Results 271 to 280 of about 58,192 (295)

Hyaluronan: an overview.

Journal of biological regulators and homeostatic agents, 2017
Hyaluronic acid (HA) is a polyanionic natural polymer occurring as a linear polysaccharide composed of glucuronic acid and N-acetylglucosamine repeats. Hyaluronic acid has a wide range of applications with its excellent physicochemical properties such as biodegradability, biocompatibility, non-toxicity, non-immunogenicity and serves as an excellent ...
Abbruzzese F, Basoli F, Costantini M, Giannitelli SM, Gori M, Mozetic P, Rainer A, Trombetta M   +7 more
openaire   +2 more sources

Hyaluronan and Hyaluronan Synthases: Potential Therapeutic Targets in Cancer

Current Drug Target -Cardiovascular & Hematological Disorders, 2005
Current models of oncogenesis describe cancer as a progression of genetic mutations in a tumor cell mass. However, tumors are more than a clonal expansion of malignant cells. Tumors are heterogeneous, with a complex 3D structure, analogous to organs comprised of different tissues.
Linda M. Pilarski, Sophia Adamia, Christopher A. Maxwell   +2 more
openaire   +3 more sources

Therapeutic applications of hyaluronan

Mol. BioSyst., 2010
Hyaluronan (HA), a multifunctional, high molecular weight glycosaminoglycan, is a component of the majority of extracellular matrices. HA is synthesised in a unique manner by a family of hyaluronan synthases, degraded by hyaluronidases and exerts a biological effect by binding to families of cellular receptors, the hyaladhedrins.
Gaffney, John, Matou-Nasri, Sabine, Grau-Olivares, Marta, Slevin, Mark   +3 more
openaire   +3 more sources

Evaluation of the physical and biological properties of hyaluronan and hyaluronan fragments

International Journal of Pharmaceutics, 2011
Hyaluronan (HA) has been extensively used for various medical applications, including osteoarthritis, tissue augmentation and ocular surgery. More recently, it has been investigated for use in polymer therapeutics as a carrier for drugs and biologically active proteins, thanks to its biodegradability, biocompatibility and inherent biological properties.
Elaine Lesley Ferguson, Peter C. Griffiths, Jessica L Roberts, David Thomas, Ryan Moseley   +4 more
openaire   +3 more sources

Hyaluronan and the “Mushroom” Technique: An Assessment of Hyaluronan Injections into the Glans

Dermatologic Surgery, 2011
An Asian technique of injecting collagen below the corona of the glans-the "mushroom" technique-increases the diameter of the penis glans and heightens sexual sensations for the participant and his sexual partner.To improve the physical and aesthetic results of the "mushroom" technique-compared with previous procedures using collagen-by using a new ...
Patrick Micheels, Badwi Elias, Eric Pujos, Stéphane Saint Hillier   +3 more
openaire   +3 more sources

Importance of Hyaluronan Length in a Hyaladherin-Based Assay for Hyaluronan

Analytical Biochemistry, 2002
Specific hyaladherin-based assays have been set up to measure the concentration of hyaluronan in biological fluids. Hyaluronectin (HN; a hyaladherin extracted from ovine brain) binds to hyaluronan (HA) that must be 10 units (HA10) or more long. It was therefore of interest to determine whether HN would continue to bind to HA10 in full-length HA since ...
Frédéric Tranchepain, Philippe Bertrand, Jean-Claude Vincent, Brigitte Deschrevel, Catherine Maingonnat, Marie-Noëlle Courel, Bertrand Delpech   +6 more
openaire   +3 more sources

Depolymerization of hyaluronan by sonication

Glycoconjugate Journal, 1993
High molecular weight hyaluronan (M(r) 400,000) obtained from human umbilical cord was depolymerized by sonication for 10 h into small molecules and finally into molecules of constant size (M(r) 11,000). The molecular size of the depolymerized hyaluronan was unaltered even under different conditions of sonication.
Toshiya Nakamura, Masahiko Endo, Yoshida Yutaka, Kohmei Kubo, Keiichi Takagaki   +4 more
openaire   +3 more sources

Revisiting the hallmarks of cancer: the role of hyaluronan.

Seminars in Cancer Biology, 2020
Ilaria Caon, B. Bartolini, Arianna Parnigoni, E. Caravà, P. Moretto, M. Viola, E. Karousou, D. Vigetti, A. Passi   +8 more
semanticscholar   +1 more source

Hyaluronan: from extracellular glue to pericellular cue

Nature Reviews. Cancer, 2004
B. Toole
semanticscholar   +1 more source

Hyaluronan

2017
A. M. Gressner, O. A. Gressner
openaire   +1 more source