Results 61 to 70 of about 1,481,021 (274)

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

High efficiency polymer solar cells sensitized by red-emitting ZnCuInS nanoplatelets

Journal of Materials Research and Technology, 2022
We synthesized the two-dimensional Zn–Cu–In–S (ZCIS) semiconductor nanoplatelets and then modified their surface with 4-bromobenzenediazonium tetrafluoroborate. The surface modified ZCIS nanoplatelets were combined with the conventional photovoltaic hole
Guorong Sun, Wenfei Shen, Chenyu Zhu, Suo Zhao, Qiao Wang, Zhonglin Du, Yao Wang, Xianglong Hao, Mikhail Artemyev, Jianguo Tang   +9 more
doaj  

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

The Cds.71 on TMS5 May Act as a Mutation Hotspot to Originate a TGMS Trait in Indica Rice Cultivars

Frontiers in Plant Science, 2020
The gene tms5, which controls thermo-sensitive genic male sterility (TGMS), has been widely used in two-line hybrid rice breeding in China. The tms5 lines have two sources, namely, AnnongS-1 (AnS) and Zhu1S (ZhS) and, interestingly, are commonly subject ...
Yanning Tan, Yanning Tan, Xuewu Sun, Xuewu Sun, Baohua Fang, Xiabing Sheng, Zheli Li, Zhizhong Sun, Zhizhong Sun, Dong Yu, Dong Yu, Hai Liu, Hai Liu, Ling Liu, Meijuan Duan, Dingyang Yuan, Dingyang Yuan   +16 more
doaj   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

A category of hybrid systems [PDF]

arXiv, 2016
We propose a definition of the category of hybrid systems in which executions are special types of morphisms. Consequently morphisms of hybrid systems send executions to executions. We plan to use this result to define and study networks of hybrid systems.
arxiv  

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

SRAM and Mixed-Signal Logic With Noise Immunity in 3-nm Nano-Sheet Technology

IEEE Open Journal of the Solid-State Circuits Society
A modular 4.26 Mb SRAM based on a 82 Kb/block structure with mixed signal logic is fabricated, characterized, and demonstrated with full functionality in a 3-nm nanosheet (NS) technology.
Rajiv V. Joshi, J. Frougier, Alberto Cestero, Crystal Castellanos, Sudipto Chakraborty, Carl Radens, M. Silvestre, S. Lucarini, I. Ahsan, E. Leobandung   +9 more
doaj   +1 more source

Non-arithmetic hybrid lattices in $\mathrm{PU}(2,1)$ [PDF]

arXiv, 2019
We explore hybrid subgroups of certain non-arithmetic lattices in $\mathrm{PU}(2,1)$. We show that all of Mostow's lattices are virtually hybrids; moreover, we show that some of these non-arithmetic lattices are hybrids of two non-commensurable arithmetic lattices in $\mathrm{PU}(1,1)$.
arxiv