, 2000 rac-Huperzine A, its rac-7-ethyl-derivative and two regioisomeric analogues have been prepared through synthetic sequences involving the elaboration of the pyridone ring in a late stage, by reaction of an intermediate pyrrolidine enamine with ...
Badia, Albert +8 more
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Protective effect of huperzine A on phenytoin induced cognition impairment: Behavioral and biochemical study [PDF]
, 2022 205-213Phenytoin, a drug of choice for Epilepsy is also known for its adverse effects. The most common adverse effect due to phenytoin is cognition impairment.
Dubey (Upadhyay), Shagun
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Journal of Immunology Research, Volume 2026, Issue 1, 2026.Multiple sclerosis (MS) is a chronic immune‐mediated inflammatory demyelinating disease of the central nervous system (CNS), characterized by multifocal lesions, axonal damage, and progressive neurological dysfunction, imposing a heavy burden on patients and healthcare systems.
Zhiyong Long +6 more
wiley +1 more source
De novo RNA sequencing and transcriptome analysis of Colletotrichum gloeosporioides ES026 reveal genes related to biosynthesis of huperzine A. [PDF]
, 2015 Huperzine A is important in the treatment of Alzheimer's disease. There are major challenges for the mass production of huperzine A from plants due to the limited number of huperzine-A-producing plants, as well as the low content of huperzine A in these ...
Xiangmei Zhang +10 more
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Evaluation of acetylcholinesterase and butyrylcholinesterase inhibitory activity of Huperzine-A; in silico and in vitro studies [PDF]
, 2019 The present study is focused on exploring the Acetylcholinesterase and Butyrylcholinesterase inhibitory activity of Huperzine-A in silico and in vitro. In this study, Huperzine-A-A was docked with Acetylcholinesterase and Butyrylcholinesterase.
Kohli, Seema +3 more
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Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors
, 1999 Hybrid acetylcholinesterase inhibitors composed of a key fragment of huperzine A and an intact tacrine unit were prepared. The syntheses are quite direct, proceeding in a maximum of 4 linear steps from commercially available starting materials.
Han, Yifan +4 more
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Qualification and quantification of huperzine a from Huperia serrata in Da Lat, Lam Dong province
, 2016 Huperzine A, an alkaloid, was originally isolated from Huperzia serrata. This compound potentially enhances the memory in animal, hence, it has been approved as a drug for the clinical treatment of Alzheimer’s disease, a major disease affecting the ...
Nguyễn Tiến Đạt +4 more
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Doença de Alzheimer e Huperzine Huperzine A for Alzheimer's disease Synopsis
, 2020 There is currently insufficient evidence of the effects of Huperzine A for Alzheimer's disease (AD). Huperzine A is derived from Chinese club moss Huperzia serrata, and is described as having several properties which may be beneficial for AD.
J Li, Dong Br, Liu Gj, Wu Hm, Zhou Rl
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Huperzine A attenuates apoptosis and mitochondria-dependent caspase-3 in rat cortical neurons [PDF]
, 2002 The neuroprotection of huperzine A against apoptosis was investigated. In cultures of rat primary cortical neurons, neuronal apoptosis was induced by serum deprivation for 24 h, which was accompanied by enhanced caspase-3 activity and the release of ...
Xi Can Tang +3 more
core +1 more source
Examining the Interactome of Huperzine A by Magnetic Biopanning
PLoS ONE, 2012 Huperzine A is a bioactive compound derived from traditional Chinese medicine plant Qian Ceng Ta (Huperzia serrata), and was found to have multiple neuroprotective effects. In addition to being a potent acetylcholinesterase inhibitor, it was thought to act through other mechanisms such as antioxidation, antiapoptosis, etc.
Wei Guo +8 more
openaire +4 more sources