Results 71 to 80 of about 1,474,022 (242)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Hybrid atrial fibrillation ablation

In this state-of-the art review on hybrid atrial fibrillation (AF) ablation, we briefly focus on the pathophysiology of AF, the rationale for the hybrid approach, its technical aspects and the efficacy and safety outcomes after hybrid AF ablation, both ...
Bidar, Elham, van Cruchten, Cas, Luermans, Justin G. L. M., Maesen, Bart, Kawczynski, Michal, Heuts, Samuel, van der Heijden, Claudia A. J., Aerts, Luca, Chaldoupi, Sevasti-Marisevi   +8 more
core   +1 more source

Nanosecond ablation of alumina with an ytterbium fibre-laser: experimental study, topography and damage evaluation [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Programa de Pós-Graduação em Ciência e Engenharia de Materiais, Florianópolis, 2014.Abstract : The use of advanced ceramics has been limited by the high machining costs, with grinding and ...
Gomes, Diego Ribas
core  

Left Atrial Appendage Management with the Watchman Device during Hybrid Ablation of Atrial Fibrillation

Journal of Interventional Cardiology, 2019
Background. In the recent ESC/EACTS guidelines, left atrial appendage (LAA) occlusion or exclusion in patients undergoing (thoracoscopic) atrial fibrillation (AF) ablation surgery is recommended. The Watchman device (WD, Boston Scientific, Minnesota) has
Mindy Vroomen, Bart Maesen, Justin G. Luermans, Harry J. Crijns, Jos G. Maessen, Mark La Meir, Laurent Pison   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Debris cover and surface melt at a temperate maritime alpine glacier: Franz Josef Glacier, New Zealand [PDF]

, 2012
Melt rates on glaciers are strongly influenced by the presence of supraglacial debris, which can either enhance or reduce ablation relative to bare ice.
Brook, Martin S., Winkler, S, Hagg, W, Hagg, Wilfried, Winkler, Stefan, Brook, M. S.   +5 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Numerical Investigation of Nozzle Thermochemical Behaviour in Hybrid Rocket Motors [PDF]

, 2022
In this thesis work a physics-based model to predict nozzle thermochemical erosion is presented. This model is based on non-charring materials ablation phenomena and can be used to predict the erosion in the peculiar hybrid rocket motor environment and ...
Ruffin, Alessandro
core  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Including debris cover effects in a distributed model of glacier ablation [PDF]

, 2012
Distributed glacier melt models generally assume that the glacier surface consists of bare exposed ice and snow. In reality, many glaciers are wholly or partially covered in layers of debris that tend to suppress ablation rates.
Reid, Tim, Carenzo, Marco, Brock, Benjamin, Pellicciotti, Francesca   +3 more
core   +1 more source