Results 61 to 70 of about 114,626,959 (164)
The determination of huperzine A in european Lycopodiaceae species by HPLC-UV-MS
, 2006 A rapid qualitative HPLC-UV-MS method was developed for the detection of huperzine A in Lycopodiaceac species. HPLC coupled with mass spectrometry experiments allowed the identification of the alkaloid and enabled targeted analysis of complex matrices ...
Borloz, A. +2 more
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Synthesis of 7-desmethyl analogs of (+)- and (-)-huperzine A
, 2015 The natural alkaloid (-)-huperzine A is an inhibitor of AChE and has been demonstrated to exert neuroprotection and to possess beneficial effects on other CNS related disorders. In this manuscript, we report the synthesis of the analogs of huperzine A in
PIERONI, Marco, Tipparaju, Suresh K.
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Structural analogs of huperzine A improve survival in guinea pigs exposed to soman
, 2013 Chemical warfare nerve agents such as soman exert their toxic effects through an irreversible inhibition of acetylcholinesterase (AChE) and subsequently glutamatergic function, leading to uncontrolled seizures.
Hendra Gunosewoyo (1648369) +6 more
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, 2013 BackgroundHuperzine A is a Chinese herb extract used for Alzheimer's disease. We conducted this review to evaluate the beneficial and harmful effect of Huperzine A for treatment of Alzheimer's disease.MethodsWe searched for randomized clinical trials ...
Yuyi Wang (462133) +7 more
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Huperzine A: A nootropic agent in the shade [Huperzin A: Gölgede Kalmış bir Nootropik Ajan]
, 2019 Huperzine A is a sesquiterpene alkaloid found in the chemical composition of the medical plant Huperzia serrata. Huperzine A has attracted the attention of neuroscientists after the discovery of its strong and selective inhibitory activity on the ...
Turan, Yücel, N., Can, Özgür Devrim
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Huperzine A decreased mitochondrial accumulation of Aβ42.
, 2015 A. The schematic diagram of the proportion of mitochondria-enriched fraction Aβ42 in total intracellular Aβ42. B. Effect of huperzine A on the level of Aβ42 in different subcellular fractions (N = 4).
Hai Yan Zhang (589189) +7 more
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A concise and convergent (formal) total synthesis of huperzine A
, 2007 The first convergent synthesis of the tricyclic skeleton of huperzine A is described and includes, as the key step, an efficient regioselective intramolecular Heck reaction of 2-(tert-butyldimethylsillyoxymethyl)-6-(2-methoxy-5-bromopyridin-6-yl ...
Kelly, S., Lucey, C., Mann, John
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A palladium-catalyzed synthetic approach to new huperzine analogues modified at the pyridone ring.
, 2003 The synthesis of two new Huperzine A analogues is reported. Both products present an amino substituted benzo-fused system in place of the pyridone ring of the natural alkaloid.
BELLEBAUN K. +8 more
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Isolation and purification of Huperzine A
浙江大学学报. 农业与生命科学版, 2002 Technique of isolation and purification of Huperzine A from Huperzia serrata (Thunb) Trev. was studied in this paper. To get rid of some pigments and other impurities, some of chemical techniques for separation such as extraction with organic acid, absorption with charcol and re-crystallization with chloroform were employed. The results suggested that:
SHEN Sheng-rong +3 more
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The Clinical Analysis of Combined Effects of Huperzine A and Memantine for Alzheimer’s Disease
The purpose of this study was to evaluate the clinical effects of a combination of Huperzine A and memantine for the treatment of Alzheimer’s disease (AD).
Maolong Gao, Shouzi Zhang, Qinyun Li
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