Results 11 to 20 of about 12,358,109 (167)

Infraspecific Variation of Huperzine A and B in Icelandic Huperzia selago Complex [PDF]

Planta Medica, 2018
AbstractThe alkaloids huperzine A and huperzine B were originally isolated from the Chinese club moss Huperzia serrata. They are known inhibitors of acetylcholinesterase, and especially huperzine A shows pharmaceutical potential for the treatment of Alzheimerʼs disease. Its supply heavily relies on natural plant sources belonging to the genus Huperzia,
Xu, Maonian, Heiðmarsson, Starri, Thorsteinsdóttir, Margrét, Wasowicz, Pawel, Sun, Hang, Deng, Tao, Omarsdottir, Sesselja, Olafsdottir, Elin Soffia   +7 more
openaire   +6 more sources

The pharmacology and therapeutic potential of (-)-huperzine A

Journal of Experimental Pharmacology, 2012
Maung Kyaw Moe Tun, Seth B HerzonDepartment of Chemistry, Yale University, New Haven, CT, USAAbstract: (–)-Huperzine A (1) is an alkaloid isolated from a Chinese club moss.
Tun MK, Herzon SB
doaj   +1 more source

Divergent Total Synthesis of the Lycopodium Alkaloids Huperzine A, Huperzine B, and Huperzine U

, 2016
Huperzine A, huperzine B, and huperzine U are congeners isolated from the Chinese herb Huperzia serrata (=Lycopodium serratum) in minuscule amounts. The most efficient total synthesis of huperzine A, the first asymmetric total syntheses of huperzine B ...
Bing-Feng Sun (1863463), Guo-Qiang Lin (1589989), Guang-Qiang Xu (1863460), Rui Ding (423236), Jian-Guo Fu (1863457)   +4 more
core   +6 more sources

Valorization of Ficus carica Pruning Residues as Selective Botanical Insecticides: Optimized Furanocoumarin Extraction, Efficacy Against Neotropical Stink Bugs, and Mechanistic Insights via Molecular Docking. [PDF]

Arch Insect Biochem Physiol
Optimized extracts from Ficus carica pruning waste exhibit strong biological activity against major stink bug pests. Complementary in silico analyses suggest this efficacy relies on pest‐specific acetylcholinesterase inhibition, predicting a promising, pollinator‐safe alternative for sustainable agriculture.
Almeida TA, Páez AR, Costa LTM, Smagghe G, Cardoso YM, Faria LM, Oliveira EE, Leite JPV.   +7 more
europepmc   +2 more sources

Natural Chiral Scaffolds in Alzheimer's Disease: Therapeutic Potential, Mechanism, and Clinical Aspects. [PDF]

Biomed Res Int
Alzheimer′s disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive cognitive impairment, amyloid‐β deposition, tau pathology, oxidative stress, neuroinflammation, and dysfunction of synapses. Current therapeutic options are largely symptomatic and lack disease‐modifying efficacy.
Singh A, Sahu SK, Sah AK.
europepmc   +2 more sources

Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine−Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's Disease [PDF]

, 1999
Eleven new 12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline derivatives [tacrine (THA)−huperzine A hybrids, rac-21−31] have been synthesized as racemic mixtures and tested as acetylcholinesterase (AChE) inhibitors.
Badia, Albert, Vivas, Nuria María, Orozco, Modesto, Morral-Cardoner, Jordi, Barril, Xavier, Görbig, Diana Marina, Baños, Josep Eladi, Camps, Pelayo, Muñoz-Torrero, Diego, El Achab, Rachid, Luque, Francisco Javier, Xavier Barril, Francisco Javier Luque, Nuria María Vivas, Pelayo Camps, Jordi Morral, Modesto Orozco, Diana Marina Görbig, Albert Badia, Rachid El Achab, Josep Eladi Baños, Diego Muñoz-Torrero   +21 more
core   +1 more source

Lycodine-Type Alkaloids from Lycopodiastrum casuarinoides and Their Acetylcholinesterase Inhibitory Activity

Molecules, 2014
Four new lycodine-type alkaloids, namely 16-hydroxyhuperzine B (1), N-methyl-11-acetoxyhuperzine B (2), 8,15-dihydrolycoparin A (3) and (7S,12S,13R)-huperzine D-16-O-β-d-glucopyranoside (4), along with ten known analogues 5−14, were isolated from the ...
Dong-Bo Zhang, Jian-Jun Chen, Qiu-Yan Song, Li Zhang, Kun Gao   +4 more
doaj   +1 more source

New Tacrine−Huperzine A Hybrids (Huprines): Highly Potent Tight-Binding Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease [PDF]

, 2000
Several new 12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline derivatives (tacrine−huperzine A hybrids, huprines) have been synthesized and tested as acetylcholinesterase (AChE) inhibitors.
Badia, Albert, Vivas, Nuria María, Orozco, Modesto, Morral-Cardoner, Jordi, Barril, Xavier, Baños, Josep Eladi, Camps, Pelayo, Muñoz-Torrero, Diego, El Achab, Rachid, Luque, Francisco Javier   +9 more
core   +1 more source

Anti-Cholinesterase Activity of Lycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis

Molecules, 2014
A series of Lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8α-hydrophlemariurine B (5), and huperzinine (6), has been isolated from Vietnamese Huperzia squarrosa.
Nguyen Ngoc Chuong, Nguyen Thi Thu Huong, Tran Manh Hung, Tran Cong Luan   +3 more
doaj   +1 more source

A Novel Way for Propagation of Huperzia squarrosa (G. Forst.) Trev.

Notulae Scientia Biologicae, 2012
Huperzia squarrosa (G. Forst.) Trev. is an endangered epiphytic fern ally with economical, traditional and horticultural interest. It posses various alkaloids like huperzine, huperzinine, lycoporine and carina-tumine which are responsible for its ...
Sanatombi Devi YUMKHAM, Potsangbam Kumar SINGH   +1 more
doaj   +3 more sources