Huperzine A for vascular dementia [PDF]
Cochrane Database of Systematic Reviews, 2008 Huperzine A, a form of herbal medicine, has been considered as an alternative treatment for vascular dementia (VaD) in China.To assess the efficacy and safety of Huperzine A in patients with vascular dementia.The Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (CDCIG) was searched on 7 July 2008 using the terms: huperzi ...
Zilong, Hao +3 more
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Current Plant Biology, 2020 Chinese toothed clubmoss (Huperzia serrata) is a primitive fern native in certain types of forests. It is severely endangered in China due to its difficult propagation and massive hunting for huperzine A to improve and prevent Alzheimer’s disease.
Qing-Zhong Peng +4 more
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Neuroprotective Effect of Huperzine A on -Galactose-Induced Hearing Dysfunction
Ear, Nose & Throat Journal, 2021 Background: Administration of d -galactose ( d -gal) has been used to create animal models of neurodegenerative diseases, and huperzine A has been used to treat the neurodegenerative diseases such as Alzheimer disease. Methods: An animal model of hearing
Cong Li MM, Song Shi MD
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Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine−Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's Disease [PDF]
, 1999 Eleven new 12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline derivatives [tacrine (THA)−huperzine A hybrids, rac-21−31] have been synthesized as racemic mixtures and tested as acetylcholinesterase (AChE) inhibitors.
Badia, Albert +21 more
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Huperzine A attenuates nonalcoholic fatty liver disease by regulating hepatocyte senescence and apoptosis: an in vitro study [PDF]
PeerJ, 2018 Objective This study was undertaken to detect if free fatty acids (FFA) induce hepatocyte senescence in L-02 cells and if huperzine A has an anti-aging effect in fatty liver cells.
Xiao-na Hu +6 more
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New Tacrine−Huperzine A Hybrids (Huprines): Highly Potent Tight-Binding Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease [PDF]
, 2000 Several new 12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline derivatives (tacrine−huperzine A hybrids, huprines) have been synthesized and tested as acetylcholinesterase (AChE) inhibitors.
Badia, Albert +9 more
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Molecules, 2020 This is the first report of an efficient and effective procedure to optimize the biosynthesis of huperzine A (HupA) and huperzine B (HupB) in vitro from Huperzia selago gametophytes. Axenic tissue cultures were established using spores collected from the
Wojciech J. Szypuła +3 more
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Natural Product Communications, 2021 Huperzine A, isolated from Huperzia serrata, is a potent, specific, and reversible inhibitor of acetylcholinesterase with high efficiency and low toxicity.
Ngoc Chuong Nguyen +5 more
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Huperzine A - An Interesting Anticholinesterase Compound from the Chinese Herbal Medicine
Acta Medica, 1998 Huperzine A, alkaloid from the Chinese herbal medicine Qian Ceng Ta, which is prepared from the moss Huperzia serrata, has been used in China for centuries to treat fever and inflammation.
Jiří Patočka
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Biosynthesis of plant neuroactive alkaloids treating Alzheimer’s disease [PDF]
Frontiers in PharmacologyQuanyu Yin, Zhengkang Zhu, Mengquan Yang
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