Results 51 to 60 of about 253,811 (265)

Injectable Dual‐Network Hydrogel System for Osteochondral Repair Combining Immunomodulation, Mechanical Adaptability, and Enhanced Tissue Integration

Advanced Functional Materials, EarlyView.
A UV‐triggered injectable dual‐network hydrogel is reported as the first application of bletilla striata polysaccharide (BSP) in osteochondral repair. By integrating methacrylamide‐modified BSP and nitrobenzaldehyde‐functionalized hyaluronic acid, the system achieves immunomodulation, mechanical reinforcement, and dynamic tissue adhesion, thereby ...
Jiaming Cui, Feifei Zhou, Yuan Luo, Tao Ouyang, Huiwu Zhang, Songmiao Cheng, Qiang Li, Xu Jiang, Yingying Yu, Yicheng Wang, Hong Ming   +10 more
wiley   +1 more source

The structure, physiology, and biomechanics of articular cartilage: injury and repair

Acta Orthopaedica et Traumatologica Turcica, 2020
Hyaline cartilage which surrounds the articular surfaces and allows for painless movement of synovial joints by reducing friction is composed of chondrocytes embedded within an extracellular matrix made up of a macromolecular framework and water.
Hasan TATARİ
doaj  

Sprifermin (rhFGF18) enables proliferation of chondrocytes producing a hyaline cartilage matrix.

Osteoarthritis and Cartilage, 2017
OBJECTIVE Fibroblast growth factor (FGF) 18 has been shown to increase cartilage volume when injected intra-articularly in animal models of osteoarthritis (OA) and in patients with knee OA (during clinical development of the recombinant human FGF18 ...
A. Gigout, H. Guehring, D. Froemel, A. Meurer, H. LadelChristoph, D. Reker, A. Bay-Jensen, M. Karsdal, S. Lindemann   +8 more
semanticscholar   +1 more source

Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction

Advanced Functional Materials, EarlyView.
Despite over three decades of research, no tissue‐engineered solution for auricular reconstruction in microtia patients has reached clinical translation. The key challenge lies in generating functional elastic cartilage ex vivo. Here, we integrate synergistic cell‐biomaterial strategies to engineer auricular grafts with mechanical and histological ...
Philipp Fisch, Sandra Kessler, Simone Ponta, Anna Puiggalí‐Jou, Guoliang Lyu, Killian Flégeau, Anastasiya Martyts, Florian Roth, David Fercher, Filippo M. Rijli, Daniel Simmen, Eva Novoa Olivares, Thomas Linder, Marcy Zenobi‐Wong   +13 more
wiley   +1 more source

Cell Therapy and Tissue Engineering Products for Chondral Knee Injuries

Revista Colombiana de Biotecnología, 2017
The articular cartilage is prone to suffer lesions of different etiology, being the articular cartilage lesions of the knee the most common. Although most conventional treatments reduce symptoms they lead to the production of fibrocartilage, which has ...
Adriana Flórez Cabrera, Martha Isabel González Duque, Marta Raquel Fontanlla   +2 more
doaj   +1 more source

3D bioprinting modified autologous matrix-induced chondrogenesis(AMIC) technique for repair of cartilage defects

Materials & Design, 2021
Three-dimensional (3D) printing technology, has achieved good results in articular cartilage damage repair, yet regeneration of hyaline cartilage similar to native cartilage and effectively performing clinical transformation remain challenging.
Yang Zhou, Ran Qin, Tong Chen, Kaibin Zhang, Jianchao Gui   +4 more
doaj   +1 more source

In Situ 3D Bioprinting: Impact of Cross‐Linking on the Adhesive Properties of Hydrogels

Advanced Functional Materials, EarlyView.
In situ 3D bioprinting enables the direct deposition of cell‐laden, adhesive biomaterials for on‐site tissue regeneration. This review provides a comprehensive overview of how cross‐linking influences the bioadhesive properties of hydrogels used in 3D bioprinting, highlighting cross‐linking triggers, bioadhesion mechanisms, polymer interpenetration ...
Odile Romero Fernandez, Mulazim Hussain Asim, Shumaila Arshad, Gergely Kali, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury

Nature Communications, 2022
The growth plate cartilage supports long bone growth. Here the authors identify FoxA2+ long term stem cells in the growth plate that are stratified with short term PTHrP+ cells, participate in production of hyaline cartilage, expand in response to trauma,
Shanmugam Muruganandan, Rachel Pierce, Dian Astari Teguh, Rocio Fuente Perez, Nicole Bell, Brandon Nguyen, Katherine Hohl, Brian D. Snyder, Mark W. Grinstaff, Hannah Alberico, Dori Woods, Yiwei Kong, Corneliu Sima, Sanket Bhagat, Kailing Ho, Vicki Rosen, Laura Gamer, Andreia M. Ionescu   +17 more
doaj   +1 more source

Hybrid bioprinting of chondrogenically induced human mesenchymal stem cell spheroids [PDF]

, 2020
To date, the treatment of articular cartilage lesions remains challenging. A promising strategy for the development of new regenerative therapies is hybrid bioprinting, combining the principles of developmental biology, biomaterial science, and 3D ...
Asadian, Mahtab, De Geyter, Nathalie, De Moor, Lise, Declercq, Heidi, Dubruel, Peter, Fernandez, Sélina, Tytgat, Liesbeth, Van Vlierberghe, Sandra, Vercruysse, Chris   +8 more
core   +2 more sources

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source