Results 21 to 30 of about 5,538 (152)

Effect of hyaluronic acid: Mechanistic investigations via topological and functional analysis of its protein interaction network [PDF]

, 2021
Purpose: To predict molecular targets and the mechanism of action of hyaluronic acid against various disease conditions. Methods: The present study was designed and conducted based on the principle of network pharmacology, protein-protein interaction ...
Dan, Luo, Ting, Yu Li, Xi, Ji, Xue, Li
core   +2 more sources

A new scenario of bioprospecting of Hymenoptera venoms through proteomic approach

Journal of Venomous Animals and Toxins including Tropical Diseases, 2011
Venoms represent a huge and essentially unexplored reservoir of bioactive components that may cure diseases that do not respond to currently available therapies.
LD Santos, M Pieroni, ARS Menegasso, JRAS Pinto, MS Palma   +4 more
doaj   +1 more source

Co-occurrence based meta-analysis of scientific texts: retrieving biological relationships between genes [PDF]

, 2005
MOTIVATION: The advent of high-throughput experiments in molecular biology creates a need for methods to efficiently extract and use information for large numbers of genes.
Dorssers, L.C.J. (Lambert), Eijk, C.C. (Christiaan) van der, Jelier, R. (Rob), Jenster, G.W. (Guido), Kors, J.A. (Jan), Mons, B. (Barend), Mulligen, E.M. (Erik) van   +6 more
core   +3 more sources

Alterations in innate immunity and epithelial cell differentiation are the molecular pillars of hidradenitis suppurativa

Journal of the European Academy of Dermatology and Venereology, Volume 34, Issue 4, Page 846-861, April 2020., 2020
Abstract Background The large unmet need of hidradenitis suppurativa/acne inversa (HS) therapy requires the elucidation of disease‐driving mechanisms and tissue targeting. Objective Robust characterization of the underlying HS mechanisms and detection of the involved skin compartments.
C.C. Zouboulis, A. Nogueira da Costa, E. Makrantonaki, X.X. Hou, D. Almansouri, J.T. Dudley, H. Edwards, B. Readhead, O. Balthasar, G.B.E. Jemec, N.G. Bonitsis, G. Nikolakis, D. Trebing, K.C. Zouboulis, A.M. Hossini   +14 more
wiley   +1 more source

Trophoblast-induced changes in C-x-C motif chemokine 10 expression contribute to vascular smooth muscle cell dedifferentiation during spiral artery remodeling. [PDF]

, 2013
Objective- During pregnancy, fetal trophoblast disrupt endothelial cell and vascular smooth muscle cell (VSMC) interactions in spiral arteries of the maternal decidua to enable increased nutritional and oxygen delivery to the fetus.
Begum, R, Cartwright, JE, Laing, K, Thilaganathan, B, Wallace, AE, Whitley, GS   +5 more
core   +1 more source

Cynanchum paniculatum and Its Major Active Constituents for Inflammatory‐Related Diseases: A Review of Traditional Use, Multiple Pathway Modulations, and Clinical Applications

Evidence-Based Complementary and Alternative Medicine, Volume 2020, Issue 1, 2020., 2020
Cynanchum paniculatum Radix, known as Xuchangqing in Chinese, is commonly prescribed in Chinese Medicine (CM) for the treatment of various inflammatory diseases. The anti‐inflammatory property of Cynanchum paniculatum can be traced from its wind‐damp removing, collaterals’ obstruction relieving, and toxins counteracting effects as folk medicine in CM ...
Jing-xian Chen, Chien-shan Cheng, Jie Chen, Ling-ling Lv, Zi-jie Chen, Chuan Chen, Lan Zheng, Yuan Xu   +7 more
wiley   +1 more source

Maternal exposure to a Western-style diet causes differences in intestinal microbiota composition and gene expression of suckling mouse pups [PDF]

, 2016
Scope:The long-lasting consequences of nutritional programming during the early phase of life have become increasingly evident. The effects of maternal nutrition on the developing intestine are still underexplored.
Alfaradhi, Barker, Belzer, Bolton, Boulesteix, Cao, Cao, Caporaso, Cole, Cox, Dai, Daniel, David, Derrien, Desai, Desmarchelier, Everard, Fernandes, Filippo, Ganu, Gonzalez, Hanson, Hashimoto, Hildebrandt, Hjalt, Irizarry, Isolauri, Izcue, Joyce, Klezovitch, Koenig, Kucera, Ley, Lillycrop, Lin, Liu, Maier, Matsuo, Mischke, Muegge, Neville, Palmer, Ritchie, Saeed, Saeed, Sartor, Scholtens, Steegenga, Steegenga, Stenson, Tan, Tremblay, Walker, Walker, Wells, Williams, Wit, Wit, Wu, Yatsunenko, Zhang, Zhou   +61 more
core   +2 more sources

A Novel Hyaluronidase from Brown Spider (Loxosceles intermedia) Venom (Dietrich's Hyaluronidase): From Cloning to Functional Characterization [PDF]

, 2013
Loxoscelism is the designation given to clinical symptoms evoked by Loxosceles spider's bites. Clinical manifestations include skin necrosis with gravitational spreading and systemic disturbs. the venom contains several enzymatic toxins.
Chaim, Olga Meiri, Ferrer, Valeria Pereira, Gremski, Luiza Helena, Gremski, Waldemiro, Mari, Thiago Lopes de, Nader, Helena Bonciani, Senff-Ribeiro, Andrea, Silva, Dilza Trevisan, Silveira, Rafael Bertoni da, Veiga, Silvio Sanches   +9 more
core   +4 more sources

Endothelin receptor-A mediates degradation of the glomerular endothelial surface layer via pathologic crosstalk between activated podocytes and glomerular endothelial cells.

Kidney International, 2019
Emerging evidence of crosstalk between glomerular cells in pathological settings provides opportunities for novel therapeutic discovery. Here we investigated underlying mechanisms of early events leading to filtration barrier defects of podocyte and ...
Kerstin Ebefors, R. Wiener, Liping Yu, E. Azeloglu, Z. Yi, F. Jia, Weijia Zhang, M. H. Baron, J. He, B. Haraldsson, Ilse S. Daehn   +10 more
semanticscholar   +1 more source

Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats [PDF]

, 2008
The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression in the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats.
Bell, Richard L., Carr, Lucinda G., Edenberg, Howard J., Kimpel, Mark W., Liang, Tiebing, McBride, William J., McClintick, Jeanette N., Rodd, Zachary A., Strother, Wendy N.   +8 more
core   +1 more source