Results 11 to 20 of about 1,924 (168)

<i>Huperzia javanica</i> as a Novel Source of Huperzine Alkaloids and Huperzine-producing Fungi. [PDF]

Indian J Microbiol
Huperzine A (HupA) and huperzine B (HupB) are potent acetylcholinesterase inhibitor used widely for clinical treatment of Alzheimer's disease, which are mainly extracrted from natural populations of Huperzia species. This study aimed to the evaluate potential of producing Hup of native Huperzia javanica species collected in Vietnam as well as identify ...
Le TTM, Pham HT, Trinh HTT, Quach NT, Do TT, Phi QT, Chu HH.   +6 more
europepmc   +3 more sources

Natural Chiral Scaffolds in Alzheimer's Disease: Therapeutic Potential, Mechanism, and Clinical Aspects. [PDF]

Biomed Res Int
Alzheimer′s disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive cognitive impairment, amyloid‐β deposition, tau pathology, oxidative stress, neuroinflammation, and dysfunction of synapses. Current therapeutic options are largely symptomatic and lack disease‐modifying efficacy.
Singh A, Sahu SK, Sah AK.
europepmc   +2 more sources

De novo RNA sequencing and transcriptome analysis of Colletotrichum gloeosporioides ES026 reveal genes related to biosynthesis of huperzine A. [PDF]

PLoS ONE, 2015
Huperzine A is important in the treatment of Alzheimer's disease. There are major challenges for the mass production of huperzine A from plants due to the limited number of huperzine-A-producing plants, as well as the low content of huperzine A in these ...
Guowei Zhang, Wenjuan Wang, Xiangmei Zhang, Qianqian Xia, Xinmei Zhao, Youngjoon Ahn, Nevin Ahmed, Andreea Cosoveanu, Mo Wang, Jialu Wang, Shaohua Shu   +10 more
doaj   +1 more source

Integration of System Biology Tools to Investigate Huperzine A as an Anti-Alzheimer Agent

Frontiers in Pharmacology, 2021
Aim: The present study aimed to investigate huperzine A as an anti-Alzheimer agent based on the principle that a single compound can regulate multiple proteins and associated pathways, using system biology tools.Methodology: The simplified molecular ...
Pukar Khanal, Farshid Zargari, Farshid Zargari, Bahareh Farasati Far, Dharmendra Kumar, Mogana R, Yasir K. Mahdi, Najwan K. Jubair, Shailendra K. Saraf, Parveen Bansal, Ranjit Singh, Malarvili Selvaraja, Yadu Nandan Dey   +12 more
doaj   +1 more source

Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease

Molecules, 2021
Huperzine A (HupA), an alkaloid found in the club moss Huperzia serrata, has been used for centuries in Chinese folk medicine to treat dementia.
María Jesús Friedli, Nibaldo C. Inestrosa   +1 more
doaj   +1 more source

Involvement of Intracellular and Mitochondrial Aβ in the Ameliorative Effects of Huperzine A against Oligomeric Aβ42-Induced Injury in Primary Rat Neurons. [PDF]

PLoS ONE, 2015
Considerable studies indicate huperzine A is a promising natural product to suppress neuronal damages induced by β-amyloid (Aβ), a key pathogenic event in the Alzheimer's disease (AD).
Yun Lei, Ling Yang, Chun Yan Ye, Ming Yan Qin, Huai Yu Yang, Hua Liang Jiang, Xi Can Tang, Hai Yan Zhang   +7 more
doaj   +1 more source

Biosynthesis of plant neuroactive alkaloids treating Alzheimer’s disease [PDF]

Frontiers in Pharmacology
Quanyu Yin, Zhengkang Zhu, Mengquan Yang
doaj   +2 more sources

Return to Spontaneous Circulation in a Patient With Cholinergic Syndrome at the Emergency Department of Buea Regional Hospital, Cameroon. [PDF]

Clin Case Rep
ABSTRACT With the increasing misuse of herbal treatment and pesticides, cases of cholinergic syndrome following herbal treatment or organophosphate poisoning have become increasingly common in our milieu. However, when advanced, mortality is high. We report the successful management of a case involving a 54‐year‐old African female with a known history ...
Nteungue BBK, Nyuydzefon B, Kouomogne BAN, Siysi VV.   +3 more
europepmc   +2 more sources

Comparative efficacy of pharmacotherapy and non‐pharmacotherapy for treating Alzheimer's disease: A systematic review and network meta‐analysis for cognitive, behavior and functional outcomes [PDF]

Alzheimers Dement
Abstract Importance Alzheimer's disease (AD), the most prevalent form of dementia, contributes significantly to global disability. Pharmacotherapies (PTs) often have adverse effects, while diverse non‐pharmacotherapies (NPTs) lack comprehensive comparative evaluations against PTs.
Boongird C, Tearneukit W, Wongpipathpong W, Suthutvoravut U, Thongpan M, Pongsettakul N, McKay G, Rattanasiri S, Anothaisintawee T, Thakkinstian A.   +9 more
europepmc   +2 more sources

Huperzine A for vascular dementia [PDF]

Cochrane Database of Systematic Reviews, 2008
Huperzine A, a form of herbal medicine, has been considered as an alternative treatment for vascular dementia (VaD) in China.To assess the efficacy and safety of Huperzine A in patients with vascular dementia.The Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (CDCIG) was searched on 7 July 2008 using the terms: huperzi ...
Zilong, Hao, Ming, Liu, Zhiqin, Liu, Donghao, Lv   +3 more
openaire   +2 more sources