Results 91 to 100 of about 3,781,598 (274)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Brassinosteroid and jasmonic acid pathways mediate the effect of high temperature on the outcrossing rate of photo-thermo-sensitive genic male-sterile rice lines

BMC Plant Biology
Background The development and widespread adoption of hybrid rice have significantly contributed to global food security. However, the relatively high cost of hybrid seeds remains a limiting factor for its broader application.
Duo Lan, Pengpeng Fang, Li Zhang, Jia Zeng, Wuhan Zhang, Qiang He, Xiaolin Li, Ying Lv, Huafeng Deng, Fu Shu, Pingyong Sun   +10 more
doaj   +1 more source

Neuroinflammation in GAD65 Antibody‐Associated Epilepsy Measured Using [18F]DPA‐714 PET/MRI

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The timing for initiating immunotherapy in patients with glutamic acid decarboxylase 65 (GAD65) antibody‐associated epilepsy is a challenge. We used the translocator protein radioligand [18F]DPA‐714 and PET to evaluate brain microglial activation.
Jingjing Chen, Yuying Zhang, Heyu Zhang, Jinming Zhang, Ningning Wang, Xintong Guo, Yicong Liu, Yue Liu, Xiangsong Zhang, Ziyi Chen, Guanzhong Ni   +10 more
wiley   +1 more source

Hybrid mesons [PDF]

Proceedings of Sixth International Conference on Quarks and Nuclear Physics — PoS(QNP2012), 2012
Proceedings of the Sixth International Conference on Quarks and Nuclear Physics (QNP2012).
openaire   +2 more sources

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

OsLAP6/OsPKS1, an orthologue of Arabidopsis PKSA/LAP6, is critical for proper pollen exine formation

Rice, 2017
Background Male fertility is crucial for rice yield, and the improvement of rice yield requires hybrid production that depends on male sterile lines.
Ting Zou, Qiao Xiao, Wenjie Li, Tao Luo, Guoqiang Yuan, Zhiyuan He, Mingxing Liu, Qiao Li, Peizhou Xu, Jun Zhu, Yueyang Liang, Qiming Deng, Shiquan Wang, Aiping Zheng, Lingxia Wang, Ping Li, Shuangcheng Li   +16 more
doaj   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

EdemaFlex: textile-based soft-robotic platform toward personalized hand edema therapy

npj Flexible Electronics
Hand edema hinders mobility and quality of life, yet prevailing solutions—manual lymphatic drainage or bulky pneumatic devices—are costly, clinic-bound, and rarely personalized.
Seonyoung Youn, Arhan Choudhury, Pin-Sung Ku, Wenyi Fu, Margaret Tsai, Mahika Rathod, Alyssa Pelak, Joan Stilling, Hsin-Liu (Cindy) Kao   +8 more
doaj   +1 more source

Identification of qAs1—A Minor-Effect QTL Controlling Grain Arsenic Accumulation in Rice Using Near-Isogenic Lines Under High-Arsenic and Flooded Conditions

Agronomy
Arsenic (As) contamination in rice poses a serious risk to food safety and human health. Genetic dissection of As-related quantitative trait loci (QTLs) provides a sustainable strategy for breeding low-As cultivars. In this study, we aimed to improve the
Liang Guo, Zheng Dong, Haibo Xiong, Xiaowu Pan, Wenqiang Liu, Zuwu Chen, Xiaoxiang Li   +6 more
doaj   +1 more source

Are Our Racial Concepts Necessarily Essentialist Due to Our Cognitive Nature? [PDF]

, 2019
Mallon and Kelly claim that hybrid constructionism predicts, at least, that (1) racial representations are stable over time and (2) that racial representations should vary more in mixed-race cultures than in cultures where ...
Bayruns Garcia, Eric
core