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Hyaluronic Acid Basics and Rheology

Clinics in Plastic Surgery, 2022
Hyaluronic acid (HA) is the most common dermal filler in use. It improves wrinkles and volume loss not only by filling and volumizing but also by hydrating the injected area with its water affinity. It is a naturally occurring component of skin, and there is a negligible risk of immunologic or allergic reaction with injection. It is rapidly degraded by
Grace T, Wu, Joanna, Kam, Jason D, Bloom
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The Biosynthesis of Hyaluronic Acid

1957
Publisher Summary The hyaluronic acid is the only heteroglycan whose biosynthesis has been examined in detail. Because aminodeoxy sugar units are present, the polysaccharide is an aminodeoxypolysaccharide or, as it is more commonly termed, a “mucopolysaccharide.” Hyaluronic acid is a copolymer of two sugar units, which alternate in a linear chain ...
Roy L. Whistler, E.J. Olson
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Biotinylated Hyaluronic Acid as a Probe for Identifying Hyaluronic Acid-Binding Proteins

Analytical Biochemistry, 1995
The glycosaminoglycans hyaluronan (HA), heparin, and chondroitin sulfate were biotinylated using biotin-x-hydrazide (biotin-epsilon-aminocaproyl hydrozyde) in conjunction with N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride, an activating agent for carboxyl groups.
Baihua Yang, Paul F. Goetinck, Bo Yang
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Hyaluronic Acid for Hands [PDF]

open access: possible, 2020
Context: Lack of volume in the back of the hands, evidencing bones, vessels, and tendons, is a very common complaint concerning this area. During the last decade, there have been significant advances in the technology embedded in hyaluronic acid (HA) products, as well as a refinement of application techniques that, together, permitted the HA to become ...
Ricardo Limongi Fernandes   +1 more
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Hyaluronic acid and hyaluronic acid-binding proteins in brain extracellular matrix

Anatomy and Embryology, 1993
Hyaluronic acid (HA) plays the main structural role in the formation of brain extracellular matrix (ECM). The extracellular space appears empty by electron microscopy because HA is readily dissolved during the preparation of tissues for ultrastructural studies.
Amico Bignami   +3 more
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Hyaluronic acid supplementation

Current Rheumatology Reports, 2000
As evidenced by publication of a new set of guidelines for the treatment of osteoarthritis (OA) by the American College of Rheumatology after only 5 years, modalities available for the management of OA have undergone significant changes. New therapeutic approaches include the use of cyclo-oxygenase-2 inhibitors, and intra-articular hyaluronans (HA). HA,
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Hyaluronic Acid

Journal of Voice, 2002
The extracellular matrix (ECM), once regarded simply as a structural scaffold, is now recognized as an important modulator of cellular behavior and function. One component that plays a prominent role in this process is hyaluronic acid (HA)--a molecule found in many different tissues.
Steven D. Gray   +2 more
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Hyaluronic Acid

2011
Hyaluronic acid (HA) is an unsulfated glycosaminoglycan that is a ubiquitious component of the extracellular matrix. This chapter first introduces the chemical structure, biophysical properties, and the biological context of HA. Next, the production of HA from vertebrate, bacterial sources, and chemoenzymatic sources is described, along with relevant ...
J.-W. Kuo, G.D. Prestwich
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Recombinant Production of Hyaluronic Acid

Current Pharmaceutical Biotechnology, 2008
Presently, the two main commercial sources of hyaluronic acid (HA) are rooster combs and streptococci. Harvesting from rooster combs is complex and costly. Streptococci are difficult to genetically manipulate and require complex media for growth. Both sources have potential problems with unwanted by-products, such as allergens and toxins.
Philip E. Pummill, Stephen Brown
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Complications of Hyaluronic Acid Fillers

Facial Plastic Surgery, 2009
Hyaluronic acid filler use, user groups, and indications have expanded significantly in the past several years. This group of fillers is extremely safe in experienced hands. Complications are infrequent but can be devastating. There can be no substitution for recognized and specific training.
Nowell Solish, Michael Weinberg
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