Results 21 to 30 of about 12,358,109 (167)
Natural Product Communications, 2009 Three Lycopodiaceae species from French Polynesia, Lycopodium venustulum C. Gaudichaud, Lycopodiella cernua (C. Linnaeus) R. E. Pichi Sermolli and Lycopodium henryanum E. D.
Raimana Ho +4 more
doaj +1 more source
Development of huperzine A and B for treatment of Alzheimer's disease [PDF]
Pure and Applied Chemistry, 2007 Abstract Recent studies have proved that huperzine A (HupA) possesses different pharmacological actions other than the inhibition of hydrolysis of ACh. These noncholinergic roles, for instance, the antagonist effect on NMDA receptor, the protection of neuronal cells against β-amyloid, free radicals, and hypoxia-ischemia-induced injury ...
openaire +1 more source
Bis-huperzine B: Highly Potent and Selective Acetylcholinesterase Inhibitors
, 2016 By targeting dual active sites of AChE, a series of bis-huperzine B analogues with various lengths of the tether were designed, synthesized, and tested for their inhibition and selectivity.
Hualiang Jiang (19452) +7 more
core +2 more sources
Molecules, 2019 Lycopodii Herba is a widely used traditional medicinal herb, and contains diverse fascinating alkaloids. In this study, a fast and sensitive LC-MS/MS method for the simultaneous determination of lycodoline, α-obscurine, and N-demethyl-α ...
Dongke Ma +4 more
doaj +1 more source
Development of methods for synthesis of the huperzine alkaloids
, 2000 The primary goal of this project is to explore the synthesis of huperzine alkaloids via the photoinitiated intramolecular ylide alkene cylcloaddition. Huperzine A and B are both potent inhibitors of acetylcholinesterase, the enzyme responsible for the ...
Contonio, Brooke Diane
core +3 more sources
Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy
Phytotherapy Research, EarlyView.This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi +9 more
wiley +1 more source
Phytotherapy Research, EarlyView.Research landscape and mechanistic insights into natural medicines for Alzheimer's disease. ABSTRACT Natural medicines have been widely investigated for Alzheimer's disease (AD), but the development of this field and the relationship between bibliometric themes and experimental evidence remain insufficiently characterized.
Maoning Wang +8 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.ABSTRACT This current study aimed to decipher the anti‐inflammatory, anti‐ferroptosis and pronounced lung‐protective activities of Salvianolic acid B (Sal B) by integrating network pharmacology and experimental confirmation across multiple aspects. The optimal target protein and the relevant molecular mechanisms for Sal B in the context of ALI were ...
Hejun Gao +4 more
wiley +1 more source
Frontiers in Plant ScienceIntroductionHuperzine A (HupA) and huperzine B (HupB) are high-value Lycopodiaceae alkaloids with potent, reversible acetylcholinesterase (AChE) inhibitory activity and NMDA receptor antagonism.
Wojciech J. Szypuła +2 more
doaj +1 more source
Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies
Advanced Science, Volume 13, Issue 47, 24 August 2026.This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang +7 more
wiley +1 more source