Results 51 to 60 of about 1,873 (124)

Phytochemical Nanoparticles for the Treatment of Neurological Disorders

Phytochemical Analysis, Volume 36, Issue 7, Page 1918-1935, October 2025.
ABSTRACT Neurological disorders impose a significant burden on the healthcare systems. The latest published data by WHO indicated that stroke was the second leading cause of death globally in 2020, with Alzheimer's disease (AD) and other dementias in the seventh position.
Touraj Ehtezazi, Satyajit D. Sarker
wiley   +1 more source

A drug screening toolkit based on the –1 ribosomal frameshifting of SARS-CoV-2

Heliyon, 2020
The –1 ribosomal frameshifting is vital for the translation of the open reading frame (ORF)1b in SARS-CoV-2. The products of ORF1b participate in viral replication. Therefore, changing the frameshift frequency reduces the survival of the virus.
Yanqiong Chen, Huan Tao, Silan Shen, Zhiyong Miao, Lili Li, Yongqian Jia, Hu Zhang, Xiufeng Bai, Xinyuan Fu   +8 more
doaj   +1 more source

Acetylation‐Deacetylation‐Driven Natural Product Biosynthesis

ChemistryEurope, Volume 3, Issue 4, July 14, 2025.
This review summarizes the role of acetylation‐deacetylation in natural product biosynthesis, including acetylation followed by deacetylation after several biosynthetic steps, acetylation‐mediated rearrangement, acetylation‐triggered elimination, and the acetylation cycle as a regulatory mechanism. These processes are vital for the formation of complex
Huibin Wang, Ikuro Abe
wiley   +1 more source

Rapid HPLC-ESI-MS/MS Analysis of Neurotransmitters in the Brain Tissue of Alzheimer’s Disease Rats before and after Oral Administration of Xanthoceras sorbifolia Bunge

Molecules, 2018
In order to explore the potential therapeutic effect of Xanthoceras sorbifolia Bunge. against Alzheimer’s disease, an HPLC-MS/MS method has been developed and validated for simultaneous determination in rat brain of eight neurotransmitters ...
Zheng Sun, Qing Li, Kaishun Bi
doaj   +1 more source

Synthetic biology for medical biomaterials

Interdisciplinary Medicine, Volume 3, Issue 4, July 2025.
Synthetic biology platform has been utilized to produce a variety of medical biomaterials (MBMs), such as polylactic acid (PLA), polyhydroxyalkanoates (PHAs), hyaluronic acid (HA), collagen (COL), poly(β‐malic acid) (PMLA), poly‐γ‐glutamic acid (γ‐PGA), alginate (ALG), chitosan (CS), bacterial cellulose (BC), and antimicrobial peptides (AMPs).
Tao Xu, Xiao‐Yun Huang, Jin‐Wei Dao, Da Xiao, Dai‐Xu Wei   +4 more
wiley   +1 more source

Evaluating dietary quality and dietary inflammatory potential in cognitive impairment patients in China

Alzheimer's &Dementia, Volume 21, Issue 6, June 2025.
Abstract INTRODUCTION Diet plays a critical role in the prevention and treatment of cognitive impairment, yet dietary intake in patients with cognitive impairment in China remains insufficiently studied. METHODS A 25‐item semi‐quantitative food frequency questionnaire was used in a national online survey in China.
Dongsheng Bian, Furu Liang, Yong You, Xianfeng Li, Hua Hu, Huali Wang, Huayan Liu, Lu Shen, Oumei Cheng, Qiumin Qu, Shunliang Xu, Weihong Kuang, Qinying Ma, Xiaoping Pan, Xinyu Zhao, Yang Zhang, Yifeng Du, Ying Xu, Yong'an Sun, Zhengluan Liao, Jintao Wang, Jianping Li, Jinwen Xiao, Haixia Li, Xinyi Xie, Zike Yun, Jieli Geng, Wenwei Cao, Nan Zhi, Rujing Ren, Hengge Xie, Gang Wang, representing ADC   +32 more
wiley   +1 more source

Emerging Links Between Ferroptosis and Neurodegeneration: Implications for Disease Mechanisms and Nutraceutical Interventions

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
Ferroptosis, a controlled cell death, is driven by iron and characterized by reactive oxygen species and lipid peroxidation. The impact of lipid peroxides, GSH/GPX4, and iron metabolism–targeting small molecule inhibitors is discussed. Nucleic acids, proteins, and phytochemicals are implicated as inhibitors of ferroptosis.
Anwar Ali, Quratulain Babar, Ayesha Saeed, Domenico Sergi, Nenad Naumovski, Isam A. Mohamed Ahmed, Ghalia Shamlan, Halah Abdulrahman Hafiz, Muhammad Faisal Manzoor, Joanna Trafialek, Felix Kwashie Madilo   +10 more
wiley   +1 more source

In Situ Gels for Nasal Delivery: Formulation, Characterization and Applications

Macromolecular Materials and Engineering, Volume 310, Issue 6, June 2025.
Drug delivery through the nasal route offers many advantages, but is hampered by a number of challenges, such as the short drug retention time caused by mucociliary clearance. In situ forming gels, which undergo a sol‐to‐gel transition with specific triggers at the site of action, present real opportunities in this field.
Li Qian, Michael T. Cook, Cécile A. Dreiss   +2 more
wiley   +1 more source

A new and fast method to obtain in vitro cultures of Huperzia selago (Huperziaceae) sporophytes, a club moss which is a source of huperzine A

Acta Societatis Botanicorum Poloniae, 2013
This study presents a protocol for a fast and effective in vitro axenic culture of Huperzia selago (Huperziaceae Rothm.) sporophytes, a club moss which is a source of huperzine A, an alkaloid of a considerable therapeutic potential extensively ...
Wojciech J. Szypuła, Paulina Mistrzak, Olga Olszowska   +2 more
doaj   +1 more source

The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases

MedComm, Volume 6, Issue 6, June 2025.
Τhe BBB restricts CNS drug delivery. NBDD bypasses the BBB via olfactory/trigeminal routes, enabling CNS delivery of therapeutic (small molecules, biologics, nucleic acids) for neurodegenerative/psychiatric disorders and brain tumors using advanced NBDD delivery systems (e.g nanocarriers) to enhance targeting and bioavailability.
Yi Qiu, Shiyuan Huang, Li Peng, Li Yang, Guosong Zhang, Tao Liu, Fang Yan, Xi Peng   +7 more
wiley   +1 more source