to be highly potent with IC 50 values of less than 3 nM and three of these were assessed
Awotunde J. Oluwafemi +7 more
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HorticulturaeHuperzine A (HupA) is a natural Lycopodium alkaloid known for its potent neuroprotective properties through the inhibition of acetylcholinesterase. Nevertheless, the limited understanding of its biosynthesis restricts its broader application.
Ming Lei +11 more
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Huperzine A: is it an effective disease-modifying drug for Alzheimer’s disease?
Frontiers in Aging Neuroscience, 2014 Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which there is no cure. Huperzine A (HupA) is a natural inhibitor of acetylcholinesterase (AChE) derived from the Chinese folk medicine Huperzia serrata (Qian Ceng Ta).
Zhong Ming eQian, Ya eKe
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Doença de Alzheimer e Huperzine Huperzine A for Alzheimer's disease Synopsis
, 2020 There is currently insufficient evidence of the effects of Huperzine A for Alzheimer's disease (AD). Huperzine A is derived from Chinese club moss Huperzia serrata, and is described as having several properties which may be beneficial for AD.
J Li, Dong Br, Liu Gj, Wu Hm, Zhou Rl
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Synthesis of 7-desmethyl analogs of (+)- and (-)-huperzine A
, 2015 The natural alkaloid (-)-huperzine A is an inhibitor of AChE and has been demonstrated to exert neuroprotection and to possess beneficial effects on other CNS related disorders. In this manuscript, we report the synthesis of the analogs of huperzine A in
PIERONI, Marco, Tipparaju, Suresh K.
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