Results 41 to 50 of about 114,626,959 (164)
Phytochemicals in Food and Medicine, Volume 1, Issue 1, March 2026.This PROSPERO‐registered review analysed 37 RCTs on neuronutraceuticals for Alzheimer's disease. Despite diverse targets—amyloid/tau, inflammation, oxidative stress, metabolism, synaptic plasticity, cholinergic and hormonal—the evidence was of low quality. RoB2 flagged attrition (86.5%) and reporting bias (81%). Current data do not support clinical use;
Mehmet Akif Topcuoglu, Esen Saka
wiley +1 more source
Total Synthesis of Huperzine R
, 2017 A total synthesis of huperzine R was accomplished. Intramolecular cycloaddition of a nitrile oxide and reductive cleavage of the resulting isoxazoline induced sequential cleavage of the C–C and C–O bonds to form the characteristic bicyclic lactam core ...
Satoshi Yokoshima +5 more
core +1 more source
Bis-huperzine B: Highly Potent and Selective Acetylcholinesterase Inhibitors
, 2016 By targeting dual active sites of AChE, a series of bis-huperzine B analogues with various lengths of the tether were designed, synthesized, and tested for their inhibition and selectivity.
Hualiang Jiang (19452) +7 more
core +2 more sources
Rapid Structural Analysis of Natural Products Using MicroED
Small, Volume 22, Issue 15, 12 March 2026.The cryoEM method, MicroED used for rapid analysis and structure determination of natural products that remained unattainable by other structural biology methods ABSTRACT Structural analysis of natural products remains challenging due to their inherent complexity and limited availability.
Jieye Lin +3 more
wiley +1 more source
Correction to Total Synthesis of (−)-Huperzine A
, 2016 Correction to Total Synthesis of ...
Takahiro Koshiba (1843504) +2 more
core +1 more source
IET Systems Biology, Volume 20, Issue 1, January/December 2026.This study elucidates pesticide docking onto proteins encoded by differentially expressed genes, revealing interaction networks involving chemicals, genes, proteins, drugs and diseases. It highlights structural insights, regulatory pathways and potential therapeutic or environmental implications, providing a comprehensive understanding of the ...
Jyoti Kant Choudhari +4 more
wiley +1 more source
, 2005 The definitive version is available from www.wiley.comHuperzine A (HupA) and huperzine B (HupB) are two medically important components of Huperzia serrata.
Bi, J. +13 more
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Development of methods for synthesis of the huperzine alkaloids
, 2000 The primary goal of this project is to explore the synthesis of huperzine alkaloids via the photoinitiated intramolecular ylide alkene cylcloaddition. Huperzine A and B are both potent inhibitors of acetylcholinesterase, the enzyme responsible for the ...
Contonio, Brooke Diane
core +3 more sources
Synthesis of (±)-Serralongamine A and the Revised Structure of Huperzine N [PDF]
, 2019 A revised structure for the Lycopodium alkaloid huperzine N is proposed and confirmed by synthesis. The key synthetic steps involve an epimerization of a cis-5-oxodecahydroquinoline to the corresponding trans isomer and a coupling, followed by a ...
Bradshaw, Ben +4 more
core +1 more source
Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.Diabetic retinopathy (DR) is a leading cause of blindness worldwide, characterized by retinal vascular dysfunction, oxidative stress, inflammation, and neuronal degeneration. Flavonoids such as hesperidin (HSD), hesperetin (HST), and naringenin, commonly found in citrus fruits, have shown promise in mitigating DR through multiple molecular mechanisms ...
Guangling Feng +2 more
wiley +1 more source