Results 51 to 60 of about 454,881 (304)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effect of fiber stacking sequence and orientation on quasi- static indentation properties of sustainable hybrid carbon/ramie fiber epoxy composites

Current Research in Green and Sustainable Chemistry, 2022
Hybrid polymer composites reinforced with synthetic and natural fibers are gaining more interest in current composite technology in an effort to promote sustainability without sacrificing the performance of synthetic fiber reinforced polymer composites ...
Shukur Abu Hassan, J.S. Binoj, Kheng Lim Goh, B. Brailson Mansingh, K.C. Varaprasad, Mohd Yazid Yahya, Faten Ermala Che Othman, Usaid Ahmed, Didik Nurhadiyanto, Mujiyono, A.P. Wulandari   +10 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Stress Distribution Pattern in Class I Cavities Restored by Different Techniques According to the Stress Reducing Direct Composite Concept: A Finite Element Analysis

International Journal of Dentistry
Conclusion: In Class I cavities, application of polyethylene fiber beneath the micro-hybrid composite decreased the maximum stress applied to the adhesive and hybrid layers and total deformation, compared to the use of micro-hybrid composite alone ...
Seyedeh Maryam Tavangar, Reza Tayefeh Davalloo, Farideh Darabi, Gelareh Tajziehchi   +3 more
doaj   +1 more source

UD HYBRID COMPOSITE OVERLOAD SENSORS [PDF]

, 2017
Composite materials are widely used in various structural applications due to their low density, high specific strength and stiffness, corrosion resistance, and good fatigue properties. However composites usually fail in a catastrophic manner and detecting damage, if there is any, prior to final failure has been a significant challenge.
Rev, Tamas, Czél, Gergely, Jalalvand, Meisam, Wisnom, Michael R.   +3 more
openaire   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Mechanical and Acoustic properties of Bagasse – Coconut Coir based Hybrid Reinforced Composites

Journal of Natural Fibers, 2022
In this paper, a hybrid composite is developed from natural fibers of bagasse and coconut coir. The mechanical and acoustic properties of the hybrid composites are investigated.
M.K. Marichelvam, K. Kandakodeeswaran, M. Geetha   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Spectrometric analysis of intentionally stained hybrid and nanohybrid composites – An In vitro study

Journal of International Clinical Dental Research Organization, 2019
Background: This study aims to investigate the effects of different staining solutions on the color stability of hybrid composites and nanohybrid composites.
Babita Meena, Mukesh Hasija, K K Wadhwani, Deepti Wadhwa   +3 more
doaj   +1 more source