Results 141 to 150 of about 2,786 (199)

Phytochemical based on nanoparticles for neurodegenerative alzheimer disease management: Update review. [PDF]

Discov Nano
Youssef B, Ibrahim EA, Moselhy SS, ElShebiney S, Elabd WK.   +4 more
europepmc   +1 more source

Exploring the molecular mechanisms of huperzine a in the treatment of rosacea through network pharmacology, machine learning, and molecular dynamics simulations. [PDF]

Front Pharmacol
Luo X, Yang S, Zhong L, Zhang P.
europepmc   +1 more source

Drug-Induced Liver Injury with Novel Fat Burner AlbutarexV2 in an Active Duty Sailor. [PDF]

Mil Med
Lilley LJ, Wiseman M, Sadowski B.
europepmc   +1 more source

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Divergent Total Synthesis of the Lycopodium Alkaloids Huperzine A, Huperzine B, and Huperzine U

The Journal of Organic Chemistry, 2013
Huperzine A, huperzine B, and huperzine U are congeners isolated from the Chinese herb Huperzia serrata (= Lycopodium serratum ) in minuscule amounts. The most efficient total synthesis of huperzine A, the first asymmetric total syntheses of huperzine B, and the first total synthesis of huperzine U have been achieved efficiently in overall yields of 17%
Rui, Ding, Jian-Guo, Fu, Guang-Qiang, Xu, Bing-Feng, Sun, Guo-Qiang, Lin   +4 more
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Huperzine A for Alzheimer's disease

Cochrane Database of Systematic Reviews, 2006
Alzheimer's disease (AD) has become a major public health problem around the world due to its increasing prevalence, long duration, caregiver burden, and high financial cost of care. The degeneration of acetylcholine-containing neurons in the basal forebrain has been implicated in the symptoms of AD.
J, Li, H M, Wu, R L, Zhou, G J, Liu, B R, Dong   +4 more
openaire   +3 more sources

Microbial transformation of (−)-Huperzine A

Tetrahedron Letters, 2010
Five products were yielded from the transformation of (−)-Huperzine A (1) by Streptomyces griseus CACC 200300. Their structures were determined as 16-hydroxyl huperzine A (2), 14α-hydroxyl huperzine A (3), huperzine A 8α,15α-epoxide (4), 13N-formyl huperzine A (5), and 13N-acetyl huperzine A (6) on the basis of their chemical and physical data.
Jungui Dai, Xinyuan Zhang
exaly   +2 more sources

Mechanism of inhibition of cholinesterases by huperzine A

Biochemical and Biophysical Research Communications, 1992
Huperzine A, an alkaloid isolated from Huperzia serrata was found to reversibly inhibit acetylcholinesterases (EC 3.1.1.7) and butyrylcholinesterases (EC 3.1.1.8) with on- and off-rates that depend on both the type and the source of enzyme. Long-term incubation of high concentrations of purified cholinesterases (1-8 microM) with huperzine A did not ...
Y, Ashani, J O, Peggins, B P, Doctor
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Synthesis of a hybrid analog of the acetylcholinesterase inhibitors huperzine A and huperzine B

Tetrahedron Letters, 2001
Abstract The synthesis of a new hybrid analog of the acetylcholinesterase (AChE) inhibitors huperzine A and B is reported. An intramolecular reductive dicarbonyl coupling was used as a key reaction for constructing the tetracyclic ring system.
V Rajendran, Suo-Bao Rong, Ashima Saxena, Bhupendra P Doctor, Alan P Kozikowski   +4 more
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A Convergent Approach to Huperzine A and Analogues.

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Seán A, Kelly, Yann, Foricher, John, Mann, Jonathan M, Bentley   +3 more
openaire   +2 more sources