The pharmacology and therapeutic potential of (-)-huperzine A
Journal of Experimental Pharmacology, 2012 Maung Kyaw Moe Tun, Seth B HerzonDepartment of Chemistry, Yale University, New Haven, CT, USAAbstract: (–)-Huperzine A (1) is an alkaloid isolated from a Chinese club moss.
Tun MK, Herzon SB
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Total Synthesis of (−)-Huperzine A [PDF]
Organic Letters, 2009 The total synthesis of huperzine Q was accomplished. The synthesis features the construction of the cis-hydrindane skeleton via a Diels-Alder reaction and a ring contraction reaction of an epoxyketone.
Toshimune Nomura +2 more
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PLoS ONE, 2013 BackgroundHuperzine A is a Chinese herb extract used for Alzheimer's disease. We conducted this review to evaluate the beneficial and harmful effect of Huperzine A for treatment of Alzheimer's disease.MethodsWe searched for randomized clinical trials ...
Guoyan Yang +3 more
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Examining the interactome of huperzine A by magnetic biopanning. [PDF]
PLoS ONE, 2012 Huperzine A is a bioactive compound derived from traditional Chinese medicine plant Qian Ceng Ta (Huperzia serrata), and was found to have multiple neuroprotective effects.
Wei Guo +8 more
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Synthetic approaches to huperzine A
, 2018 The natural product huperzine A has been found to possess activity as a nootropic agent. Because of its memory facilitating effects, huperzine A represents a promising drug for the treatment of neurodegenerative diseases, such as Alzheimer's disease.
Vines, Danette
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Isolation and purification of Huperzine A
浙江大学学报. 农业与生命科学版, 2002 Technique of isolation and purification of Huperzine A from Huperzia serrata (Thunb) Trev. was studied in this paper. To get rid of some pigments and other impurities, some of chemical techniques for separation such as extraction with organic acid ...
SHEN Sheng-rong +3 more
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Divergent Total Synthesis of the Lycopodium Alkaloids Huperzine A, Huperzine B, and Huperzine U
, 2016 Huperzine A, huperzine B, and huperzine U are congeners isolated from the Chinese herb Huperzia serrata (=Lycopodium serratum) in minuscule amounts. The most efficient total synthesis of huperzine A, the first asymmetric total syntheses of huperzine B ...
Bing-Feng Sun (1863463) +4 more
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Neuroprotective Effects of Huperzine B and <i>Huperzia carinata</i> Extract Against MPP<sup>+</sup>-Induced Oxidative Stress in SH-SY5Y Cells. [PDF]
Adv Pharmacol Pharm SciParkinson’s disease (PD) is a neurodegenerative disorder associated with dopaminergic neuronal loss, mitochondrial dysfunction, and redox imbalance. Huperzine B (HupB), an alkaloid derived from Huperzia species, has demonstrated antioxidant and acetylcholinesterase‐inhibitory activity; however, its effects in toxin‐induced cellular models of ...
Viwatpinyo K +6 more
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Valorization of Ficus carica Pruning Residues as Selective Botanical Insecticides: Optimized Furanocoumarin Extraction, Efficacy Against Neotropical Stink Bugs, and Mechanistic Insights via Molecular Docking. [PDF]
Arch Insect Biochem PhysiolOptimized extracts from Ficus carica pruning waste exhibit strong biological activity against major stink bug pests. Complementary in silico analyses suggest this efficacy relies on pest‐specific acetylcholinesterase inhibition, predicting a promising, pollinator‐safe alternative for sustainable agriculture.
Almeida TA +7 more
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Natural Chiral Scaffolds in Alzheimer's Disease: Therapeutic Potential, Mechanism, and Clinical Aspects. [PDF]
Biomed Res IntAlzheimer′s disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive cognitive impairment, amyloid‐β deposition, tau pathology, oxidative stress, neuroinflammation, and dysfunction of synapses. Current therapeutic options are largely symptomatic and lack disease‐modifying efficacy.
Singh A, Sahu SK, Sah AK.
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