Results 31 to 40 of about 12,358,109 (167)

Metabolomic and metagenomic analyses elucidate the role of intercropping in mitigating continuous cropping challenges in tobacco

Frontiers in Plant Science
IntroductionCrop rotation of tobacco with other crops could effectively break the negative impact of continuous tobacco cropping, but the mechanisms of intercropping system effects on tobacco, especially on the rhizosphere, are not clear.MethodsIn this ...
Ming Liu, Ming Liu, Rujun Xue, Shuangzhen Jin, Kaiyuan Gu, Jie Zhao, Shuyue Guan, Xiaoyu Xie, Jiaen Su, Longchang Wang   +9 more
doaj   +1 more source

Microtubules in Spinal Cord Injury: From Cytoskeletal Dysregulation to Therapeutic Regeneration

Journal of Neurochemistry, Volume 170, Issue 8, August 2026.
Graphical illustration of the microtubule interactome following spinal cord injury as potential targets for therapy. ABSTRACT Spinal cord injury (SCI) triggers an immediate and sustained disruption of the composition and organization of the neuronal cytoskeleton.
Itzhak Fischer, Peter W. Baas
wiley   +1 more source

Integrated Transcriptomic Profiling Reveals Candidate Genes for Huperzine A Biosynthesis in Huperzia serrata

Horticulturae
Huperzine A (HupA) is a natural Lycopodium alkaloid known for its potent neuroprotective properties through the inhibition of acetylcholinesterase. Nevertheless, the limited understanding of its biosynthesis restricts its broader application.
Ming Lei, Jing Wang, Cui Li, Han Liu, Xiao-Mei Liu, Hong Liu, Wei Ye, Zhao-Di Wen, Ying Hu, Shi-Xin Feng, Xia-Lian Ou, Zhan-Jiang Zhang   +11 more
doaj   +1 more source

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

Food Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du, Yifan Zhao, Li Dong, Chen Ma, Xiaosong Hu, Daotong Li, Fang Chen, Yinghua Luo   +7 more
wiley   +1 more source

The Role of Nootropic Supplements in Sports: Enhancing Cognitive and Physical Performance Simultaneously

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
The review examines the nootropic effects of substances used in sports through their impact on neurotransmission, neuroendocrine control, energy production, synaptic plasticity, and neurovascular connections. The four key neurotransmitters dopamine, acetylcholine, serotonin, and GABA function to control motivation, attention, fatigue perception, and ...
Zheng Yi
wiley   +1 more source

Exploring Linalool‐Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition

Phytotherapy Research, Volume 40, Issue 5, Page 2604-2631, May 2026.
Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli, Giovanni Roviello, Giorgia Magliocca, Emilia Esposito, Anna Pannaccione   +4 more
wiley   +1 more source

Development of a Sensitive High-Performance Liquid Chromatographic Method with Simple Extraction for Simultaneous Determination of Huperzine A and Huperzine B in the Species Containing Lycopodium Alkaloids

Journal of AOAC INTERNATIONAL, 2009
Abstract A sensitive HPLC method with simple extraction was developed for simultaneous determination of huperzine A (HupA) and huperzine B (HupB) in Huperzia serrata, H. crispata, H. miyoshiana, and Lycopodiastrum casuarinoides. In order to avoid conventional multiple-step and time-consuming sample preparation methods, direct reflux ...
Yanqing, Zhang, Junbo, Xie, Wen-Qian, Chen, Tian-Yan, Zhou, Wei, Lu   +4 more
openaire   +2 more sources

Recent Advances in Carbonyl–Olefin and Carbonyl–Alkyne Metathesis Reactions

ChemistryEurope, Volume 4, Issue 4, April 2026.
Carbonyl–olefin and carbonyl–alkyne metathesis enable atom‐economic C–C bond formation beyond classical olefin metathesis. This review highlights recent advances in photochemical, Lewis‐acid, Brønsted‐acid, and organocatalytic strategies, mechanistic insights, and synthetic applications, showcasing carbonyl metathesis as a versatile platform for modern
Komal Kalonia, Ramees Komath, Martin Breugst   +2 more
wiley   +1 more source

Huperzine A protects C6 rat glioma cells against oxygen–glucose deprivation-induced injury [PDF]

, 2007
The protective effects of huperzine A against oxygen–glucose deprivation (OGD)-induced injury in C6 cells were investigated. OGD for 6h and reoxygenation for 6h enhanced phosphorylation and degradation of IκBα and nuclear translocation of nuclear factor ...
Tang, Xi Can, Wang, Zhi Fei
core   +1 more source

Alzheimer's disease drug development pipeline: 2026

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.
Abstract INTRODUCTION Discovery and development of new therapies for Alzheimer's disease (AD) are urgently needed to address the world's growing population of individuals on the AD pathophysiological continuum. Clinicaltrials.gov is a resource for studying drugs in development for treatment of AD. RESULTS There are currently 158 drugs in 192 AD trials.
Jeffrey L. Cummings, Yadi Zhou, Yuxin Yang, Kate Zhong, Jorge Fonseca, Amanda Leisgang Osse, Feixiong Cheng   +6 more
wiley   +1 more source